TY - JOUR
T1 - Serum levels of polyunsaturated fatty acids and risk of colorectal cancer
T2 - A prospective study
AU - Kojima, Masayo
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Suzuki, Koji
AU - Tamakoshi, Koji
AU - Watanabe, Yoshiyuki
AU - Kawado, Miyuki
AU - Hashimoto, Shuji
AU - Hayakawa, Norihiko
AU - Ozasa, Kotaro
AU - Toyoshima, Hideaki
AU - Suzuki, Sadao
AU - Ito, Yoshinori
AU - Tamakoshi, Akiko
N1 - Funding Information:
Details of the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk (JACC Study), sponsored by Monbukagakusho (the Ministry of Education, Culture, Sports, Science and Technology of Japan), have been reported elsewhere (12, 13). The JACC Study involved 110,792 healthy residents who were aged 40–79 years at baseline and were recruited from 45 areas throughout Japan between 1988 and 1990. The subjects for the present study were restricted to 65,184 persons who lived in 24 study areas in which cancer registries were available. On enrollment, the participants completed a self-administered questionnaire that assessed demographic characteristics, lifestyle, and medical history. Blood samples were donated by 36.6 percent of the total study group (n = 23,863). Participants who reported a previous history of cancer (n = 409) were excluded from the analysis. Written informed consent for participation was obtained individually from most subjects, with the exception of those in study areas in which informed consent was provided at the group level after the aim of the study and the confidentiality of the data had been explained to community leaders. The study protocol was approved by the Ethics Committee of Medical Care and Research of the Fujita Health University School of Medicine, Japan.
Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (2; 14031222) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The JACC Study has also been supported by Grants-in-Aid for Scientific Research from the same ministry (61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, and 11181101).
PY - 2005/3/1
Y1 - 2005/3/1
N2 - To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
AB - To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
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U2 - 10.1093/aje/kwi066
DO - 10.1093/aje/kwi066
M3 - Article
C2 - 15718482
AN - SCOPUS:20044396173
VL - 161
SP - 462
EP - 471
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 5
ER -