Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis

Toru Aoyama, Hideki Ishii, Takanobu Toriyama, Hiroshi Takahashi, Hirotake Kasuga, Ryuichiro Murakami, Tetsuya Amano, Tadayuki Uetani, Yoshinari Yasuda, Yukio Yuzawa, Shoichi Maruyama, Seiichi Matsuo, Tatsuaki Matsubara, Toyoaki Murohara

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Abstract

Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalCirculation Journal
Volume72
Issue number1
DOIs
Publication statusPublished - 27-03-2008

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Sirolimus
Stents
Renal Insufficiency
Renal Dialysis
Metals
Percutaneous Coronary Intervention
Confidence Intervals
Hyperlipidemias
Chronic Kidney Failure
Survivors
Atherosclerosis
Pathologic Constriction
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Aoyama, T., Ishii, H., Toriyama, T., Takahashi, H., Kasuga, H., Murakami, R., ... Murohara, T. (2008). Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. Circulation Journal, 72(1), 56-60. https://doi.org/10.1253/circj.72.56
Aoyama, Toru ; Ishii, Hideki ; Toriyama, Takanobu ; Takahashi, Hiroshi ; Kasuga, Hirotake ; Murakami, Ryuichiro ; Amano, Tetsuya ; Uetani, Tadayuki ; Yasuda, Yoshinari ; Yuzawa, Yukio ; Maruyama, Shoichi ; Matsuo, Seiichi ; Matsubara, Tatsuaki ; Murohara, Toyoaki. / Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. In: Circulation Journal. 2008 ; Vol. 72, No. 1. pp. 56-60.
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abstract = "Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50{\%} diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2{\%} in the SES group and 24.4{\%} in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95{\%} confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95{\%}CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95{\%}CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95{\%}CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.",
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Aoyama, T, Ishii, H, Toriyama, T, Takahashi, H, Kasuga, H, Murakami, R, Amano, T, Uetani, T, Yasuda, Y, Yuzawa, Y, Maruyama, S, Matsuo, S, Matsubara, T & Murohara, T 2008, 'Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis', Circulation Journal, vol. 72, no. 1, pp. 56-60. https://doi.org/10.1253/circj.72.56

Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. / Aoyama, Toru; Ishii, Hideki; Toriyama, Takanobu; Takahashi, Hiroshi; Kasuga, Hirotake; Murakami, Ryuichiro; Amano, Tetsuya; Uetani, Tadayuki; Yasuda, Yoshinari; Yuzawa, Yukio; Maruyama, Shoichi; Matsuo, Seiichi; Matsubara, Tatsuaki; Murohara, Toyoaki.

In: Circulation Journal, Vol. 72, No. 1, 27.03.2008, p. 56-60.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis

AU - Aoyama, Toru

AU - Ishii, Hideki

AU - Toriyama, Takanobu

AU - Takahashi, Hiroshi

AU - Kasuga, Hirotake

AU - Murakami, Ryuichiro

AU - Amano, Tetsuya

AU - Uetani, Tadayuki

AU - Yasuda, Yoshinari

AU - Yuzawa, Yukio

AU - Maruyama, Shoichi

AU - Matsuo, Seiichi

AU - Matsubara, Tatsuaki

AU - Murohara, Toyoaki

PY - 2008/3/27

Y1 - 2008/3/27

N2 - Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.

AB - Background: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. Methods and Results: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as ≥50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). Conclusions: Even if heated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.

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U2 - 10.1253/circj.72.56

DO - 10.1253/circj.72.56

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C2 - 18159100

AN - SCOPUS:39849084996

VL - 72

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JO - Circulation Journal

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