Serum levels of carotenoids in patients with osteonecrosis of the femoral head are lower than in healthy, community-living people

Toshiaki Okura, Taisuke Seki, Koji Suzuki, Naoki Ishiguro, Yukiharu Hasegawa

Research output: Contribution to journalArticle

Abstract

Purpose: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. Methods: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age-and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program. We measured and compared the serum levels of α-tocopherol (vitamin E) and total carotenoids, including zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, and β-carotene, in the ONFH and control groups using high-performance liquid chromatography. Results: The mean serum levels of total carotenoids were significantly lower in the ONFH group than in the control group (2.36 ± 1.26 and 3.79 ± 2.36 mmol/l, respectively, p < 0.001). However, no significant difference was found in a-tocopherol between the two groups (26.37 + 6.90 mmol/l in the ONFH group and 26.24 ± 6.28 mmol/l in the control group, p =0.920). Among each carotenoid, the serum levels of zeaxanthin/lutein, lycopene, and β-carotene were significantly lower in the ONFH group than in the control group (p < 0.001). Conclusions: The serum levels of carotenoids were lower in patients with ONFH than in healthy, community-living people. This result suggests that carotenoids may be related to the pathogenesis of ONFH.

Original languageEnglish
JournalJournal of Orthopaedic Surgery
Volume26
Issue number2
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Osteonecrosis
Carotenoids
Thigh
Serum
Control Groups
Lutein
Tocopherols
Antioxidants
Food
Vitamin E
Oxidative Stress
Age Groups
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

@article{b8d1df1b17804623ac62c27aef1b1510,
title = "Serum levels of carotenoids in patients with osteonecrosis of the femoral head are lower than in healthy, community-living people",
abstract = "Purpose: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. Methods: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age-and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program. We measured and compared the serum levels of α-tocopherol (vitamin E) and total carotenoids, including zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, and β-carotene, in the ONFH and control groups using high-performance liquid chromatography. Results: The mean serum levels of total carotenoids were significantly lower in the ONFH group than in the control group (2.36 ± 1.26 and 3.79 ± 2.36 mmol/l, respectively, p < 0.001). However, no significant difference was found in a-tocopherol between the two groups (26.37 + 6.90 mmol/l in the ONFH group and 26.24 ± 6.28 mmol/l in the control group, p =0.920). Among each carotenoid, the serum levels of zeaxanthin/lutein, lycopene, and β-carotene were significantly lower in the ONFH group than in the control group (p < 0.001). Conclusions: The serum levels of carotenoids were lower in patients with ONFH than in healthy, community-living people. This result suggests that carotenoids may be related to the pathogenesis of ONFH.",
author = "Toshiaki Okura and Taisuke Seki and Koji Suzuki and Naoki Ishiguro and Yukiharu Hasegawa",
year = "2018",
month = "1",
day = "1",
doi = "10.1177/2309499018770927",
language = "English",
volume = "26",
journal = "Journal of Orthopaedic Surgery",
issn = "1022-5536",
publisher = "Hong Kong Academy of Medicine Press",
number = "2",

}

Serum levels of carotenoids in patients with osteonecrosis of the femoral head are lower than in healthy, community-living people. / Okura, Toshiaki; Seki, Taisuke; Suzuki, Koji; Ishiguro, Naoki; Hasegawa, Yukiharu.

In: Journal of Orthopaedic Surgery, Vol. 26, No. 2, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum levels of carotenoids in patients with osteonecrosis of the femoral head are lower than in healthy, community-living people

AU - Okura, Toshiaki

AU - Seki, Taisuke

AU - Suzuki, Koji

AU - Ishiguro, Naoki

AU - Hasegawa, Yukiharu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. Methods: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age-and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program. We measured and compared the serum levels of α-tocopherol (vitamin E) and total carotenoids, including zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, and β-carotene, in the ONFH and control groups using high-performance liquid chromatography. Results: The mean serum levels of total carotenoids were significantly lower in the ONFH group than in the control group (2.36 ± 1.26 and 3.79 ± 2.36 mmol/l, respectively, p < 0.001). However, no significant difference was found in a-tocopherol between the two groups (26.37 + 6.90 mmol/l in the ONFH group and 26.24 ± 6.28 mmol/l in the control group, p =0.920). Among each carotenoid, the serum levels of zeaxanthin/lutein, lycopene, and β-carotene were significantly lower in the ONFH group than in the control group (p < 0.001). Conclusions: The serum levels of carotenoids were lower in patients with ONFH than in healthy, community-living people. This result suggests that carotenoids may be related to the pathogenesis of ONFH.

AB - Purpose: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. Methods: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age-and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program. We measured and compared the serum levels of α-tocopherol (vitamin E) and total carotenoids, including zeaxanthin/lutein, β-cryptoxanthin, lycopene, α-carotene, and β-carotene, in the ONFH and control groups using high-performance liquid chromatography. Results: The mean serum levels of total carotenoids were significantly lower in the ONFH group than in the control group (2.36 ± 1.26 and 3.79 ± 2.36 mmol/l, respectively, p < 0.001). However, no significant difference was found in a-tocopherol between the two groups (26.37 + 6.90 mmol/l in the ONFH group and 26.24 ± 6.28 mmol/l in the control group, p =0.920). Among each carotenoid, the serum levels of zeaxanthin/lutein, lycopene, and β-carotene were significantly lower in the ONFH group than in the control group (p < 0.001). Conclusions: The serum levels of carotenoids were lower in patients with ONFH than in healthy, community-living people. This result suggests that carotenoids may be related to the pathogenesis of ONFH.

UR - http://www.scopus.com/inward/record.url?scp=85053537980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053537980&partnerID=8YFLogxK

U2 - 10.1177/2309499018770927

DO - 10.1177/2309499018770927

M3 - Article

AN - SCOPUS:85053537980

VL - 26

JO - Journal of Orthopaedic Surgery

JF - Journal of Orthopaedic Surgery

SN - 1022-5536

IS - 2

ER -