Site-specific cancer risk due to diabetes mellitus history: Evidence from the Japan Collaborative Cohort (JACC) study

M. M.H. Khan, Mitsuru Mori, Yoshihisa Fujino, Akira Shibata, Fumio Sakauchi, Masakazu Washio, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Yoshinori Ito, Shuji HashimotoShogo Kikuchi, Kenji Wakai, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Naoyuki Okamoto, Hideo Shio, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95% confidence intervals (95%CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5% of men and 4.6% of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95%CI=1.47-3.59) and women (IRR=2.70; 95%CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95%CI=1.04-7.38) and stomach cancer (IRR=0.67; 95%CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95%CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number2
Publication statusPublished - 01-01-2006

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Diabetes Mellitus
Japan
Cohort Studies
Confidence Intervals
Incidence
Neoplasms
Drinking
Stomach Neoplasms
Body Mass Index
Smoking
Liver Neoplasms
Proportional Hazards Models
Non-Hodgkin's Lymphoma
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Khan, M. M. H., Mori, M., Fujino, Y., Shibata, A., Sakauchi, F., Washio, M., ... Tajima, K. (2006). Site-specific cancer risk due to diabetes mellitus history: Evidence from the Japan Collaborative Cohort (JACC) study. Asian Pacific Journal of Cancer Prevention, 7(2), 253-259.
Khan, M. M.H. ; Mori, Mitsuru ; Fujino, Yoshihisa ; Shibata, Akira ; Sakauchi, Fumio ; Washio, Masakazu ; Tamakoshi, Akiko ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Toyoshima, Hideaki ; Tokudome, Shinkan ; Ito, Yoshinori ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wakai, Kenji ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Okamoto, Naoyuki ; Shio, Hideo ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Site-specific cancer risk due to diabetes mellitus history : Evidence from the Japan Collaborative Cohort (JACC) study. In: Asian Pacific Journal of Cancer Prevention. 2006 ; Vol. 7, No. 2. pp. 253-259.
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abstract = "The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95{\%} confidence intervals (95{\%}CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5{\%} of men and 4.6{\%} of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95{\%}CI=1.47-3.59) and women (IRR=2.70; 95{\%}CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95{\%}CI=1.04-7.38) and stomach cancer (IRR=0.67; 95{\%}CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95{\%}CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.",
author = "Khan, {M. M.H.} and Mitsuru Mori and Yoshihisa Fujino and Akira Shibata and Fumio Sakauchi and Masakazu Washio and Akiko Tamakoshi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Hideaki Toyoshima and Shinkan Tokudome and Yoshinori Ito and Shuji Hashimoto and Shogo Kikuchi and Kenji Wakai and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Naoyuki Okamoto and Hideo Shio and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Khan, MMH, Mori, M, Fujino, Y, Shibata, A, Sakauchi, F, Washio, M, Tamakoshi, A, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Toyoshima, H, Tokudome, S, Ito, Y, Hashimoto, S, Kikuchi, S, Wakai, K, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T & Tajima, K 2006, 'Site-specific cancer risk due to diabetes mellitus history: Evidence from the Japan Collaborative Cohort (JACC) study', Asian Pacific Journal of Cancer Prevention, vol. 7, no. 2, pp. 253-259.

Site-specific cancer risk due to diabetes mellitus history : Evidence from the Japan Collaborative Cohort (JACC) study. / Khan, M. M.H.; Mori, Mitsuru; Fujino, Yoshihisa; Shibata, Akira; Sakauchi, Fumio; Washio, Masakazu; Tamakoshi, Akiko; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Toyoshima, Hideaki; Tokudome, Shinkan; Ito, Yoshinori; Hashimoto, Shuji; Kikuchi, Shogo; Wakai, Kenji; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Okamoto, Naoyuki; Shio, Hideo; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 7, No. 2, 01.01.2006, p. 253-259.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Site-specific cancer risk due to diabetes mellitus history

T2 - Evidence from the Japan Collaborative Cohort (JACC) study

AU - Khan, M. M.H.

AU - Mori, Mitsuru

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Sakauchi, Fumio

AU - Washio, Masakazu

AU - Tamakoshi, Akiko

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Toyoshima, Hideaki

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wakai, Kenji

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95% confidence intervals (95%CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5% of men and 4.6% of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95%CI=1.47-3.59) and women (IRR=2.70; 95%CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95%CI=1.04-7.38) and stomach cancer (IRR=0.67; 95%CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95%CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.

AB - The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95% confidence intervals (95%CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5% of men and 4.6% of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95%CI=1.47-3.59) and women (IRR=2.70; 95%CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95%CI=1.04-7.38) and stomach cancer (IRR=0.67; 95%CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95%CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.

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