Severity of viremia and clinical findings in children with Varicella

Yoshizo Asano, Naoko Itakura, Yuji Kajita, Sadao Suga, Tetsushi Yoshikawa, Thkehiko Yazaki, Thkao Ozaki, Koichi Yamanishi, Michiaki Takahashi

Research output: Contribution to journalArticle

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Abstract

The number of varicella zoster virus-infected mononuclear cells in blood samples obtained during 3 days before appearance of vesicular skin rashes could be estimated in 13 of 21 immunocompetent children with varicella and viremia (range, 1-83 per 107 mononuclear cells). The virus was isolated from 5% of adherent cells (1/21),71% ofnonadherent cells (12/17),43% ofT lymphocytes (9/21), and 33% ofB lymphocytes (7/21). The number of vesicleson the body correlated with the maximum body temperature, duration of fever, and number of infected cells in the blood. These results indicate that varicella zoster virus infection in immunocompetent children is disseminated by circulating T and B lymphocytes and the severity of the viremia is reflected in the severity of the disease.

Original languageEnglish
Pages (from-to)1095-1098
Number of pages4
JournalJournal of Infectious Diseases
Volume161
Issue number6
DOIs
Publication statusPublished - 01-01-1990

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Chickenpox
Viremia
Human Herpesvirus 3
Blood Cells
Lymphocytes
Virus Diseases
Exanthema
Body Temperature
B-Lymphocytes
Fever
Cell Count
Viruses
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Asano, Y., Itakura, N., Kajita, Y., Suga, S., Yoshikawa, T., Yazaki, T., ... Takahashi, M. (1990). Severity of viremia and clinical findings in children with Varicella. Journal of Infectious Diseases, 161(6), 1095-1098. https://doi.org/10.1093/infdis/161.6.1095
Asano, Yoshizo ; Itakura, Naoko ; Kajita, Yuji ; Suga, Sadao ; Yoshikawa, Tetsushi ; Yazaki, Thkehiko ; Ozaki, Thkao ; Yamanishi, Koichi ; Takahashi, Michiaki. / Severity of viremia and clinical findings in children with Varicella. In: Journal of Infectious Diseases. 1990 ; Vol. 161, No. 6. pp. 1095-1098.
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Asano, Y, Itakura, N, Kajita, Y, Suga, S, Yoshikawa, T, Yazaki, T, Ozaki, T, Yamanishi, K & Takahashi, M 1990, 'Severity of viremia and clinical findings in children with Varicella', Journal of Infectious Diseases, vol. 161, no. 6, pp. 1095-1098. https://doi.org/10.1093/infdis/161.6.1095

Severity of viremia and clinical findings in children with Varicella. / Asano, Yoshizo; Itakura, Naoko; Kajita, Yuji; Suga, Sadao; Yoshikawa, Tetsushi; Yazaki, Thkehiko; Ozaki, Thkao; Yamanishi, Koichi; Takahashi, Michiaki.

In: Journal of Infectious Diseases, Vol. 161, No. 6, 01.01.1990, p. 1095-1098.

Research output: Contribution to journalArticle

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AU - Yazaki, Thkehiko

AU - Ozaki, Thkao

AU - Yamanishi, Koichi

AU - Takahashi, Michiaki

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AB - The number of varicella zoster virus-infected mononuclear cells in blood samples obtained during 3 days before appearance of vesicular skin rashes could be estimated in 13 of 21 immunocompetent children with varicella and viremia (range, 1-83 per 107 mononuclear cells). The virus was isolated from 5% of adherent cells (1/21),71% ofnonadherent cells (12/17),43% ofT lymphocytes (9/21), and 33% ofB lymphocytes (7/21). The number of vesicleson the body correlated with the maximum body temperature, duration of fever, and number of infected cells in the blood. These results indicate that varicella zoster virus infection in immunocompetent children is disseminated by circulating T and B lymphocytes and the severity of the viremia is reflected in the severity of the disease.

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