Significance of human herpesviruses to transplant recipients.

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Despite recent great advances in transplantation techniques, herpesvirus infections remain a major cause of morbidity and mortality in transplant recipients. While improvement in immunosuppressive drug regimens have decreased the risk of graft-versus-host disease and rejection in bone marrow transplant recipients and solid organ transplant recipients, all such drugs carry with them an increased risk of herpesvirus reactivation. The following review consolidates recent findings in this field, covering reports published from January 2002 to August 2003. RECENT FINDINGS: Real-time polymerase chain reaction has improved the ability to distinguish between latent and active herpesvirus infection, which had been a major difficulty in the diagnosis of such conditions. It has been suggested that evaluation of virus-specific cytotoxic T lymphocyte activity is important for prediction of viral diseases. Development of new antiviral drugs has provided other therapeutic options. However, neither prophylactic nor preemptive administration of antiviral drugs can completely abolish the risk of herpesvirus infection. Transfusion of virus-specific cytotoxic T lymphocytes has been suggested to be a useful treatment for recipients with continuous viral replication due to severe immunosuppression. SUMMARY: Recent progress has been made in learning more about the role of virus-specific cytotoxic T lymphocytes, and developing better diagnostic procedures and therapeutic protocols that are efficient and have reduced adverse side effects. Reliable monitoring methods for viral load, in combination with evaluation of virus-specific cytotoxic T cells, has made possible the prediction of viral diseases and furthered understanding of the role of these cells in controlling viral infections. Furthermore, adoptive immunotherapy has been improved by analyzing host immune responses.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalCurrent Opinion in Infectious Diseases
Volume16
Issue number6
DOIs
Publication statusPublished - 01-01-2003

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Herpesviridae
Herpesviridae Infections
Cytotoxic T-Lymphocytes
Virus Diseases
Viruses
Antiviral Agents
Adoptive Immunotherapy
Aptitude
Graft vs Host Disease
Immunosuppressive Agents
Viral Load
Pharmaceutical Preparations
Immunosuppression
Real-Time Polymerase Chain Reaction
Therapeutics
Transplantation
Bone Marrow
Learning
Morbidity
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Significance of human herpesviruses to transplant recipients.",
abstract = "PURPOSE OF REVIEW: Despite recent great advances in transplantation techniques, herpesvirus infections remain a major cause of morbidity and mortality in transplant recipients. While improvement in immunosuppressive drug regimens have decreased the risk of graft-versus-host disease and rejection in bone marrow transplant recipients and solid organ transplant recipients, all such drugs carry with them an increased risk of herpesvirus reactivation. The following review consolidates recent findings in this field, covering reports published from January 2002 to August 2003. RECENT FINDINGS: Real-time polymerase chain reaction has improved the ability to distinguish between latent and active herpesvirus infection, which had been a major difficulty in the diagnosis of such conditions. It has been suggested that evaluation of virus-specific cytotoxic T lymphocyte activity is important for prediction of viral diseases. Development of new antiviral drugs has provided other therapeutic options. However, neither prophylactic nor preemptive administration of antiviral drugs can completely abolish the risk of herpesvirus infection. Transfusion of virus-specific cytotoxic T lymphocytes has been suggested to be a useful treatment for recipients with continuous viral replication due to severe immunosuppression. SUMMARY: Recent progress has been made in learning more about the role of virus-specific cytotoxic T lymphocytes, and developing better diagnostic procedures and therapeutic protocols that are efficient and have reduced adverse side effects. Reliable monitoring methods for viral load, in combination with evaluation of virus-specific cytotoxic T cells, has made possible the prediction of viral diseases and furthered understanding of the role of these cells in controlling viral infections. Furthermore, adoptive immunotherapy has been improved by analyzing host immune responses.",
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Significance of human herpesviruses to transplant recipients. / Yoshikawa, Tetsushi.

In: Current Opinion in Infectious Diseases, Vol. 16, No. 6, 01.01.2003, p. 601-606.

Research output: Contribution to journalReview article

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