TY - JOUR
T1 - Severe hepatitis associated with varicella zoster virus infection in a patient with diffuse large B cell lymphoma treated with rituximab-CHOP chemotherapy
AU - Okamoto, Akinao
AU - Abe, Akihiro
AU - Okamoto, Masataka
AU - Kobayashi, Tsukane
AU - Terazawa, Tomohiko
AU - Inaguma, Yoko
AU - Tokuda, Masutaka
AU - Yanada, Masamitsu
AU - Morishima, Satoko
AU - Kanie, Tadaharu
AU - Yamamoto, Yukiya
AU - Tsuzuki, Motohiro
AU - Akatsuka, Yoshiki
AU - Mizuta, Shuichi
AU - Yoshikawa, Tetsushi
AU - Emi, Nobuhiko
N1 - Funding Information:
Acknowledgments This work was supported by a grant-in-aid from Fujita Health University. We sincerely thank Akiko Yoshikawa, Sac-hiko Tsuzuki, and Akemi Endo for their valuable laboratory assistance.
PY - 2012/10
Y1 - 2012/10
N2 - Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma (DLBCL) patient treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). The patient was an 82-year-old male with DLBCL who had a history of type II diabetes mellitus. He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of R-CHOP. When the VZV infection occurred, anti-VZV IgG was not detected and lymphopenia was observed. We initiated treatment with acyclovir, immunoglobulin, and thrombomodulin alpha, and rescued this patient. We suggest that the use of chemotherapy for immune-suppressed elderly lymphoma patients may involve the risk of severe VZV infection.
AB - Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma (DLBCL) patient treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). The patient was an 82-year-old male with DLBCL who had a history of type II diabetes mellitus. He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of R-CHOP. When the VZV infection occurred, anti-VZV IgG was not detected and lymphopenia was observed. We initiated treatment with acyclovir, immunoglobulin, and thrombomodulin alpha, and rescued this patient. We suggest that the use of chemotherapy for immune-suppressed elderly lymphoma patients may involve the risk of severe VZV infection.
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U2 - 10.1007/s12185-012-1160-4
DO - 10.1007/s12185-012-1160-4
M3 - Article
C2 - 22903849
AN - SCOPUS:84868096800
VL - 96
SP - 516
EP - 520
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 4
ER -