TY - JOUR
T1 - Single-walled carbon nanohorns as drug carriers
T2 - Adsorption of prednisolone and anti-inflammatory effects on arthritis
AU - Nakamura, Maki
AU - Tahara, Yoshio
AU - Ikehara, Yuzuru
AU - Murakami, Tatsuya
AU - Tsuchida, Kunihiro
AU - Iijima, Sumio
AU - Waga, Iwao
AU - Yudasaka, Masako
PY - 2011/11/18
Y1 - 2011/11/18
N2 - Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
AB - Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
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U2 - 10.1088/0957-4484/22/46/465102
DO - 10.1088/0957-4484/22/46/465102
M3 - Article
C2 - 22024636
AN - SCOPUS:80155186975
SN - 0957-4484
VL - 22
JO - Nanotechnology
JF - Nanotechnology
IS - 46
M1 - 465102
ER -