Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men

Kotaro Ozasa; Masahiro Nakao; Yoshiyuki Watanabe; Kyohei Hayashi; Tsuneharu Miki; Kazuya Mikami; Mitsuru Mori; Fumio Sakauchi; Masakazu Washio; Yoshinori Ito; Koji Suzuki; Kenji Wakai; Akiko Tamakoshi; Haruo Sugano; A. Tamakoshi; Y. Ohno; Y. Motohashi; I. Tsuji; Y. Nakamura; H. Iso; H. Mikami; Y. Inaba; Y. Hoshiyama; H. Suzuki; H. Shimizu; H. Toyoshima; S. Tokudome; S. Hashimoto; S. Kikuchi; A. Koizumi; T. Kawamura; C. Date; K. Sakata; T. Nose; N. Hayakawa; T. Yoshimura; K. Fukuda; N. Okamoto; H. Shio; T. Kitagawa; T. Kuroki; K. Tajima; T. Shimamoto; H. Tanaka; S. Hisamichi; T. Suzuki; T. Hashimoto; T. Ishibashi

doi:10.1111/j.1349-7006.2004.tb03172.x

Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men

Kotaro Ozasa, Masahiro Nakao, Yoshiyuki Watanabe, Kyohei Hayashi, Tsuneharu Miki, Kazuya Mikami, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Yoshinori Ito, Koji Suzuki, Kenji Wakai, Akiko Tamakoshi, Haruo Sugano, A. Tamakoshi, Y. Ohno, Y. Motohashi, I. Tsuji, Y. Nakamura, H. IsoH. Mikami, Y. Inaba, Y. Hoshiyama, H. Suzuki, H. Shimizu, H. Toyoshima, S. Tokudome, S. Hashimoto, S. Kikuchi, A. Koizumi, T. Kawamura, C. Date, K. Sakata, T. Nose, N. Hayakawa, T. Yoshimura, K. Fukuda, N. Okamoto, H. Shio, T. Kitagawa, T. Kuroki, K. Tajima, T. Shimamoto, H. Tanaka, S. Hisamichi, T. Suzuki, T. Hashimoto, T. Ishibashi

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Abstract

The purpose of this study was to examine whether a high serum concentration of phytoestrogens reduces the risk of prostate cancer in a case-control study nested in a community-based cohort in Japan (Japan Collaborative Cohort (JACC) Study). Information on lifestyles and sera of the subjects were collected in 1988-90, and they were followed up to 1999. Incident and dead cases of prostate cancer and controls were matched for study area and age. Phytoestrogens and sex hormones in sera stored at -80°C were measured in 2002. Of 14,105 male subjects of the cohort who donated their sera, 52 cases and 151 controls were identified. Three datasets were analyzed; 1) all subjects, 2) 40 cases and 101 controls after excluding subjects with low testosterone levels who were suspected of having had medical intervention, and 3) 28 cases and 69 controls with prostate specific antigen level of ≤10.0 ng/ml. The odds ratio (OR) for the highest level to the lowest was 0.38 (95% confidence interval (CI); 0.13, 1.13) for genistein, 0.41 (0.15, 1.11) for daidzein, and 0.34 (0.11, 1.10) for equol for the second dataset. Genistein and daidzein showed similar findings in the third one. Equol and equol/daidzein ratio showed consistent findings in all three datasets (OR=0.39, 95% CI; 0.13, 0.89, trend P=0.02 for the first dataset). Their effects seemed to be independent of serum sex hormones. In conclusion, serum genistein, daidzein, and equol seemed to dose-dependently reduce prostate cancer risk.

Original language	English
Pages (from-to)	65-71
Number of pages	7
Journal	Cancer science
Volume	95
Issue number	1
DOIs	https://doi.org/10.1111/j.1349-7006.2004.tb03172.x
Publication status	Published - 01-2004

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2004.tb03172.x

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Ozasa, K., Nakao, M., Watanabe, Y., Hayashi, K., Miki, T., Mikami, K., Mori, M., Sakauchi, F., Washio, M., Ito, Y., Suzuki, K., Wakai, K., Tamakoshi, A., Sugano, H., Tamakoshi, A., Ohno, Y., Motohashi, Y., Tsuji, I., Nakamura, Y., ... Ishibashi, T. (2004). Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men. Cancer science, 95(1), 65-71. https://doi.org/10.1111/j.1349-7006.2004.tb03172.x

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title = "Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men",

abstract = "The purpose of this study was to examine whether a high serum concentration of phytoestrogens reduces the risk of prostate cancer in a case-control study nested in a community-based cohort in Japan (Japan Collaborative Cohort (JACC) Study). Information on lifestyles and sera of the subjects were collected in 1988-90, and they were followed up to 1999. Incident and dead cases of prostate cancer and controls were matched for study area and age. Phytoestrogens and sex hormones in sera stored at -80°C were measured in 2002. Of 14,105 male subjects of the cohort who donated their sera, 52 cases and 151 controls were identified. Three datasets were analyzed; 1) all subjects, 2) 40 cases and 101 controls after excluding subjects with low testosterone levels who were suspected of having had medical intervention, and 3) 28 cases and 69 controls with prostate specific antigen level of ≤10.0 ng/ml. The odds ratio (OR) for the highest level to the lowest was 0.38 (95% confidence interval (CI); 0.13, 1.13) for genistein, 0.41 (0.15, 1.11) for daidzein, and 0.34 (0.11, 1.10) for equol for the second dataset. Genistein and daidzein showed similar findings in the third one. Equol and equol/daidzein ratio showed consistent findings in all three datasets (OR=0.39, 95% CI; 0.13, 0.89, trend P=0.02 for the first dataset). Their effects seemed to be independent of serum sex hormones. In conclusion, serum genistein, daidzein, and equol seemed to dose-dependently reduce prostate cancer risk.",

author = "Kotaro Ozasa and Masahiro Nakao and Yoshiyuki Watanabe and Kyohei Hayashi and Tsuneharu Miki and Kazuya Mikami and Mitsuru Mori and Fumio Sakauchi and Masakazu Washio and Yoshinori Ito and Koji Suzuki and Kenji Wakai and Akiko Tamakoshi and Haruo Sugano and A. Tamakoshi and Y. Ohno and Y. Motohashi and I. Tsuji and Y. Nakamura and H. Iso and H. Mikami and Y. Inaba and Y. Hoshiyama and H. Suzuki and H. Shimizu and H. Toyoshima and S. Tokudome and S. Hashimoto and S. Kikuchi and A. Koizumi and T. Kawamura and C. Date and K. Sakata and T. Nose and N. Hayakawa and T. Yoshimura and K. Fukuda and N. Okamoto and H. Shio and T. Kitagawa and T. Kuroki and K. Tajima and T. Shimamoto and H. Tanaka and S. Hisamichi and T. Suzuki and T. Hashimoto and T. Ishibashi",

year = "2004",

month = jan,

doi = "10.1111/j.1349-7006.2004.tb03172.x",

language = "English",

volume = "95",

pages = "65--71",

journal = "Cancer science",

issn = "1347-9032",

publisher = "Wiley-Blackwell",

number = "1",

}

Ozasa, K, Nakao, M, Watanabe, Y, Hayashi, K, Miki, T, Mikami, K, Mori, M, Sakauchi, F, Washio, M, Ito, Y, Suzuki, K, Wakai, K, Tamakoshi, A, Sugano, H, Tamakoshi, A, Ohno, Y, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Hashimoto, S, Kikuchi, S, Koizumi, A, Kawamura, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Fukuda, K, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T, Tajima, K, Shimamoto, T, Tanaka, H, Hisamichi, S, Suzuki, T, Hashimoto, T & Ishibashi, T 2004, 'Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men', Cancer science, vol. 95, no. 1, pp. 65-71. https://doi.org/10.1111/j.1349-7006.2004.tb03172.x

TY - JOUR

T1 - Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men

AU - Ozasa, Kotaro

AU - Nakao, Masahiro

AU - Watanabe, Yoshiyuki

AU - Hayashi, Kyohei

AU - Miki, Tsuneharu

AU - Mikami, Kazuya

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Washio, Masakazu

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Wakai, Kenji

AU - Tamakoshi, Akiko

AU - Sugano, Haruo

AU - Tamakoshi, A.

AU - Ohno, Y.

AU - Motohashi, Y.

AU - Tsuji, I.

AU - Nakamura, Y.

AU - Iso, H.

AU - Mikami, H.

AU - Inaba, Y.

AU - Hoshiyama, Y.

AU - Suzuki, H.

AU - Shimizu, H.

AU - Toyoshima, H.

AU - Tokudome, S.

AU - Hashimoto, S.

AU - Kikuchi, S.

AU - Koizumi, A.

AU - Kawamura, T.

AU - Date, C.

AU - Sakata, K.

AU - Nose, T.

AU - Hayakawa, N.

AU - Yoshimura, T.

AU - Fukuda, K.

AU - Okamoto, N.

AU - Shio, H.

AU - Kitagawa, T.

AU - Kuroki, T.

AU - Tajima, K.

AU - Shimamoto, T.

AU - Tanaka, H.

AU - Hisamichi, S.

AU - Suzuki, T.

AU - Hashimoto, T.

AU - Ishibashi, T.

PY - 2004/1

Y1 - 2004/1

N2 - The purpose of this study was to examine whether a high serum concentration of phytoestrogens reduces the risk of prostate cancer in a case-control study nested in a community-based cohort in Japan (Japan Collaborative Cohort (JACC) Study). Information on lifestyles and sera of the subjects were collected in 1988-90, and they were followed up to 1999. Incident and dead cases of prostate cancer and controls were matched for study area and age. Phytoestrogens and sex hormones in sera stored at -80°C were measured in 2002. Of 14,105 male subjects of the cohort who donated their sera, 52 cases and 151 controls were identified. Three datasets were analyzed; 1) all subjects, 2) 40 cases and 101 controls after excluding subjects with low testosterone levels who were suspected of having had medical intervention, and 3) 28 cases and 69 controls with prostate specific antigen level of ≤10.0 ng/ml. The odds ratio (OR) for the highest level to the lowest was 0.38 (95% confidence interval (CI); 0.13, 1.13) for genistein, 0.41 (0.15, 1.11) for daidzein, and 0.34 (0.11, 1.10) for equol for the second dataset. Genistein and daidzein showed similar findings in the third one. Equol and equol/daidzein ratio showed consistent findings in all three datasets (OR=0.39, 95% CI; 0.13, 0.89, trend P=0.02 for the first dataset). Their effects seemed to be independent of serum sex hormones. In conclusion, serum genistein, daidzein, and equol seemed to dose-dependently reduce prostate cancer risk.

AB - The purpose of this study was to examine whether a high serum concentration of phytoestrogens reduces the risk of prostate cancer in a case-control study nested in a community-based cohort in Japan (Japan Collaborative Cohort (JACC) Study). Information on lifestyles and sera of the subjects were collected in 1988-90, and they were followed up to 1999. Incident and dead cases of prostate cancer and controls were matched for study area and age. Phytoestrogens and sex hormones in sera stored at -80°C were measured in 2002. Of 14,105 male subjects of the cohort who donated their sera, 52 cases and 151 controls were identified. Three datasets were analyzed; 1) all subjects, 2) 40 cases and 101 controls after excluding subjects with low testosterone levels who were suspected of having had medical intervention, and 3) 28 cases and 69 controls with prostate specific antigen level of ≤10.0 ng/ml. The odds ratio (OR) for the highest level to the lowest was 0.38 (95% confidence interval (CI); 0.13, 1.13) for genistein, 0.41 (0.15, 1.11) for daidzein, and 0.34 (0.11, 1.10) for equol for the second dataset. Genistein and daidzein showed similar findings in the third one. Equol and equol/daidzein ratio showed consistent findings in all three datasets (OR=0.39, 95% CI; 0.13, 0.89, trend P=0.02 for the first dataset). Their effects seemed to be independent of serum sex hormones. In conclusion, serum genistein, daidzein, and equol seemed to dose-dependently reduce prostate cancer risk.

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DO - 10.1111/j.1349-7006.2004.tb03172.x

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SN - 1347-9032

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JO - Cancer science

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ER -

Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men

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