Significance of 18 F-Fluorodeoxyglucose (FDG) Uptake in Response to Chemoradiotherapy for Pancreatic Cancer

Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Takaaki Arigami, Shinichiro Mori, Yuko Kijima, Shinichi Ueno, Hiroyuki Shinchi, Shoji Natsugoe

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: A metabolic shift to glycolysis is reportedly involved in radioresistance. We examined whether pretreatment 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET), which can detect enhanced glucose uptake, was able to predict the therapeutic response to chemoradiotherapy (CRT) in patients with pancreatic cancer (PC). Methods: Of 125 PC patients (75 unresectable and 50 borderline resectable), 37 and 26 underwent induction chemotherapy before CRT and surgical resection after CRT, respectively. FDG-PET was performed at three different institutions. Results: Of the 88 patients who underwent upfront CRT, 31 (35%), 34 (39%), and 23 (26%) showed a partial response (PR), stable disease, and progressive disease, respectively. The tumor PR rate was an independent factor associated with longer overall survival (OS) on multivariate analysis. We evaluated the optimal cut-off of maximum standardized uptake values (SUV max ) at initial diagnosis to detect the tumor PR rate at the three institutions separately. The SUV max was independently associated with tumor response rate on multivariate analysis. In the low SUV max group, induction chemotherapy had no significant impact on OS. In contrast, induction chemotherapy was significantly associated with longer OS in the high SUV max group. Conclusions: FDG-PET SUV max was significantly associated with the therapeutic response to CRT in PC patients. Moreover, induction chemotherapy may improve the prognosis of patients with a high SUV max tumor.

Original languageEnglish
Pages (from-to)644-651
Number of pages8
JournalAnnals of Surgical Oncology
Issue number2
Publication statusPublished - 15-02-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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