Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B

T. Kato, M. Itoh, J. Hanashita, T. Itoi, T. Matsumoto, Y. Ono, S. Imamura, N. Hayakawa, Atsushi Suzuki, Y. Mizutani, Y. Uchigata, N. Oda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aims: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.

Original languageEnglish
Pages (from-to)1279-1281
Number of pages3
JournalDiabetic Medicine
Volume24
Issue number11
DOIs
Publication statusPublished - 01-11-2007

Fingerprint

Insulin Receptor
Hypoglycemia
Insulin Antibodies
Insulin
Steroids
HLA-DR Antigens
Lymphocyte Activation
Prednisolone
Hypoglycemic Agents
Pharmaceutical Preparations
Autoantibodies
Antibody Formation
Therapeutics
Antibodies

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kato, T. ; Itoh, M. ; Hanashita, J. ; Itoi, T. ; Matsumoto, T. ; Ono, Y. ; Imamura, S. ; Hayakawa, N. ; Suzuki, Atsushi ; Mizutani, Y. ; Uchigata, Y. ; Oda, N. / Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. In: Diabetic Medicine. 2007 ; Vol. 24, No. 11. pp. 1279-1281.
@article{a0700b6bad8d4d248f4d1bca6bcdf6b4,
title = "Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B",
abstract = "Aims: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results: Titers of antibody to insulin and insulin receptors were 73.0{\%} and 41.5{\%}, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.",
author = "T. Kato and M. Itoh and J. Hanashita and T. Itoi and T. Matsumoto and Y. Ono and S. Imamura and N. Hayakawa and Atsushi Suzuki and Y. Mizutani and Y. Uchigata and N. Oda",
year = "2007",
month = "11",
day = "1",
doi = "10.1111/j.1464-5491.2007.02232.x",
language = "English",
volume = "24",
pages = "1279--1281",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "11",

}

Kato, T, Itoh, M, Hanashita, J, Itoi, T, Matsumoto, T, Ono, Y, Imamura, S, Hayakawa, N, Suzuki, A, Mizutani, Y, Uchigata, Y & Oda, N 2007, 'Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B', Diabetic Medicine, vol. 24, no. 11, pp. 1279-1281. https://doi.org/10.1111/j.1464-5491.2007.02232.x

Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. / Kato, T.; Itoh, M.; Hanashita, J.; Itoi, T.; Matsumoto, T.; Ono, Y.; Imamura, S.; Hayakawa, N.; Suzuki, Atsushi; Mizutani, Y.; Uchigata, Y.; Oda, N.

In: Diabetic Medicine, Vol. 24, No. 11, 01.11.2007, p. 1279-1281.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B

AU - Kato, T.

AU - Itoh, M.

AU - Hanashita, J.

AU - Itoi, T.

AU - Matsumoto, T.

AU - Ono, Y.

AU - Imamura, S.

AU - Hayakawa, N.

AU - Suzuki, Atsushi

AU - Mizutani, Y.

AU - Uchigata, Y.

AU - Oda, N.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Aims: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.

AB - Aims: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. Methods: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. Results: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. Conclusions: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy.

UR - http://www.scopus.com/inward/record.url?scp=35449001707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35449001707&partnerID=8YFLogxK

U2 - 10.1111/j.1464-5491.2007.02232.x

DO - 10.1111/j.1464-5491.2007.02232.x

M3 - Article

C2 - 17956452

AN - SCOPUS:35449001707

VL - 24

SP - 1279

EP - 1281

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 11

ER -