TY - JOUR
T1 - Short-term high-starch, low-protein diet induces reversible increase in β-cell mass independent of body weight gain in mice
AU - Masuda, Atsushi
AU - Seino, Yusuke
AU - Murase, Masatoshi
AU - Hidaka, Shihomi
AU - Shibata, Megumi
AU - Takayanagi, Takeshi
AU - Sugimura, Yoshihisa
AU - Hayashi, Yoshitaka
AU - Suzuki, Atsushi
N1 - Funding Information:
Funding: This study was supported by grants from Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science to Y.S. (Yusuke Seino). (17k09823) and research grants from Novo Nordisk Pharma Ltd., MSD K.K., Pfizer., Mitsubishi Tanabe Pharma., Eli Lilly and Company., Novartis Pharma., and Daiichi Sankyo Company Ltd.
Funding Information:
This study was supported by grants from Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science to Y.S. (Yusuke Seino). (17k09823) and research grants from Novo Nordisk Pharma Ltd., MSD K.K., Pfizer., Mitsubishi Tanabe Pharma., Eli Lilly and Company., Novartis Pharma., and Daiichi Sankyo Company Ltd. The authors thank Mika Maejima (Fujita Health University) for technical assistance and Nagoya University stuff for technical assistance and suggestions.
PY - 2019/5
Y1 - 2019/5
N2 - Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.
AB - Long-term exposure to a high starch, low-protein diet (HSTD) induces body weight gain and hyperinsulinemia concomitantly with an increase in β-cell mass (BCM) and pancreatic islets number in mice; however, the effect of short-term exposure to HSTD on BCM and islet number has not been elucidated. In the present study, we investigated changes in body weight, plasma insulin levels, BCM and islet number in mice fed HSTD for 5 weeks followed by normal chow (NC) for 2 weeks. BCM and islet number were increased in mice fed HSTD for 5 weeks compared with those in mice fed NC. On the other hand, mice fed HSTD for 5 weeks followed by NC for 2 weeks (SN) showed decreased BCM and insulin levels, compared to mice fed HSTD for 7 weeks, and no significant differences in these parameters were observed between SN and the control NC at 7 weeks. No significant difference in body weight was observed among HSTD, NC and SN fed groups. These results suggest that a high-starch diet induces an increase in BCM in a manner independent of body weight gain, and that 2 weeks of NC feeding is sufficient for the reversal of the morphological changes induced in islets by HSTD feeding.
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U2 - 10.3390/nu11051045
DO - 10.3390/nu11051045
M3 - Article
C2 - 31083314
AN - SCOPUS:85066060830
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 1045
ER -