Abstract
Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.
| Original language | English |
|---|---|
| Article number | 1045 |
| Journal | Nutrients |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 05-2019 |
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All Science Journal Classification (ASJC) codes
- Food Science
- Nutrition and Dietetics
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Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice. / Masuda, Atsushi; Seino, Yusuke; Murase, Masatoshi; Hidaka, Shihomi; Shibata, Megumi; Takayanagi, Takeshi; Sugimura, Yoshihisa; Hayashi, Yoshitaka; Suzuki, Atsushi.
In: Nutrients, Vol. 11, No. 5, 1045, 05.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice
AU - Masuda, Atsushi
AU - Seino, Yusuke
AU - Murase, Masatoshi
AU - Hidaka, Shihomi
AU - Shibata, Megumi
AU - Takayanagi, Takeshi
AU - Sugimura, Yoshihisa
AU - Hayashi, Yoshitaka
AU - Suzuki, Atsushi
PY - 2019/5
Y1 - 2019/5
N2 - Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.
AB - Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.
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UR - http://www.scopus.com/inward/citedby.url?scp=85066060830&partnerID=8YFLogxK
U2 - 10.3390/nu11051045
DO - 10.3390/nu11051045
M3 - Article
C2 - 31083314
AN - SCOPUS:85066060830
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 1045
ER -