Abstract
Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
| Original language | English |
|---|---|
| Article number | 465102 |
| Journal | Nanotechnology |
| Volume | 22 |
| Issue number | 46 |
| DOIs | |
| Publication status | Published - 18-11-2011 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Chemistry(all)
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
- Electrical and Electronic Engineering
Cite this
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Single-walled carbon nanohorns as drug carriers : Adsorption of prednisolone and anti-inflammatory effects on arthritis. / Nakamura, Maki; Tahara, Yoshio; Ikehara, Yuzuru; Murakami, Tatsuya; Tsuchida, Kunihiro; Iijima, Sumio; Waga, Iwao; Yudasaka, Masako.
In: Nanotechnology, Vol. 22, No. 46, 465102, 18.11.2011.Research output: Contribution to journal › Article
TY - JOUR
T1 - Single-walled carbon nanohorns as drug carriers
T2 - Adsorption of prednisolone and anti-inflammatory effects on arthritis
AU - Nakamura, Maki
AU - Tahara, Yoshio
AU - Ikehara, Yuzuru
AU - Murakami, Tatsuya
AU - Tsuchida, Kunihiro
AU - Iijima, Sumio
AU - Waga, Iwao
AU - Yudasaka, Masako
PY - 2011/11/18
Y1 - 2011/11/18
N2 - Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
AB - Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
UR - http://www.scopus.com/inward/record.url?scp=80155186975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80155186975&partnerID=8YFLogxK
U2 - 10.1088/0957-4484/22/46/465102
DO - 10.1088/0957-4484/22/46/465102
M3 - Article
VL - 22
JO - Nanotechnology
JF - Nanotechnology
SN - 0957-4484
IS - 46
M1 - 465102
ER -