Silencing of STRN4 suppresses the malignant characteristics of cancer cells

Meihong Wong, Toshinori Hyodo, Eri Asano, Kohei Funasaka, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto, Michinari Hamaguchi, Takeshi Senga

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN4 is associated with tumor progression. In this report, we examined the role that STRN4 plays in cancer malignancy. We show that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells. In addition, STRN4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN4 in tumor progression. STRN4 is a multidomain-structured proteins that associate with numerous proteins to form a large protein complex. We show that STRN4 is associated with malignant characteristics of cancer cells.

Original languageEnglish
Pages (from-to)1526-1532
Number of pages7
JournalCancer science
Volume105
Issue number12
DOIs
Publication statusPublished - 01-12-2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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