Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study

Asahi Hishida, Kenji Wakai, Rieko Okada, Emi Morita, Nobuyuki Hamajima, Satoyo Hosono, Yasuki Higaki, Tanvir Chowdhury Turin, Sadao Suzuki, Kheradm Motahareh, Haruo Mikami, Naotaka Tashiro, Isao Watanabe, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Mariko Naito

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Abstract

We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non- DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI < 25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalEndocrine Journal
Volume60
Issue number2
DOIs
Publication statusPublished - 11-03-2013

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Resistin
Type 2 Diabetes Mellitus
Diabetes Mellitus
Genotype
Life Style
Logistic Models
Informed Consent
Sample Size
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Hishida, Asahi ; Wakai, Kenji ; Okada, Rieko ; Morita, Emi ; Hamajima, Nobuyuki ; Hosono, Satoyo ; Higaki, Yasuki ; Turin, Tanvir Chowdhury ; Suzuki, Sadao ; Motahareh, Kheradm ; Mikami, Haruo ; Tashiro, Naotaka ; Watanabe, Isao ; Katsuura, Sakurako ; Kubo, Michiaki ; Tanaka, Hideo ; Naito, Mariko. / Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study. In: Endocrine Journal. 2013 ; Vol. 60, No. 2. pp. 237-243.
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title = "Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study",
abstract = "We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non- DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI < 25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95{\%} confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.",
author = "Asahi Hishida and Kenji Wakai and Rieko Okada and Emi Morita and Nobuyuki Hamajima and Satoyo Hosono and Yasuki Higaki and Turin, {Tanvir Chowdhury} and Sadao Suzuki and Kheradm Motahareh and Haruo Mikami and Naotaka Tashiro and Isao Watanabe and Sakurako Katsuura and Michiaki Kubo and Hideo Tanaka and Mariko Naito",
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Hishida, A, Wakai, K, Okada, R, Morita, E, Hamajima, N, Hosono, S, Higaki, Y, Turin, TC, Suzuki, S, Motahareh, K, Mikami, H, Tashiro, N, Watanabe, I, Katsuura, S, Kubo, M, Tanaka, H & Naito, M 2013, 'Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study', Endocrine Journal, vol. 60, no. 2, pp. 237-243. https://doi.org/10.1507/endocrj.EJ12-0307

Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study. / Hishida, Asahi; Wakai, Kenji; Okada, Rieko; Morita, Emi; Hamajima, Nobuyuki; Hosono, Satoyo; Higaki, Yasuki; Turin, Tanvir Chowdhury; Suzuki, Sadao; Motahareh, Kheradm; Mikami, Haruo; Tashiro, Naotaka; Watanabe, Isao; Katsuura, Sakurako; Kubo, Michiaki; Tanaka, Hideo; Naito, Mariko.

In: Endocrine Journal, Vol. 60, No. 2, 11.03.2013, p. 237-243.

Research output: Contribution to journalArticle

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T1 - Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study

AU - Hishida, Asahi

AU - Wakai, Kenji

AU - Okada, Rieko

AU - Morita, Emi

AU - Hamajima, Nobuyuki

AU - Hosono, Satoyo

AU - Higaki, Yasuki

AU - Turin, Tanvir Chowdhury

AU - Suzuki, Sadao

AU - Motahareh, Kheradm

AU - Mikami, Haruo

AU - Tashiro, Naotaka

AU - Watanabe, Isao

AU - Katsuura, Sakurako

AU - Kubo, Michiaki

AU - Tanaka, Hideo

AU - Naito, Mariko

PY - 2013/3/11

Y1 - 2013/3/11

N2 - We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non- DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI < 25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.

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