Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury

Tomohiro Mizuno, Waichi Sato, Kazuhiro Ishikawa, Yuki Terao, Kazuo Takahashi, Yukihiro Noda, Yukio Yuzawa, Tadashi Nagamatsu

Research output: Contribution to journalArticle

Abstract

Background/aim: To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. Materials and methods: To detect changing expression of MATE1/SLC47A1 in dose- and time-dependent manners, human proximal tubular epithelial cells were incubated with AGE-aggregated-human serum albumin. As a function assay for MATE1/SLC47A1, human proximal tubular epithelial cells were incubated with cisplatin or carboplatin. Results: On incubation with AGEs, the expressions of MATE1/SLC47A1 were decreased in tubular cells. In addition, the toxicities of cisplatin were increased in tubular cells that had been pretreated with AGEs. However, the toxicities of carboplatin were smaller than that of cisplatin in proximal tubular epithelial cells. Conclusion: The expression of the MATE1/SLC47A1 is decreased by AGEs, which increases the risk for proximal tubular injury.

Original languageEnglish
Article numberA198
Pages (from-to)1701-1706
Number of pages6
JournalOncoTargets and Therapy
Volume8
DOIs
Publication statusPublished - 10-07-2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury'. Together they form a unique fingerprint.

  • Cite this