Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases

Hiroshi Yatsuya, Koji Tamakoshi, Hiroaki Hattori, Rei Otsuka, Keiko Wada, Huiming Zhang, Tomoko Mabuchi, Miyuki Ishikawa, Chiyoe Murata, Tsutomu Yoshida, Takaaki Kondo, Hideaki Toyoshima

Research output: Contribution to journalArticle

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Abstract

Background: Phospholipid transfer protein (PLTP) can generate pre-β high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. Methods and Results: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized β=0.395, -0.191, -0.064, and -0.064, respectively; R 2=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. Conclusions: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalCirculation Journal
Volume68
Issue number1
DOIs
Publication statusPublished - 01-01-2004

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Phospholipid Transfer Proteins
Coronary Disease
Blood Proteins
HDL Lipoproteins
HDL Cholesterol
Phospholipids
Triglycerides
Stroke
Cholesterol
Protective Factors
Workplace
LDL Cholesterol
Linear Models
Body Mass Index
Cardiovascular Diseases
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Prospective Studies
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Yatsuya, Hiroshi ; Tamakoshi, Koji ; Hattori, Hiroaki ; Otsuka, Rei ; Wada, Keiko ; Zhang, Huiming ; Mabuchi, Tomoko ; Ishikawa, Miyuki ; Murata, Chiyoe ; Yoshida, Tsutomu ; Kondo, Takaaki ; Toyoshima, Hideaki. / Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases. In: Circulation Journal. 2004 ; Vol. 68, No. 1. pp. 11-16.
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abstract = "Background: Phospholipid transfer protein (PLTP) can generate pre-β high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. Methods and Results: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized β=0.395, -0.191, -0.064, and -0.064, respectively; R 2=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95{\%} confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. Conclusions: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.",
author = "Hiroshi Yatsuya and Koji Tamakoshi and Hiroaki Hattori and Rei Otsuka and Keiko Wada and Huiming Zhang and Tomoko Mabuchi and Miyuki Ishikawa and Chiyoe Murata and Tsutomu Yoshida and Takaaki Kondo and Hideaki Toyoshima",
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Yatsuya, H, Tamakoshi, K, Hattori, H, Otsuka, R, Wada, K, Zhang, H, Mabuchi, T, Ishikawa, M, Murata, C, Yoshida, T, Kondo, T & Toyoshima, H 2004, 'Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases', Circulation Journal, vol. 68, no. 1, pp. 11-16. https://doi.org/10.1253/circj.68.11

Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases. / Yatsuya, Hiroshi; Tamakoshi, Koji; Hattori, Hiroaki; Otsuka, Rei; Wada, Keiko; Zhang, Huiming; Mabuchi, Tomoko; Ishikawa, Miyuki; Murata, Chiyoe; Yoshida, Tsutomu; Kondo, Takaaki; Toyoshima, Hideaki.

In: Circulation Journal, Vol. 68, No. 1, 01.01.2004, p. 11-16.

Research output: Contribution to journalArticle

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T1 - Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Hattori, Hiroaki

AU - Otsuka, Rei

AU - Wada, Keiko

AU - Zhang, Huiming

AU - Mabuchi, Tomoko

AU - Ishikawa, Miyuki

AU - Murata, Chiyoe

AU - Yoshida, Tsutomu

AU - Kondo, Takaaki

AU - Toyoshima, Hideaki

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background: Phospholipid transfer protein (PLTP) can generate pre-β high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. Methods and Results: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized β=0.395, -0.191, -0.064, and -0.064, respectively; R 2=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. Conclusions: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

AB - Background: Phospholipid transfer protein (PLTP) can generate pre-β high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. Methods and Results: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized β=0.395, -0.191, -0.064, and -0.064, respectively; R 2=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. Conclusions: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

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