Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan

Hisashi Oishi, Tatsuaki Watanabe, Yasushi Matsuda, Masafumi Noda, Yutaka Ejima, Yoshikatsu Saiki, Kuniaki Seyama, Takashi Kondo, Yoshinori Okada

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Purpose: Lung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleiomyomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan. Methods: We reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, complications, morbidity, mortality and survival after SLT for LAM. Results: The most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second-most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%. Conclusion: LAM-related complications after SLT for this disease can be managed. SLT is a treatment option and may improve access to lung transplantation for patients with end-stage LAM.

Original languageEnglish
Pages (from-to)944-950
Number of pages7
JournalSurgery Today
Issue number10
Publication statusPublished - 01-10-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery


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