Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice

Atsushi Masuda, Yusuke Seino, Masatoshi Murase, Shihomi Hidaka, Megumi Shibata, Takeshi Takayanagi, Yoshihisa Sugimura, Yoshitaka Hayashi, Atsushi Suzuki

Research output: Contribution to journalArticle

Abstract

Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.

Original languageEnglish
Article number1045
JournalNutrients
Volume11
Issue number5
DOIs
Publication statusPublished - 05-2019

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Protein-Restricted Diet
low protein diet
Starch
Weight Gain
weight gain
Body Weight
starch
body weight
mice
cells
insulin
Insulin
Body Weight Changes
hyperinsulinemia
body weight changes
islets of Langerhans
Hyperinsulinism
chronic exposure
Islets of Langerhans
Diet

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Masuda, Atsushi ; Seino, Yusuke ; Murase, Masatoshi ; Hidaka, Shihomi ; Shibata, Megumi ; Takayanagi, Takeshi ; Sugimura, Yoshihisa ; Hayashi, Yoshitaka ; Suzuki, Atsushi. / Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice. In: Nutrients. 2019 ; Vol. 11, No. 5.
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Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice. / Masuda, Atsushi; Seino, Yusuke; Murase, Masatoshi; Hidaka, Shihomi; Shibata, Megumi; Takayanagi, Takeshi; Sugimura, Yoshihisa; Hayashi, Yoshitaka; Suzuki, Atsushi.

In: Nutrients, Vol. 11, No. 5, 1045, 05.2019.

Research output: Contribution to journalArticle

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AU - Masuda, Atsushi

AU - Seino, Yusuke

AU - Murase, Masatoshi

AU - Hidaka, Shihomi

AU - Shibata, Megumi

AU - Takayanagi, Takeshi

AU - Sugimura, Yoshihisa

AU - Hayashi, Yoshitaka

AU - Suzuki, Atsushi

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