Abstract
Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma (DLBCL) patient treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). The patient was an 82-year-old male with DLBCL who had a history of type II diabetes mellitus. He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of R-CHOP. When the VZV infection occurred, anti-VZV IgG was not detected and lymphopenia was observed. We initiated treatment with acyclovir, immunoglobulin, and thrombomodulin alpha, and rescued this patient. We suggest that the use of chemotherapy for immune-suppressed elderly lymphoma patients may involve the risk of severe VZV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 516-520 |
| Number of pages | 5 |
| Journal | International Journal of Hematology |
| Volume | 96 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-10-2012 |
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All Science Journal Classification (ASJC) codes
- Hematology
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Severe hepatitis associated with varicella zoster virus infection in a patient with diffuse large B cell lymphoma treated with rituximab-CHOP chemotherapy. / Okamoto, Akinao; Abe, Akihiro; Okamoto, Masataka; Kobayashi, Tsukane; Terazawa, Tomohiko; Inaguma, Yoko; Tokuda, Masutaka; Yanada, Masamitsu; Morishima, Satoko; Kanie, Tadaharu; Yamamoto, Yukiya; Tsuzuki, Motohiro; Akatsuka, Yoshiki; Mizuta, Shuichi; Yoshikawa, Tetsushi; Emi, Nobuhiko.
In: International Journal of Hematology, Vol. 96, No. 4, 01.10.2012, p. 516-520.Research output: Contribution to journal › Article
TY - JOUR
T1 - Severe hepatitis associated with varicella zoster virus infection in a patient with diffuse large B cell lymphoma treated with rituximab-CHOP chemotherapy
AU - Okamoto, Akinao
AU - Abe, Akihiro
AU - Okamoto, Masataka
AU - Kobayashi, Tsukane
AU - Terazawa, Tomohiko
AU - Inaguma, Yoko
AU - Tokuda, Masutaka
AU - Yanada, Masamitsu
AU - Morishima, Satoko
AU - Kanie, Tadaharu
AU - Yamamoto, Yukiya
AU - Tsuzuki, Motohiro
AU - Akatsuka, Yoshiki
AU - Mizuta, Shuichi
AU - Yoshikawa, Tetsushi
AU - Emi, Nobuhiko
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma (DLBCL) patient treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). The patient was an 82-year-old male with DLBCL who had a history of type II diabetes mellitus. He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of R-CHOP. When the VZV infection occurred, anti-VZV IgG was not detected and lymphopenia was observed. We initiated treatment with acyclovir, immunoglobulin, and thrombomodulin alpha, and rescued this patient. We suggest that the use of chemotherapy for immune-suppressed elderly lymphoma patients may involve the risk of severe VZV infection.
AB - Severe disseminated varicella zoster virus (VZV) infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation. This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma (DLBCL) patient treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). The patient was an 82-year-old male with DLBCL who had a history of type II diabetes mellitus. He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of R-CHOP. When the VZV infection occurred, anti-VZV IgG was not detected and lymphopenia was observed. We initiated treatment with acyclovir, immunoglobulin, and thrombomodulin alpha, and rescued this patient. We suggest that the use of chemotherapy for immune-suppressed elderly lymphoma patients may involve the risk of severe VZV infection.
UR - http://www.scopus.com/inward/record.url?scp=84868096800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868096800&partnerID=8YFLogxK
U2 - 10.1007/s12185-012-1160-4
DO - 10.1007/s12185-012-1160-4
M3 - Article
VL - 96
SP - 516
EP - 520
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 4
ER -