Abstract
To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
| Original language | English |
|---|---|
| Pages (from-to) | 462-471 |
| Number of pages | 10 |
| Journal | American Journal of Epidemiology |
| Volume | 161 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-03-2005 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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Serum levels of polyunsaturated fatty acids and risk of colorectal cancer : A prospective study. / Kojima, Masayo; Wakai, Kenji; Tokudome, Shinkan; Suzuki, Koji; Tamakoshi, Koji; Watanabe, Yoshiyuki; Kawado, Miyuki; Hashimoto, Shuji; Hayakawa, Norihiko; Ozasa, Kotaro; Toyoshima, Hideaki; Suzuki, Sadao; Ito, Yoshinori; Tamakoshi, Akiko.
In: American Journal of Epidemiology, Vol. 161, No. 5, 01.03.2005, p. 462-471.Research output: Contribution to journal › Article
TY - JOUR
T1 - Serum levels of polyunsaturated fatty acids and risk of colorectal cancer
T2 - A prospective study
AU - Kojima, Masayo
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Suzuki, Koji
AU - Tamakoshi, Koji
AU - Watanabe, Yoshiyuki
AU - Kawado, Miyuki
AU - Hashimoto, Shuji
AU - Hayakawa, Norihiko
AU - Ozasa, Kotaro
AU - Toyoshima, Hideaki
AU - Suzuki, Sadao
AU - Ito, Yoshinori
AU - Tamakoshi, Akiko
PY - 2005/3/1
Y1 - 2005/3/1
N2 - To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
AB - To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
UR - http://www.scopus.com/inward/record.url?scp=20044396173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044396173&partnerID=8YFLogxK
U2 - 10.1093/aje/kwi066
DO - 10.1093/aje/kwi066
M3 - Article
C2 - 15718482
AN - SCOPUS:20044396173
VL - 161
SP - 462
EP - 471
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 5
ER -