Severe visual impairment and subclinical encephalitis preceding clinical signs of chondritis in relapsing polychondritis

Ryoji Miyano, Masanori Kurihara, Kenta Orimo, Tatsuo Mano, Toshikatsu Kaburaki, Rie Tanaka, Hironobu Nishijima, Masako Ikemura, Miwako Takahashi, Harushi Mori, Tatsuro Mutoh, Masashi Hamada, Toshihiro Hayashi, Tatsushi Toda

Research output: Contribution to journalArticlepeer-review

Abstract

A 71-year-old woman with a 6-month history of relapsing bilateral anterior scleritis presented with severe right visual impairment due to posterior scleritis. Despite radiological signs of encephalitis, the patient and her family members noticed no cognitive decline. The patient subsequently developed slight auricular pain without any visual changes such as redness or swelling, which, however, showed increased uptake of 18F-fluorodeoxyglucose on positron emission tomography. Auricular cartilage biopsy revealed perichondrial inflammation suggesting relapsing polychondritis. Steroid therapy improved her symptoms and radiological findings. This case illustrates that asymptomatic brain inflammatory lesions can precede clinical signs of chondritis in relapsing polychondritis, and that auricular cartilage biopsy should be considered even with mild auricular pain without apparent clinical findings of inflammation.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalNeurology and Clinical Neuroscience
Volume7
Issue number2
DOIs
Publication statusPublished - 03-2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Severe visual impairment and subclinical encephalitis preceding clinical signs of chondritis in relapsing polychondritis'. Together they form a unique fingerprint.

Cite this