Abstract
Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.
| Original language | English |
|---|---|
| Pages (from-to) | 56-60 |
| Number of pages | 5 |
| Journal | Circulation Journal |
| Volume | 72 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 27-03-2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. / Aoyama, Toru; Ishii, Hideki; Toriyama, Takanobu; Takahashi, Hiroshi; Kasuga, Hirotake; Murakami, Ryuichiro; Amano, Tetsuya; Uetani, Tadayuki; Yasuda, Yoshinari; Yuzawa, Yukio; Maruyama, Shoichi; Matsuo, Seiichi; Matsubara, Tatsuaki; Murohara, Toyoaki.
In: Circulation Journal, Vol. 72, No. 1, 27.03.2008, p. 56-60.Research output: Contribution to journal › Article
TY - JOUR
T1 - Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis
AU - Aoyama, Toru
AU - Ishii, Hideki
AU - Toriyama, Takanobu
AU - Takahashi, Hiroshi
AU - Kasuga, Hirotake
AU - Murakami, Ryuichiro
AU - Amano, Tetsuya
AU - Uetani, Tadayuki
AU - Yasuda, Yoshinari
AU - Yuzawa, Yukio
AU - Maruyama, Shoichi
AU - Matsuo, Seiichi
AU - Matsubara, Tatsuaki
AU - Murohara, Toyoaki
PY - 2008/3/27
Y1 - 2008/3/27
N2 - Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.
AB - Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.
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U2 - 10.1253/circj.72.56
DO - 10.1253/circj.72.56
M3 - Article
VL - 72
SP - 56
EP - 60
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 1
ER -