Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study

Masayo Kojima, Kenji Wakai, Shinkan Tokudome, Koji Suzuki, Koji Tamakoshi, Yoshiyuki Watanabe, Miyuki Kawado, Shuji Hashimoto, Norihiko Hayakawa, Kotaro Ozasa, Hideaki Toyoshima, Sadao Suzuki, Yoshinori Ito, Akiko Tamakoshi

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.

Original languageEnglish
Pages (from-to)462-471
Number of pages10
JournalAmerican Journal of Epidemiology
Volume161
Issue number5
DOIs
Publication statusPublished - 01-03-2005

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Unsaturated Fatty Acids
Colorectal Neoplasms
Prospective Studies
Odds Ratio
Confidence Intervals
Serum
Fatty Acids
alpha-Linolenic Acid
Docosahexaenoic Acids
Gas Chromatography
Case-Control Studies
Life Style
Japan
Cohort Studies
Logistic Models
Regression Analysis
Lipids
Weights and Measures
docosapentaenoic acid

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Kojima, Masayo ; Wakai, Kenji ; Tokudome, Shinkan ; Suzuki, Koji ; Tamakoshi, Koji ; Watanabe, Yoshiyuki ; Kawado, Miyuki ; Hashimoto, Shuji ; Hayakawa, Norihiko ; Ozasa, Kotaro ; Toyoshima, Hideaki ; Suzuki, Sadao ; Ito, Yoshinori ; Tamakoshi, Akiko. / Serum levels of polyunsaturated fatty acids and risk of colorectal cancer : A prospective study. In: American Journal of Epidemiology. 2005 ; Vol. 161, No. 5. pp. 462-471.
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Kojima, M, Wakai, K, Tokudome, S, Suzuki, K, Tamakoshi, K, Watanabe, Y, Kawado, M, Hashimoto, S, Hayakawa, N, Ozasa, K, Toyoshima, H, Suzuki, S, Ito, Y & Tamakoshi, A 2005, 'Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study', American Journal of Epidemiology, vol. 161, no. 5, pp. 462-471. https://doi.org/10.1093/aje/kwi066

Serum levels of polyunsaturated fatty acids and risk of colorectal cancer : A prospective study. / Kojima, Masayo; Wakai, Kenji; Tokudome, Shinkan; Suzuki, Koji; Tamakoshi, Koji; Watanabe, Yoshiyuki; Kawado, Miyuki; Hashimoto, Shuji; Hayakawa, Norihiko; Ozasa, Kotaro; Toyoshima, Hideaki; Suzuki, Sadao; Ito, Yoshinori; Tamakoshi, Akiko.

In: American Journal of Epidemiology, Vol. 161, No. 5, 01.03.2005, p. 462-471.

Research output: Contribution to journalArticle

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AU - Kojima, Masayo

AU - Wakai, Kenji

AU - Tokudome, Shinkan

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AU - Tamakoshi, Koji

AU - Watanabe, Yoshiyuki

AU - Kawado, Miyuki

AU - Hashimoto, Shuji

AU - Hayakawa, Norihiko

AU - Ozasa, Kotaro

AU - Toyoshima, Hideaki

AU - Suzuki, Sadao

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

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