Significant association between Helicobacter pylori infection and serum C-reactive protein

Yoshiko Ishida, Koji Suzuki, Kentaro Taki, Toshimitsu Niwa, Shozo Kurotsuchi, Hisao Ando, Akira Iwase, Kazuko Nishio, Kenji Wakai, Yoshinori Ito, Nobuyuki Hamajima

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test. Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model. Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalInternational Journal of Medical Sciences
Volume5
Issue number4
DOIs
Publication statusPublished - 24-07-2008

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Helicobacter Infections
Helicobacter pylori
C-Reactive Protein
Blood Proteins
Serum
Odds Ratio
Female Infertility
Health
Gastric Mucosa
Infertility
Japan
Body Mass Index
Immunoglobulin G
Logistic Models
Smoking
Confidence Intervals
Antibodies
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ishida, Yoshiko ; Suzuki, Koji ; Taki, Kentaro ; Niwa, Toshimitsu ; Kurotsuchi, Shozo ; Ando, Hisao ; Iwase, Akira ; Nishio, Kazuko ; Wakai, Kenji ; Ito, Yoshinori ; Hamajima, Nobuyuki. / Significant association between Helicobacter pylori infection and serum C-reactive protein. In: International Journal of Medical Sciences. 2008 ; Vol. 5, No. 4. pp. 224-229.
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abstract = "Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test. Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3{\%} and 20.1{\%} in YTI, 22.0{\%} and 16.0{\%} in ENUH, and 32.7{\%} and 18.7{\%} in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95{\%} confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model. Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.",
author = "Yoshiko Ishida and Koji Suzuki and Kentaro Taki and Toshimitsu Niwa and Shozo Kurotsuchi and Hisao Ando and Akira Iwase and Kazuko Nishio and Kenji Wakai and Yoshinori Ito and Nobuyuki Hamajima",
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Ishida, Y, Suzuki, K, Taki, K, Niwa, T, Kurotsuchi, S, Ando, H, Iwase, A, Nishio, K, Wakai, K, Ito, Y & Hamajima, N 2008, 'Significant association between Helicobacter pylori infection and serum C-reactive protein', International Journal of Medical Sciences, vol. 5, no. 4, pp. 224-229. https://doi.org/10.7150/ijms.5.224

Significant association between Helicobacter pylori infection and serum C-reactive protein. / Ishida, Yoshiko; Suzuki, Koji; Taki, Kentaro; Niwa, Toshimitsu; Kurotsuchi, Shozo; Ando, Hisao; Iwase, Akira; Nishio, Kazuko; Wakai, Kenji; Ito, Yoshinori; Hamajima, Nobuyuki.

In: International Journal of Medical Sciences, Vol. 5, No. 4, 24.07.2008, p. 224-229.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Significant association between Helicobacter pylori infection and serum C-reactive protein

AU - Ishida, Yoshiko

AU - Suzuki, Koji

AU - Taki, Kentaro

AU - Niwa, Toshimitsu

AU - Kurotsuchi, Shozo

AU - Ando, Hisao

AU - Iwase, Akira

AU - Nishio, Kazuko

AU - Wakai, Kenji

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

PY - 2008/7/24

Y1 - 2008/7/24

N2 - Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test. Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model. Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

AB - Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP). Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test. Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model. Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

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