Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor β-1, soluble Fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC study

Hiroshi Yatsuya, Hideaki Toyoshima, Koji Tamakoshi, Akiko Tamakoshi, Takaaki Kondo, Norihiko Hayakawa, Kiyomi Sakata, Shogo Kikuchi, Yoshiharu Hoshiyama, Yoshihisa Fujino, Tetsuya Mizoue, Noritaka Tokui, Takesumi Yoshimura, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka InabaHiroshi Suzuki, Hiroyuki Shimizu, Kenji Wakai, Shinkan Tokudome, Yoshinori Ito, Shuji Hashimoto, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Takayuki Nose, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

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10 Citations (Scopus)

Abstract

Background: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. Methods: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factor β-1 (TGF β 1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. Results: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P = 0.013 by two-way analysis of covariance controlling for matching variable). Conclusion: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

Original languageEnglish
Pages (from-to)S120-S125
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Yatsuya, H., Toyoshima, H., Tamakoshi, K., Tamakoshi, A., Kondo, T., Hayakawa, N., Sakata, K., Kikuchi, S., Hoshiyama, Y., Fujino, Y., Mizoue, T., Tokui, N., Yoshimura, T., Mori, M., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., ... Tajima, K. (2005). Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor β-1, soluble Fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC study. Journal of epidemiology, 15(SUPPL. 2), S120-S125. https://doi.org/10.2188/jea.15.S120