TY - JOUR
T1 - Simultaneous determination of amino-α-carbolines and amino-γ-carbolines in cigarette smoke condensate by high-performance liquid chromatography
AU - Manabe, Shigeo
AU - Wada, Osamu
AU - Kanai, Yoshikatsu
PY - 1990
Y1 - 1990
N2 - A method for the simultaneous detection of amino-α-carbolines (2-amino-α-carboline and 2-amino-3-methyl-α-carboline) and amino-γ-carbolines (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole) by high-performance liquid chromatography has been developed. It consists of a three-step purification using three different columns with fluorometric detection. With this method, we have demonstrated that both amino-α-carbolines and amino-γ-carbolines are present in cigarette smoke condensate. The method may be useful for detecting these carcinogens in various materials.
AB - A method for the simultaneous detection of amino-α-carbolines (2-amino-α-carboline and 2-amino-3-methyl-α-carboline) and amino-γ-carbolines (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole) by high-performance liquid chromatography has been developed. It consists of a three-step purification using three different columns with fluorometric detection. With this method, we have demonstrated that both amino-α-carbolines and amino-γ-carbolines are present in cigarette smoke condensate. The method may be useful for detecting these carcinogens in various materials.
UR - https://www.scopus.com/pages/publications/0025295126
UR - https://www.scopus.com/pages/publications/0025295126#tab=citedBy
U2 - 10.1016/S0378-4347(00)83813-X
DO - 10.1016/S0378-4347(00)83813-X
M3 - Article
C2 - 2211925
AN - SCOPUS:0025295126
SN - 0378-4347
VL - 529
SP - 125
EP - 133
JO - Journal of Chromatography B: Biomedical Sciences and Applications
JF - Journal of Chromatography B: Biomedical Sciences and Applications
IS - C
ER -