Serum heat shock protein 70 levels and lung cancer risk: A case-control study nested in a large cohort study

Koji Suzuki, Yoshinori Ito, Kenji Wakai, Miyuki Kawado, Shuji Hashimoto, Nao Seki, Masahiko Ando, Yoshikazu Nishino, Takaaki Kondo, Yoshiyuki Watanabe, Kotaro Ozasa, Takashi Inoue, Akiko Tamakoshi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Chronic inflammation contributes to the process of carcinogenesis, but few epidemiologic studies have examined associations with risk of lung cancer. Relationships between lung cancer risk and serum levels of both heat shock protein 70 (Hsp70) and high-sensitivity C-reactive protein (hsCRP) were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 240 deaths from lung cancer were identified through 1999, and 569 controls were matched for sex, age, and study area. Serum levels were measured in 189 cases and 377 controls for Hsp70 and in 209 cases and 425 controls for hsCRP. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, including smoking habits, were 0.83 (0.44-1.58), 1.41 (0.77-2.60), and 1.84 (0.92-3.71) for Hsp70 (Ptrend = 0.042) and 1.13 (0.67-1.91), 0.66 (0.38-1.16), and 1.19 (0.70-2.02) for hsCRP (P trend = 0.941). In males, odds ratios (95% confidence intervals) across quartiles were 1.30 (0.59-2.84), 1.74 (0.83-3.67), and 2.49 (1.06-5.85) for Hsp70 (Ptrend = 0.029). High levels of serum Hsp70 might thus be associated with increased risk of lung cancer among Japanese males, although further studies are needed to clarify associations between chronic inflammation and lung cancer.

Original languageEnglish
Pages (from-to)1733-1737
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number9
DOIs
Publication statusPublished - 09-2006

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

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