Single-walled carbon nanohorns as drug carriers: Adsorption of prednisolone and anti-inflammatory effects on arthritis

Maki Nakamura, Yoshio Tahara, Yuzuru Ikehara, Tatsuya Murakami, Kunihiro Tsuchida, Sumio Iijima, Iwao Waga, Masako Yudasaka

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30 Citations (Scopus)

Abstract

Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.

Original languageEnglish
Article number465102
JournalNanotechnology
Volume22
Issue number46
DOIs
Publication statusPublished - 18-11-2011

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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