Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death

Mamoru Kusaka, Yoko Kuroyanagi, Terumi Mori, Kayuri Nagaoka, Hitomi Sasaki, Takahiro Maruyama, Kunihiro Hayakawa, Ryoichi Shiroki, Hiroki Kurahashi, Kiyotaka Hoshinaga

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Because of a worldwide shortage of renal grafts, kidneys procured from donors after cardiac death (DCD) have recently become an important source of renal transplants. However, DCD kidneys often have complications with delayed graft function (DGF) and recipients require hemodialysis (HD) in the early period after kidney transplantation (KTx). This study evaluated serum NGAL as a potential specific parameter to predict early functional recovery of transplanted DCD kidneys. The average serum neutrophil gelatinase-associated lipocalin (NGAL) level in normal samples was 53 ± 30 ng/ml, while that in patients with chronic renal failure requiring HD was markedly raised at 963 ± 33 ng/ml. In patients undergoing a living-related KTx from a living donor (n = 11), serum NGAL level decreased rapidly after KTx, and only in two cases, with serum NGAL levels over 400 ng/ml on postoperative day 1 (POD1), was HD required due to DGF. In contrast, all patients undergoing a KTx from a DCD (n = 5) required HD due to DGF. Even in these cases, serum NGAL levels decreased rapidly several days after a KTx prior to the recovery of urine output and preceding the decrease in serum creatinine level. The pattern of decline in serum NGAL was biphasic, the decrease after the second peak indicating a functional recovery within the next several days. These data suggest that monitoring of serum NGAL levels may allow us to predict graft recovery and the need for HD after a KTx from a DCD.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalCell Transplantation
Volume17
Issue number1-2
DOIs
Publication statusPublished - 01-01-2008

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Transplantation (surgical)
Delayed Graft Function
Grafts
Kidney Transplantation
Tissue Donors
Recovery
Renal Dialysis
Serum
Kidney
Transplants
Lipocalin-2
Living Donors
Monitoring
Chronic Kidney Failure
Creatinine
Urine

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Kusaka, Mamoru ; Kuroyanagi, Yoko ; Mori, Terumi ; Nagaoka, Kayuri ; Sasaki, Hitomi ; Maruyama, Takahiro ; Hayakawa, Kunihiro ; Shiroki, Ryoichi ; Kurahashi, Hiroki ; Hoshinaga, Kiyotaka. / Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. In: Cell Transplantation. 2008 ; Vol. 17, No. 1-2. pp. 129-134.
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Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. / Kusaka, Mamoru; Kuroyanagi, Yoko; Mori, Terumi; Nagaoka, Kayuri; Sasaki, Hitomi; Maruyama, Takahiro; Hayakawa, Kunihiro; Shiroki, Ryoichi; Kurahashi, Hiroki; Hoshinaga, Kiyotaka.

In: Cell Transplantation, Vol. 17, No. 1-2, 01.01.2008, p. 129-134.

Research output: Contribution to journalArticle

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T1 - Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death

AU - Kusaka, Mamoru

AU - Kuroyanagi, Yoko

AU - Mori, Terumi

AU - Nagaoka, Kayuri

AU - Sasaki, Hitomi

AU - Maruyama, Takahiro

AU - Hayakawa, Kunihiro

AU - Shiroki, Ryoichi

AU - Kurahashi, Hiroki

AU - Hoshinaga, Kiyotaka

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