Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study

Fumio Sakauchi, Masanori Nojima, Mitsuru Mori, Kenji Wakai, Sadao Suzuki, Akiko Tamakoshi, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi & 16 others Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was planned in the late 1980s as a large-scale cohort study of persons in various areas of Japan. In the present study, we conducted a nested case-control study and examined associations of breast cancer risk with serum levels of insulin-like growth factors I and II (IGF-I, IGF-II), as well as insulin-like growth factor binding protein-3 (IGFBP-3), among women who participated in the JACC Study and donated their blood at the baseline. Sixty-three women who died or suffered from breast cancer were examined. Two or three controls were selected to match each case for age at recruitment and the study area. Controls were alive and not diagnosed as having breast cancer at the diagnosis date of the cases. Associations between the serum IGF-I, IGF-II, IGFBP-3 and breast cancer risk were evaluated using a conditional logistic regression model. In premenopausal Japanese women, IGF-I showed a marginal negative dose-dependent association with the breast cancer risk (trend P= 0.08), but any link disappeared on taking into account IGFBP-3 (trend P= 0.47), which was likely to be inversely associated with the risk. In postmenopausal women, IGFBP-3 showed a marginal dose-dependent association with the risk (trend P= 0.06). Further studies are needed to confirm these findings.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 01-12-2009
Externally publishedYes

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Breast Neoplasms
Serum
Japan
Cohort Studies
Logistic Models
Case-Control Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Sakauchi, F., Nojima, M., Mori, M., Wakai, K., Suzuki, S., Tamakoshi, A., ... Shio, H. (2009). Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study. Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 51-56.
Sakauchi, Fumio ; Nojima, Masanori ; Mori, Mitsuru ; Wakai, Kenji ; Suzuki, Sadao ; Tamakoshi, Akiko ; Ito, Yoshinori ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Nakachi, Kei ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Fujino, Yoshihisa ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 51-56.
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abstract = "The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was planned in the late 1980s as a large-scale cohort study of persons in various areas of Japan. In the present study, we conducted a nested case-control study and examined associations of breast cancer risk with serum levels of insulin-like growth factors I and II (IGF-I, IGF-II), as well as insulin-like growth factor binding protein-3 (IGFBP-3), among women who participated in the JACC Study and donated their blood at the baseline. Sixty-three women who died or suffered from breast cancer were examined. Two or three controls were selected to match each case for age at recruitment and the study area. Controls were alive and not diagnosed as having breast cancer at the diagnosis date of the cases. Associations between the serum IGF-I, IGF-II, IGFBP-3 and breast cancer risk were evaluated using a conditional logistic regression model. In premenopausal Japanese women, IGF-I showed a marginal negative dose-dependent association with the breast cancer risk (trend P= 0.08), but any link disappeared on taking into account IGFBP-3 (trend P= 0.47), which was likely to be inversely associated with the risk. In postmenopausal women, IGFBP-3 showed a marginal dose-dependent association with the risk (trend P= 0.06). Further studies are needed to confirm these findings.",
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Sakauchi, F, Nojima, M, Mori, M, Wakai, K, Suzuki, S, Tamakoshi, A, Ito, Y, Watanabe, Y, Inaba, Y, Tajima, K, Nakachi, K, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Tokudome, S, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 51-56.

Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study. / Sakauchi, Fumio; Nojima, Masanori; Mori, Mitsuru; Wakai, Kenji; Suzuki, Sadao; Tamakoshi, Akiko; Ito, Yoshinori; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Nakachi, Kei; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Fujino, Yoshihisa; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 01.12.2009, p. 51-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum Insulin-like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Risk of Breast Cancer in the JACC Study

AU - Sakauchi, Fumio

AU - Nojima, Masanori

AU - Mori, Mitsuru

AU - Wakai, Kenji

AU - Suzuki, Sadao

AU - Tamakoshi, Akiko

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/12/1

Y1 - 2009/12/1

N2 - The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was planned in the late 1980s as a large-scale cohort study of persons in various areas of Japan. In the present study, we conducted a nested case-control study and examined associations of breast cancer risk with serum levels of insulin-like growth factors I and II (IGF-I, IGF-II), as well as insulin-like growth factor binding protein-3 (IGFBP-3), among women who participated in the JACC Study and donated their blood at the baseline. Sixty-three women who died or suffered from breast cancer were examined. Two or three controls were selected to match each case for age at recruitment and the study area. Controls were alive and not diagnosed as having breast cancer at the diagnosis date of the cases. Associations between the serum IGF-I, IGF-II, IGFBP-3 and breast cancer risk were evaluated using a conditional logistic regression model. In premenopausal Japanese women, IGF-I showed a marginal negative dose-dependent association with the breast cancer risk (trend P= 0.08), but any link disappeared on taking into account IGFBP-3 (trend P= 0.47), which was likely to be inversely associated with the risk. In postmenopausal women, IGFBP-3 showed a marginal dose-dependent association with the risk (trend P= 0.06). Further studies are needed to confirm these findings.

AB - The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was planned in the late 1980s as a large-scale cohort study of persons in various areas of Japan. In the present study, we conducted a nested case-control study and examined associations of breast cancer risk with serum levels of insulin-like growth factors I and II (IGF-I, IGF-II), as well as insulin-like growth factor binding protein-3 (IGFBP-3), among women who participated in the JACC Study and donated their blood at the baseline. Sixty-three women who died or suffered from breast cancer were examined. Two or three controls were selected to match each case for age at recruitment and the study area. Controls were alive and not diagnosed as having breast cancer at the diagnosis date of the cases. Associations between the serum IGF-I, IGF-II, IGFBP-3 and breast cancer risk were evaluated using a conditional logistic regression model. In premenopausal Japanese women, IGF-I showed a marginal negative dose-dependent association with the breast cancer risk (trend P= 0.08), but any link disappeared on taking into account IGFBP-3 (trend P= 0.47), which was likely to be inversely associated with the risk. In postmenopausal women, IGFBP-3 showed a marginal dose-dependent association with the risk (trend P= 0.06). Further studies are needed to confirm these findings.

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