Significance of serum magnesium as an independent correlative factor on the parathyroid hormone level in uremic patients

Masaki Ohya, Shigeo Negi, Toshifumi Sakaguchi, Fumihiko Koiwa, Ryoichi Ando, Yasuhiro Komatsu, Toshio Shinoda, Daijo Inaguma, Nobuhiko Joki, Toshihiko Yamaka, Masato Ikeda, Takashi Shigematsu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Context: PTH is a critical factor in mineral homeostasis, and chronic kidney disease mineral and bone metabolism disorder is a very important problem in patients with renal failure. Abnormal levels of PTH, serum phosphate, and calcium influence chronic kidney disease mineral and bone metabolism disorder, but there is little information about the influence of magnesium (Mg) on PTH.

Objective: The aim of this study was to elucidate the correlation between magnesium and PTH levels in uremic patients just prior to beginning hemodialysis (HD) for the first time.

Patients: We enrolled 1231 patients in nine Japanese facilities who had begun HD for end-stage renal disease. We investigated their serum Mg levels and the correlation between intact PTH (iPTH) and the serum Mg levels and other clinical parameters and medications.

Results: The mean serum Mg was 2.2 ±0.5 mg/dL, and hypermagnesemia was found in 663 patients (53.9%). Divided into two groups according to median iPTH level, the serum Mg levels were significantly higher in patients with low iPTH (2.3 ± 0.5 vs 2.1 ± 0.5, P <.01). Furthermore, divided into two groups according to the Mg level, iPTH levels were lower in patients with high Mg than in patients with normal serum Mg levels (277.9 ± 195.9 pg/mL vs 321.9 ± 203.7 pg/mL, P <.01). In the multiple regression analysis according to the effect of iPTH level, the serum Mg level was an independent variable after adjustment for other factors.

Conclusions: A high serum level of Mg is frequent in uremic patients with end-stage renal disease just prior to beginning HD. In the present set of patients, there was a significant correlation between the serum Mg and iPTH levels. Furthermore, the serum Mg level was an independent factor apart from the other factors regulating iPTH. These results suggest that serum Mg may be one of the factors regulating the serum PTH level in uremic patients.

Original languageEnglish
Pages (from-to)3873-3878
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number10
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Ohya, M., Negi, S., Sakaguchi, T., Koiwa, F., Ando, R., Komatsu, Y., Shinoda, T., Inaguma, D., Joki, N., Yamaka, T., Ikeda, M., & Shigematsu, T. (2014). Significance of serum magnesium as an independent correlative factor on the parathyroid hormone level in uremic patients. Journal of Clinical Endocrinology and Metabolism, 99(10), 3873-3878. https://doi.org/10.1210/jc.2013-4396