Serum oxidized low-density lipoprotein levels and risk of colorectal cancer

A case-control study nested in the Japan Collaborative Cohort Study

Koji Suzuki, Yoshinori Ito, Kenji Wakai, Miyuki Kawado, Shuji Hashimoto, Hideaki Toyoshima, Masayo Kojima, Shinkan Tokudome, Norihiko Hayakawa, Yoshiyuki Watanabe, Koji Tamakoshi, Sadao Suzuki, Kotaro Ozasa, Akiko Tamakoshi, M. Mori, Y. Motohashi, I. Tsuji, Y. Nakamura, H. Iso, H. Mikami & 26 others Y. Inaba, Y. Hoshiyama, H. Suzuki, H. Shimizu, S. Kikuchi, A. Koizumi, T. Kawamura, T. Miki, C. Date, K. Sakata, T. Nose, T. Yoshimura, K. Fukuda, N. Okamoto, H. Shio, Y. Ohno, T. Kitagawa, T. Kuroki, K. Tajima, T. Shimamoto, H. Tanaka, S. Hisamichi, M. Nakao, T. Suzuki, T. Hashimoto, T. Ishibashi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P trend = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P trend = 0.140). Further adjustment for serum total cholesterol and α-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P trend = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

Original languageEnglish
Pages (from-to)1781-1787
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number11
Publication statusPublished - 01-11-2004

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Case-Control Studies
Colorectal Neoplasms
Japan
Cohort Studies
Serum
Antibodies
Odds Ratio
oxidized low density lipoprotein
Confidence Intervals
Tocopherols
Colonic Neoplasms
Life Style
Epidemiologic Studies
Carcinogenesis
Oxidative Stress
Cholesterol

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Suzuki, Koji ; Ito, Yoshinori ; Wakai, Kenji ; Kawado, Miyuki ; Hashimoto, Shuji ; Toyoshima, Hideaki ; Kojima, Masayo ; Tokudome, Shinkan ; Hayakawa, Norihiko ; Watanabe, Yoshiyuki ; Tamakoshi, Koji ; Suzuki, Sadao ; Ozasa, Kotaro ; Tamakoshi, Akiko ; Mori, M. ; Motohashi, Y. ; Tsuji, I. ; Nakamura, Y. ; Iso, H. ; Mikami, H. ; Inaba, Y. ; Hoshiyama, Y. ; Suzuki, H. ; Shimizu, H. ; Kikuchi, S. ; Koizumi, A. ; Kawamura, T. ; Miki, T. ; Date, C. ; Sakata, K. ; Nose, T. ; Yoshimura, T. ; Fukuda, K. ; Okamoto, N. ; Shio, H. ; Ohno, Y. ; Kitagawa, T. ; Kuroki, T. ; Tajima, K. ; Shimamoto, T. ; Tanaka, H. ; Hisamichi, S. ; Nakao, M. ; Suzuki, T. ; Hashimoto, T. ; Ishibashi, T. / Serum oxidized low-density lipoprotein levels and risk of colorectal cancer : A case-control study nested in the Japan Collaborative Cohort Study. In: Cancer Epidemiology Biomarkers and Prevention. 2004 ; Vol. 13, No. 11. pp. 1781-1787.
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title = "Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: A case-control study nested in the Japan Collaborative Cohort Study",
abstract = "Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95{\%} confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P trend = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P trend = 0.140). Further adjustment for serum total cholesterol and α-tocopherol did not materially change these associations. Odds ratio (95{\%} confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P trend = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.",
author = "Koji Suzuki and Yoshinori Ito and Kenji Wakai and Miyuki Kawado and Shuji Hashimoto and Hideaki Toyoshima and Masayo Kojima and Shinkan Tokudome and Norihiko Hayakawa and Yoshiyuki Watanabe and Koji Tamakoshi and Sadao Suzuki and Kotaro Ozasa and Akiko Tamakoshi and M. Mori and Y. Motohashi and I. Tsuji and Y. Nakamura and H. Iso and H. Mikami and Y. Inaba and Y. Hoshiyama and H. Suzuki and H. Shimizu and S. Kikuchi and A. Koizumi and T. Kawamura and T. Miki and C. Date and K. Sakata and T. Nose and T. Yoshimura and K. Fukuda and N. Okamoto and H. Shio and Y. Ohno and T. Kitagawa and T. Kuroki and K. Tajima and T. Shimamoto and H. Tanaka and S. Hisamichi and M. Nakao and T. Suzuki and T. Hashimoto and T. Ishibashi",
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Suzuki, K, Ito, Y, Wakai, K, Kawado, M, Hashimoto, S, Toyoshima, H, Kojima, M, Tokudome, S, Hayakawa, N, Watanabe, Y, Tamakoshi, K, Suzuki, S, Ozasa, K, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Yoshimura, T, Fukuda, K, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Nakao, M, Suzuki, T, Hashimoto, T & Ishibashi, T 2004, 'Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: A case-control study nested in the Japan Collaborative Cohort Study', Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 11, pp. 1781-1787.

Serum oxidized low-density lipoprotein levels and risk of colorectal cancer : A case-control study nested in the Japan Collaborative Cohort Study. / Suzuki, Koji; Ito, Yoshinori; Wakai, Kenji; Kawado, Miyuki; Hashimoto, Shuji; Toyoshima, Hideaki; Kojima, Masayo; Tokudome, Shinkan; Hayakawa, Norihiko; Watanabe, Yoshiyuki; Tamakoshi, Koji; Suzuki, Sadao; Ozasa, Kotaro; Tamakoshi, Akiko; Mori, M.; Motohashi, Y.; Tsuji, I.; Nakamura, Y.; Iso, H.; Mikami, H.; Inaba, Y.; Hoshiyama, Y.; Suzuki, H.; Shimizu, H.; Kikuchi, S.; Koizumi, A.; Kawamura, T.; Miki, T.; Date, C.; Sakata, K.; Nose, T.; Yoshimura, T.; Fukuda, K.; Okamoto, N.; Shio, H.; Ohno, Y.; Kitagawa, T.; Kuroki, T.; Tajima, K.; Shimamoto, T.; Tanaka, H.; Hisamichi, S.; Nakao, M.; Suzuki, T.; Hashimoto, T.; Ishibashi, T.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 13, No. 11, 01.11.2004, p. 1781-1787.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum oxidized low-density lipoprotein levels and risk of colorectal cancer

T2 - A case-control study nested in the Japan Collaborative Cohort Study

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Wakai, Kenji

AU - Kawado, Miyuki

AU - Hashimoto, Shuji

AU - Toyoshima, Hideaki

AU - Kojima, Masayo

AU - Tokudome, Shinkan

AU - Hayakawa, Norihiko

AU - Watanabe, Yoshiyuki

AU - Tamakoshi, Koji

AU - Suzuki, Sadao

AU - Ozasa, Kotaro

AU - Tamakoshi, Akiko

AU - Mori, M.

AU - Motohashi, Y.

AU - Tsuji, I.

AU - Nakamura, Y.

AU - Iso, H.

AU - Mikami, H.

AU - Inaba, Y.

AU - Hoshiyama, Y.

AU - Suzuki, H.

AU - Shimizu, H.

AU - Kikuchi, S.

AU - Koizumi, A.

AU - Kawamura, T.

AU - Miki, T.

AU - Date, C.

AU - Sakata, K.

AU - Nose, T.

AU - Yoshimura, T.

AU - Fukuda, K.

AU - Okamoto, N.

AU - Shio, H.

AU - Ohno, Y.

AU - Kitagawa, T.

AU - Kuroki, T.

AU - Tajima, K.

AU - Shimamoto, T.

AU - Tanaka, H.

AU - Hisamichi, S.

AU - Nakao, M.

AU - Suzuki, T.

AU - Hashimoto, T.

AU - Ishibashi, T.

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P trend = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P trend = 0.140). Further adjustment for serum total cholesterol and α-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P trend = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

AB - Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P trend = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P trend = 0.140). Further adjustment for serum total cholesterol and α-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P trend = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

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