TY - JOUR
T1 - Silencing of STRN4 suppresses the malignant characteristics of cancer cells
AU - Wong, Meihong
AU - Hyodo, Toshinori
AU - Asano, Eri
AU - Funasaka, Kohei
AU - Miyahara, Ryoji
AU - Hirooka, Yoshiki
AU - Goto, Hidemi
AU - Hamaguchi, Michinari
AU - Senga, Takeshi
N1 - Publisher Copyright:
© 2014 The Authors.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN4 is associated with tumor progression. In this report, we examined the role that STRN4 plays in cancer malignancy. We show that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells. In addition, STRN4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN4 in tumor progression. STRN4 is a multidomain-structured proteins that associate with numerous proteins to form a large protein complex. We show that STRN4 is associated with malignant characteristics of cancer cells.
AB - The striatin family of proteins, comprising STRN, STRN3 and STRN4, are multidomain-containing proteins that associate with additional proteins to form a large protein complex. We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression. However, it remains unclear whether STRN4 is associated with tumor progression. In this report, we examined the role that STRN4 plays in cancer malignancy. We show that depletion of STRN4 suppresses proliferation, migration, invasion and the anchorage-independent growth of cancer cells. In addition, STRN4 knockdown increases the sensitivity of pancreatic cancer cells to gemcitabine. Finally, we show that STRN4 knockdown suppresses the proliferation and metastasis of cancer cells in mice. Our results demonstrate a possible role of STRN4 in tumor progression. STRN4 is a multidomain-structured proteins that associate with numerous proteins to form a large protein complex. We show that STRN4 is associated with malignant characteristics of cancer cells.
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U2 - 10.1111/cas.12541
DO - 10.1111/cas.12541
M3 - Article
C2 - 25250919
AN - SCOPUS:84917743194
SN - 1347-9032
VL - 105
SP - 1526
EP - 1532
JO - Cancer science
JF - Cancer science
IS - 12
ER -