Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study

Shogo Kikuchi, Kiyoko Yagyu, Yuki Obata, Lin Yingsong, Hiroshi Yatsuya, Yoshiharu Hoshiyama, Takaaki Kondo, Kiyoshi Sakata, Tetsuya Mizoue, Noritaka Tokui, Yoshihisa Fujino, Akiko Tamakoshi, Hideaki Toyoshima, Teruo Ishibashi, Norihiko Hayakawa, Takesumi Yoshimura, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu NakamuraHiroyasu Iso, Haruo Mikami, Yutaka Inaba, Hiroshi Suzuki, Hiroyuki Shimizu, Kenji Wakai, Shinkan Tokudome, Yoshinori Ito, Shuji Hashimoto, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population. Methods: Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan, Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy. Results: About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe scrological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age. Conclusions: The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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Pepsinogen A
Helicobacter pylori
Case-Control Studies
Pepsinogen C
Atrophy
Serum
Helicobacter Infections
Stomach Neoplasms
Japan
Seroepidemiologic Studies
Rural Population
Gastric Mucosa
Antibodies

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Kikuchi, Shogo ; Yagyu, Kiyoko ; Obata, Yuki ; Yingsong, Lin ; Yatsuya, Hiroshi ; Hoshiyama, Yoshiharu ; Kondo, Takaaki ; Sakata, Kiyoshi ; Mizoue, Tetsuya ; Tokui, Noritaka ; Fujino, Yoshihisa ; Tamakoshi, Akiko ; Toyoshima, Hideaki ; Ishibashi, Teruo ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Wakai, Kenji ; Tokudome, Shinkan ; Ito, Yoshinori ; Hashimoto, Shuji ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
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title = "Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study",
abstract = "Background: Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population. Methods: Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan, Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy. Results: About 70{\%} of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe scrological atrophy increased with age from 10{\%} in those aged 40-49 years to 38{\%} in 70 and more, and percentages of those with mild serological atrophy were about 30{\%} independent of age. Conclusions: The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.",
author = "Shogo Kikuchi and Kiyoko Yagyu and Yuki Obata and Lin Yingsong and Hiroshi Yatsuya and Yoshiharu Hoshiyama and Takaaki Kondo and Kiyoshi Sakata and Tetsuya Mizoue and Noritaka Tokui and Yoshihisa Fujino and Akiko Tamakoshi and Hideaki Toyoshima and Teruo Ishibashi and Norihiko Hayakawa and Takesumi Yoshimura and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Hiroshi Suzuki and Hiroyuki Shimizu and Kenji Wakai and Shinkan Tokudome and Yoshinori Ito and Shuji Hashimoto and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
year = "2005",
month = "10",
day = "14",
doi = "10.2188/jea.15.S126",
language = "English",
volume = "15",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "SUPPL. 2",

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Kikuchi, S, Yagyu, K, Obata, Y, Yingsong, L, Yatsuya, H, Hoshiyama, Y, Kondo, T, Sakata, K, Mizoue, T, Tokui, N, Fujino, Y, Tamakoshi, A, Toyoshima, H, Ishibashi, T, Hayakawa, N, Yoshimura, T, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Suzuki, H, Shimizu, H, Wakai, K, Tokudome, S, Ito, Y, Hashimoto, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2005, 'Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S126

Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. / Kikuchi, Shogo; Yagyu, Kiyoko; Obata, Yuki; Yingsong, Lin; Yatsuya, Hiroshi; Hoshiyama, Yoshiharu; Kondo, Takaaki; Sakata, Kiyoshi; Mizoue, Tetsuya; Tokui, Noritaka; Fujino, Yoshihisa; Tamakoshi, Akiko; Toyoshima, Hideaki; Ishibashi, Teruo; Hayakawa, Norihiko; Yoshimura, Takesumi; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Suzuki, Hiroshi; Shimizu, Hiroyuki; Wakai, Kenji; Tokudome, Shinkan; Ito, Yoshinori; Hashimoto, Shuji; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study

AU - Kikuchi, Shogo

AU - Yagyu, Kiyoko

AU - Obata, Yuki

AU - Yingsong, Lin

AU - Yatsuya, Hiroshi

AU - Hoshiyama, Yoshiharu

AU - Kondo, Takaaki

AU - Sakata, Kiyoshi

AU - Mizoue, Tetsuya

AU - Tokui, Noritaka

AU - Fujino, Yoshihisa

AU - Tamakoshi, Akiko

AU - Toyoshima, Hideaki

AU - Ishibashi, Teruo

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population. Methods: Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan, Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy. Results: About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe scrological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age. Conclusions: The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.

AB - Background: Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population. Methods: Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan, Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy. Results: About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe scrological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age. Conclusions: The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.

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DO - 10.2188/jea.15.S126

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JO - Journal of Epidemiology

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