Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study

Yingsong Lin; Shogo Kikuchi; Kiyoko Yagyu; Teruo Ishibashi; Michiko Kurosawa; Yoshinori Ito; Yoshiyuki Watanabe; Yutaka Inaba; Kazuo Tajima; Kei Nakachi; Akiko Tamakoshi; Mitsuru Mori; Fumio Sakauchi; Yutaka Motohashi; Ichiro Tsuji; Yosikazu Nakamura; Hiroyasu Iso; Haruo Mikami; Yoshiharu Hoshiyama; Naohito Tanabe; Koji Tamakoshi; Kenji Wakai; Shinkan Tokudome; Shuji Hashimoto; Yasuhiko Wada; Takashi Kawamura; Kotaro Ozasa; Tsuneharu Miki; Chigusa Date; Kiyomi Sakata; Yoichi Kurozawa; Takesumi Yoshimura; Yoshihisa Fujino; Akira Shibata; Naoyuki Okamoto; Hideo Shio

Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study

Yingsong Lin, Shogo Kikuchi, Kiyoko Yagyu, Teruo Ishibashi, Michiko Kurosawa, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yoshiharu Hoshiyama, Naohito TanabeKoji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shuji Hashimoto, Yasuhiko Wada, Takashi Kawamura, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Hygiene

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In a search for novel circulating biomarkers for pancreatic cancer, we examined the association between serum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreatic cancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68 persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequently died from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who were selected from the remaining participants in the cohort. Conditional logistic regression models were used to estimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) between cases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreatic cancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, no significant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SOD activity are associated with pancreatic cancer risk.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Asian Pacific Journal of Cancer Prevention
Volume	10
Issue number	SUPPL.1
Publication status	Published - 01-12-2009

All Science Journal Classification (ASJC) codes

Epidemiology
Oncology
Public Health, Environmental and Occupational Health
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Lin, Y., Kikuchi, S., Yagyu, K., Ishibashi, T., Kurosawa, M., Ito, Y., Watanabe, Y., Inaba, Y., Tajima, K., Nakachi, K., Tamakoshi, A., Mori, M., Sakauchi, F., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Hoshiyama, Y., ... Shio, H. (2009). Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study. Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 81-86.

@article{6dfcb7edd0d741a5bb336d23492304ae,

title = "Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study",

abstract = "In a search for novel circulating biomarkers for pancreatic cancer, we examined the association between serum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreatic cancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68 persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequently died from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who were selected from the remaining participants in the cohort. Conditional logistic regression models were used to estimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) between cases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreatic cancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, no significant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SOD activity are associated with pancreatic cancer risk.",

author = "Yingsong Lin and Shogo Kikuchi and Kiyoko Yagyu and Teruo Ishibashi and Michiko Kurosawa and Yoshinori Ito and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Kei Nakachi and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Kenji Wakai and Shinkan Tokudome and Shuji Hashimoto and Yasuhiko Wada and Takashi Kawamura and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",

year = "2009",

month = dec,

day = "1",

language = "English",

volume = "10",

pages = "81--86",

journal = "Asian Pacific Journal of Cancer Prevention",

issn = "1513-7368",

publisher = "Asian Pacific Organization for Cancer Prevention",

number = "SUPPL.1",

}

Lin, Y, Kikuchi, S, Yagyu, K, Ishibashi, T, Kurosawa, M, Ito, Y, Watanabe, Y, Inaba, Y, Tajima, K, Nakachi, K, Tamakoshi, A, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Wakai, K, Tokudome, S, Hashimoto, S, Wada, Y, Kawamura, T, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 81-86.

TY - JOUR

T1 - Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer

T2 - A Nested Casecontrol Study within the JACC Study

AU - Lin, Yingsong

AU - Kikuchi, Shogo

AU - Yagyu, Kiyoko

AU - Ishibashi, Teruo

AU - Kurosawa, Michiko

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/12/1

Y1 - 2009/12/1

N2 - In a search for novel circulating biomarkers for pancreatic cancer, we examined the association between serum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreatic cancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68 persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequently died from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who were selected from the remaining participants in the cohort. Conditional logistic regression models were used to estimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) between cases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreatic cancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, no significant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SOD activity are associated with pancreatic cancer risk.

AB - In a search for novel circulating biomarkers for pancreatic cancer, we examined the association between serum soluble Fas (sFas) levels and superoxide dismutase (SOD) activity and the risk of death from pancreatic cancer in a nested case-control study within the Japanese Collaborative Cohort Study. Case subjects were 68 persons who were free of morbidity, had provided a blood sample at baseline (1988-1990), and subsequently died from pancreatic cancer before December 31, 1997. Control subjects were 199 matched persons who were selected from the remaining participants in the cohort. Conditional logistic regression models were used to estimate age-adjusted and multivariate-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). No statistically significant differences were noted in mean sFas levels (p=0.11) and SOD activity (p=0.42) between cases and controls. Overall, neither serum sFas levels nor SOD activity were associated with the risk of pancreatic cancer deaths, after adjustment for area, BMI, cigarette smoking, and history of diabetes. Furthermore, no significant risk trends were noted. Our results do not support the hypothesis that serum sFas levels and SOD activity are associated with pancreatic cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=77957373584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957373584&partnerID=8YFLogxK

M3 - Article

C2 - 20553087

AN - SCOPUS:77957373584

SN - 1513-7368

VL - 10

SP - 81

EP - 86

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

IS - SUPPL.1

ER -

Serum Soluble Fas Levels and Superoxide Dismutase Activity and the Risk of Death from Pancreatic Cancer: A Nested Casecontrol Study within the JACC Study

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Other files and links

Fingerprint

Cite this