Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese

Yasuhiko Shimoyama, Koji Suzuki, Nobuyuki Hamajima, Toshimitsu Niwa

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Sirtuin 1 (SIRT1) is a longevity gene that protects cells against oxidative and genotoxic stress. This study aimed to investigate the associations of SIRT1 gene single nucleotide polymorphisms (SNPs), rs7895833, rs7069102, and rs2273773, with various laboratory data in 1279 Japanese health checkup examinees. The genotyping was performed using a polymerase chain reaction (PCR) with confronting 2-pair primers (CTPP) assay. Concerning rs7895833 (A allele frequency: 0.290), body fat ratio and body mass index were high in the AA carriers of male subjects, and diastolic blood pressure was high in the AA carriers of female subjects. Concerning rs7069102 (G allele frequency: 0.181), body fat ratio and systolic blood pressure were high in the GG carriers of male subjects. Concerning rs2273773 (C allele frequency: 0.323), fasting glucose and body fat ratio were high in the TT carriers of male subjects, and systolic and diastolic blood pressures were high in the CC carriers of male subjects. Thus, the A allele of rs7895833, G allele of rs7069102, and T allele of rs2273773 carried a high risk for obesity in men. Furthermore, the A allele of rs7895833 in women, and the G allele of rs7069102 and C allele of rs2273773 in men, carried a high risk for hypertension. The T allele of rs2273773 in men carried a high risk for hyperglycemia. In conclusion, these SIRT1 gene polymorphisms are associated with high body fat and blood pressure in Japanese, especially in men. The allele frequencies of rs7895833 and rs7069102, which are different from Caucasians, might explain why Japanese show less marked obesity compared with Caucasians.

Original languageEnglish
Pages (from-to)339-347
Number of pages9
JournalTranslational Research
Volume157
Issue number6
DOIs
Publication statusPublished - 01-01-2011

Fingerprint

Sirtuin 1
Blood pressure
Polymorphism
Adipose Tissue
Genes
Fats
Alleles
Blood Pressure
Gene Frequency
Polymerase chain reaction
Obesity
Assays
Nucleotides
Health
Glucose
Hyperglycemia
DNA Damage
Single Nucleotide Polymorphism
Fasting
Oxidative Stress

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Shimoyama, Yasuhiko ; Suzuki, Koji ; Hamajima, Nobuyuki ; Niwa, Toshimitsu. / Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese. In: Translational Research. 2011 ; Vol. 157, No. 6. pp. 339-347.
@article{64e0044e5ea44bca969be77eb525f4cc,
title = "Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese",
abstract = "Sirtuin 1 (SIRT1) is a longevity gene that protects cells against oxidative and genotoxic stress. This study aimed to investigate the associations of SIRT1 gene single nucleotide polymorphisms (SNPs), rs7895833, rs7069102, and rs2273773, with various laboratory data in 1279 Japanese health checkup examinees. The genotyping was performed using a polymerase chain reaction (PCR) with confronting 2-pair primers (CTPP) assay. Concerning rs7895833 (A allele frequency: 0.290), body fat ratio and body mass index were high in the AA carriers of male subjects, and diastolic blood pressure was high in the AA carriers of female subjects. Concerning rs7069102 (G allele frequency: 0.181), body fat ratio and systolic blood pressure were high in the GG carriers of male subjects. Concerning rs2273773 (C allele frequency: 0.323), fasting glucose and body fat ratio were high in the TT carriers of male subjects, and systolic and diastolic blood pressures were high in the CC carriers of male subjects. Thus, the A allele of rs7895833, G allele of rs7069102, and T allele of rs2273773 carried a high risk for obesity in men. Furthermore, the A allele of rs7895833 in women, and the G allele of rs7069102 and C allele of rs2273773 in men, carried a high risk for hypertension. The T allele of rs2273773 in men carried a high risk for hyperglycemia. In conclusion, these SIRT1 gene polymorphisms are associated with high body fat and blood pressure in Japanese, especially in men. The allele frequencies of rs7895833 and rs7069102, which are different from Caucasians, might explain why Japanese show less marked obesity compared with Caucasians.",
author = "Yasuhiko Shimoyama and Koji Suzuki and Nobuyuki Hamajima and Toshimitsu Niwa",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.trsl.2011.02.004",
language = "English",
volume = "157",
pages = "339--347",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "6",

}

Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese. / Shimoyama, Yasuhiko; Suzuki, Koji; Hamajima, Nobuyuki; Niwa, Toshimitsu.

In: Translational Research, Vol. 157, No. 6, 01.01.2011, p. 339-347.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sirtuin 1 gene polymorphisms are associated with body fat and blood pressure in Japanese

AU - Shimoyama, Yasuhiko

AU - Suzuki, Koji

AU - Hamajima, Nobuyuki

AU - Niwa, Toshimitsu

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Sirtuin 1 (SIRT1) is a longevity gene that protects cells against oxidative and genotoxic stress. This study aimed to investigate the associations of SIRT1 gene single nucleotide polymorphisms (SNPs), rs7895833, rs7069102, and rs2273773, with various laboratory data in 1279 Japanese health checkup examinees. The genotyping was performed using a polymerase chain reaction (PCR) with confronting 2-pair primers (CTPP) assay. Concerning rs7895833 (A allele frequency: 0.290), body fat ratio and body mass index were high in the AA carriers of male subjects, and diastolic blood pressure was high in the AA carriers of female subjects. Concerning rs7069102 (G allele frequency: 0.181), body fat ratio and systolic blood pressure were high in the GG carriers of male subjects. Concerning rs2273773 (C allele frequency: 0.323), fasting glucose and body fat ratio were high in the TT carriers of male subjects, and systolic and diastolic blood pressures were high in the CC carriers of male subjects. Thus, the A allele of rs7895833, G allele of rs7069102, and T allele of rs2273773 carried a high risk for obesity in men. Furthermore, the A allele of rs7895833 in women, and the G allele of rs7069102 and C allele of rs2273773 in men, carried a high risk for hypertension. The T allele of rs2273773 in men carried a high risk for hyperglycemia. In conclusion, these SIRT1 gene polymorphisms are associated with high body fat and blood pressure in Japanese, especially in men. The allele frequencies of rs7895833 and rs7069102, which are different from Caucasians, might explain why Japanese show less marked obesity compared with Caucasians.

AB - Sirtuin 1 (SIRT1) is a longevity gene that protects cells against oxidative and genotoxic stress. This study aimed to investigate the associations of SIRT1 gene single nucleotide polymorphisms (SNPs), rs7895833, rs7069102, and rs2273773, with various laboratory data in 1279 Japanese health checkup examinees. The genotyping was performed using a polymerase chain reaction (PCR) with confronting 2-pair primers (CTPP) assay. Concerning rs7895833 (A allele frequency: 0.290), body fat ratio and body mass index were high in the AA carriers of male subjects, and diastolic blood pressure was high in the AA carriers of female subjects. Concerning rs7069102 (G allele frequency: 0.181), body fat ratio and systolic blood pressure were high in the GG carriers of male subjects. Concerning rs2273773 (C allele frequency: 0.323), fasting glucose and body fat ratio were high in the TT carriers of male subjects, and systolic and diastolic blood pressures were high in the CC carriers of male subjects. Thus, the A allele of rs7895833, G allele of rs7069102, and T allele of rs2273773 carried a high risk for obesity in men. Furthermore, the A allele of rs7895833 in women, and the G allele of rs7069102 and C allele of rs2273773 in men, carried a high risk for hypertension. The T allele of rs2273773 in men carried a high risk for hyperglycemia. In conclusion, these SIRT1 gene polymorphisms are associated with high body fat and blood pressure in Japanese, especially in men. The allele frequencies of rs7895833 and rs7069102, which are different from Caucasians, might explain why Japanese show less marked obesity compared with Caucasians.

UR - http://www.scopus.com/inward/record.url?scp=79956076564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956076564&partnerID=8YFLogxK

U2 - 10.1016/j.trsl.2011.02.004

DO - 10.1016/j.trsl.2011.02.004

M3 - Article

C2 - 21575918

AN - SCOPUS:79956076564

VL - 157

SP - 339

EP - 347

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 6

ER -