Significance of birth in the maintenance of quiescent neural stem cells

Koya Kawase; Yasuhisa Nakamura; Laura Wolbeck; Shoko Takemura; Kei Zaitsu; Takehiro Ando; Hideo Jinnou; Masato Sawada; Chikako Nakajima; Rasmus Rydbirk; Sakura Gokenya; Akira Ito; Hitomi Fujiyama; Akari Saito; Akira Iguchi; Panagiotis Kratimenos; Nobuyuki Ishibashi; Vittorio Gallo; Osuke Iwata; Shinji Saitoh; Konstantin Khodosevich; Kazunobu Sawamoto

doi:10.1126/sciadv.adn6377

Significance of birth in the maintenance of quiescent neural stem cells

Koya Kawase
, Yasuhisa Nakamura
, Laura Wolbeck
, Shoko Takemura
, Kei Zaitsu
, Takehiro Ando
, Hideo Jinnou
, Masato Sawada
, Chikako Nakajima
, Rasmus Rydbirk
, Sakura Gokenya
, Akira Ito
, Hitomi Fujiyama
, Akari Saito
, Akira Iguchi
, Panagiotis Kratimenos
, Nobuyuki Ishibashi
, Vittorio Gallo
, Osuke Iwata
, Shinji Saitoh

Konstantin Khodosevich, Kazunobu Sawamoto

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs.

Original language	English
Article number	eadn6377
Journal	Science advances
Volume	11
Issue number	4
DOIs	https://doi.org/10.1126/sciadv.adn6377
Publication status	Published - 24-01-2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

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10.1126/sciadv.adn6377

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Kawase, K., Nakamura, Y., Wolbeck, L., Takemura, S., Zaitsu, K., Ando, T., Jinnou, H., Sawada, M., Nakajima, C., Rydbirk, R., Gokenya, S., Ito, A., Fujiyama, H., Saito, A., Iguchi, A., Kratimenos, P., Ishibashi, N., Gallo, V., Iwata, O., ... Sawamoto, K. (2025). Significance of birth in the maintenance of quiescent neural stem cells. Science advances, 11(4), Article eadn6377. https://doi.org/10.1126/sciadv.adn6377

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title = "Significance of birth in the maintenance of quiescent neural stem cells",

abstract = "Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs.",

author = "Koya Kawase and Yasuhisa Nakamura and Laura Wolbeck and Shoko Takemura and Kei Zaitsu and Takehiro Ando and Hideo Jinnou and Masato Sawada and Chikako Nakajima and Rasmus Rydbirk and Sakura Gokenya and Akira Ito and Hitomi Fujiyama and Akari Saito and Akira Iguchi and Panagiotis Kratimenos and Nobuyuki Ishibashi and Vittorio Gallo and Osuke Iwata and Shinji Saitoh and Konstantin Khodosevich and Kazunobu Sawamoto",

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doi = "10.1126/sciadv.adn6377",

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Kawase, K, Nakamura, Y, Wolbeck, L, Takemura, S, Zaitsu, K, Ando, T, Jinnou, H, Sawada, M, Nakajima, C, Rydbirk, R, Gokenya, S, Ito, A, Fujiyama, H, Saito, A, Iguchi, A, Kratimenos, P, Ishibashi, N, Gallo, V, Iwata, O, Saitoh, S, Khodosevich, K & Sawamoto, K 2025, 'Significance of birth in the maintenance of quiescent neural stem cells', Science advances, vol. 11, no. 4, eadn6377. https://doi.org/10.1126/sciadv.adn6377

TY - JOUR

T1 - Significance of birth in the maintenance of quiescent neural stem cells

AU - Kawase, Koya

AU - Nakamura, Yasuhisa

AU - Wolbeck, Laura

AU - Takemura, Shoko

AU - Zaitsu, Kei

AU - Ando, Takehiro

AU - Jinnou, Hideo

AU - Sawada, Masato

AU - Nakajima, Chikako

AU - Rydbirk, Rasmus

AU - Gokenya, Sakura

AU - Ito, Akira

AU - Fujiyama, Hitomi

AU - Saito, Akari

AU - Iguchi, Akira

AU - Kratimenos, Panagiotis

AU - Ishibashi, Nobuyuki

AU - Gallo, Vittorio

AU - Iwata, Osuke

AU - Saitoh, Shinji

AU - Khodosevich, Konstantin

AU - Sawamoto, Kazunobu

PY - 2025/1/24

Y1 - 2025/1/24

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AB - Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs.

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VL - 11

JO - Science advances

JF - Science advances

IS - 4

M1 - eadn6377

ER -

Significance of birth in the maintenance of quiescent neural stem cells

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