TY - JOUR
T1 - Single-dose rituximab therapy for refractory idiopathic membranous nephropathy
T2 - A single-center experience
AU - Katsuno, Takayuki
AU - Ozaki, Takenori
AU - Kim, Hangsoo
AU - Kato, Noritoshi
AU - Suzuki, Yasuhiro
AU - Akiyama, Shinichi
AU - Ishimoto, Takuji
AU - Kosugi, Tomoki
AU - Tsuboi, Naotake
AU - Ito, Yasuhiko
AU - Maruyama, Shoichi
N1 - Publisher Copyright:
© 2017 The Japanese Society of Internal Medicine.
PY - 2017
Y1 - 2017
N2 - To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil. Although one case showed no response, a complete or incomplete remission was achieved in the other two cases. Rituximab may therefore be a beneficial treatment option for IMN.
AB - To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil. Although one case showed no response, a complete or incomplete remission was achieved in the other two cases. Rituximab may therefore be a beneficial treatment option for IMN.
KW - Membranous nephropathy
KW - Nephrotic syndrome
KW - Rituximab
UR - https://www.scopus.com/pages/publications/85021752469
UR - https://www.scopus.com/pages/publications/85021752469#tab=citedBy
U2 - 10.2169/internalmedicine.56.7908
DO - 10.2169/internalmedicine.56.7908
M3 - Article
C2 - 28674357
AN - SCOPUS:85021752469
SN - 0918-2918
VL - 56
SP - 1679
EP - 1686
JO - Internal Medicine
JF - Internal Medicine
IS - 13
ER -