TY - JOUR
T1 - Severe visual impairment and subclinical encephalitis preceding clinical signs of chondritis in relapsing polychondritis
AU - Miyano, Ryoji
AU - Kurihara, Masanori
AU - Orimo, Kenta
AU - Mano, Tatsuo
AU - Kaburaki, Toshikatsu
AU - Tanaka, Rie
AU - Nishijima, Hironobu
AU - Ikemura, Masako
AU - Takahashi, Miwako
AU - Mori, Harushi
AU - Mutoh, Tatsuro
AU - Hamada, Masashi
AU - Hayashi, Toshihiro
AU - Toda, Tatsushi
N1 - Publisher Copyright:
© 2018 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd
PY - 2019/3
Y1 - 2019/3
N2 - A 71-year-old woman with a 6-month history of relapsing bilateral anterior scleritis presented with severe right visual impairment due to posterior scleritis. Despite radiological signs of encephalitis, the patient and her family members noticed no cognitive decline. The patient subsequently developed slight auricular pain without any visual changes such as redness or swelling, which, however, showed increased uptake of 18F-fluorodeoxyglucose on positron emission tomography. Auricular cartilage biopsy revealed perichondrial inflammation suggesting relapsing polychondritis. Steroid therapy improved her symptoms and radiological findings. This case illustrates that asymptomatic brain inflammatory lesions can precede clinical signs of chondritis in relapsing polychondritis, and that auricular cartilage biopsy should be considered even with mild auricular pain without apparent clinical findings of inflammation.
AB - A 71-year-old woman with a 6-month history of relapsing bilateral anterior scleritis presented with severe right visual impairment due to posterior scleritis. Despite radiological signs of encephalitis, the patient and her family members noticed no cognitive decline. The patient subsequently developed slight auricular pain without any visual changes such as redness or swelling, which, however, showed increased uptake of 18F-fluorodeoxyglucose on positron emission tomography. Auricular cartilage biopsy revealed perichondrial inflammation suggesting relapsing polychondritis. Steroid therapy improved her symptoms and radiological findings. This case illustrates that asymptomatic brain inflammatory lesions can precede clinical signs of chondritis in relapsing polychondritis, and that auricular cartilage biopsy should be considered even with mild auricular pain without apparent clinical findings of inflammation.
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U2 - 10.1111/ncn3.12243
DO - 10.1111/ncn3.12243
M3 - Article
AN - SCOPUS:85177716975
SN - 2049-4173
VL - 7
SP - 75
EP - 77
JO - Neurology and Clinical Neuroscience
JF - Neurology and Clinical Neuroscience
IS - 2
ER -