TY - JOUR
T1 - Site-specific cancer risk due to diabetes mellitus history
T2 - Evidence from the Japan Collaborative Cohort (JACC) study
AU - Khan, M. M.H.
AU - Mori, Mitsuru
AU - Fujino, Yoshihisa
AU - Shibata, Akira
AU - Sakauchi, Fumio
AU - Washio, Masakazu
AU - Tamakoshi, Akiko
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Iso, Hiroyasu
AU - Mikami, Haruo
AU - Inaba, Yutaka
AU - Hoshiyama, Yoshiharu
AU - Suzuki, Hiroshi
AU - Shimizu, Hiroyuki
AU - Toyoshima, Hideaki
AU - Tokudome, Shinkan
AU - Ito, Yoshinori
AU - Hashimoto, Shuji
AU - Kikuchi, Shogo
AU - Wakai, Kenji
AU - Koizumi, Akio
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Nose, Takayuki
AU - Hayakawa, Norihiko
AU - Yoshimura, Takesumi
AU - Okamoto, Naoyuki
AU - Shio, Hideo
AU - Kitagawa, Tomoyuki
AU - Kuroki, Toshio
AU - Tajima, Kazuo
PY - 2006
Y1 - 2006
N2 - The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95% confidence intervals (95%CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5% of men and 4.6% of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95%CI=1.47-3.59) and women (IRR=2.70; 95%CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95%CI=1.04-7.38) and stomach cancer (IRR=0.67; 95%CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95%CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.
AB - The study examined the association of diabetes mellitus (DM) history with total and common site-specific cancers using a large cohort of 23,378 men and 33,503 women, extracted from 127,477 healthy participants of the JACC Study who were aged 40-79 years and living in 24 municipalities in Japan. At enrolment during 1988-90, each subject completed a self-administered questionnaire including items for age, sex, body mass index (BMI), smoking, drinking, past history of DM and cancer. Adjusting for age, BMI, smoking, and drinking in the Cox's proportional hazard model, incidence rate ratios (IRR) with 95% confidence intervals (95%CIs) were estimated for both sexes. During the follow-up period, total cancers and site-specific cancers were identified. A history of DM was reported by 7.5% of men and 4.6% of women. DM significantly increased the risk of liver cancer for both men (IRR=2.30; 95%CI=1.47-3.59) and women (IRR=2.70; 95%CI=1.20-6.05). Significant increased and reduced risk due to DM for men were also found for non-Hodgkin lymphoma (IRR=2.77; 95%CI=1.04-7.38) and stomach cancer (IRR=0.67; 95%CI=0.46-0.99) respectively. For females, a reduced risk of stomach cancer due to DM (IRR=0.49; 95%CI=0.23-1.04) was also revealed. Since a history of DM here demonstrated significant associations with some site-specific cancers, their relationships should be studied further in Japan for validation.
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M3 - Article
C2 - 16839219
AN - SCOPUS:33748474259
SN - 1513-7368
VL - 7
SP - 253
EP - 259
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 2
ER -
