Six cases of acute hepatitis type B with arthritis as the initial symptom

Yoshihiho Fukuda; Hajime Takechi; Yukiharu Nakabou; Hiroyuki Kokuryu; Yuuji Sakai; Nozomu Hiraiwa; Kanji Hase; Yasuo Himeno; Shuuji Seko; Katsuji Kohigashi; Kengo Nagaoka; Masao Ueno; Hiroo Imura

doi:10.2957/kanzo.29.1502

Six cases of acute hepatitis type B with arthritis as the initial symptom

Yoshihiho Fukuda, Hajime Takechi, Yukiharu Nakabou, Hiroyuki Kokuryu, Yuuji Sakai, Nozomu Hiraiwa, Kanji Hase, Yasuo Himeno, Shuuji Seko, Katsuji Kohigashi, Kengo Nagaoka, Masao Ueno, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

Abstract

We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.

Original language	English
Pages (from-to)	1502-1508
Number of pages	7
Journal	Kanzo
Volume	29
Issue number	11
DOIs	https://doi.org/10.2957/kanzo.29.1502
Publication status	Published - 1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hepatology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2957/kanzo.29.1502

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title = "Six cases of acute hepatitis type B with arthritis as the initial symptom",

abstract = "We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.",

author = "Yoshihiho Fukuda and Hajime Takechi and Yukiharu Nakabou and Hiroyuki Kokuryu and Yuuji Sakai and Nozomu Hiraiwa and Kanji Hase and Yasuo Himeno and Shuuji Seko and Katsuji Kohigashi and Kengo Nagaoka and Masao Ueno and Hiroo Imura",

year = "1988",

doi = "10.2957/kanzo.29.1502",

language = "English",

volume = "29",

pages = "1502--1508",

journal = "Kanzo",

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publisher = "Japan Society of Hepatology",

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T1 - Six cases of acute hepatitis type B with arthritis as the initial symptom

AU - Fukuda, Yoshihiho

AU - Takechi, Hajime

AU - Nakabou, Yukiharu

AU - Kokuryu, Hiroyuki

AU - Sakai, Yuuji

AU - Hiraiwa, Nozomu

AU - Hase, Kanji

AU - Himeno, Yasuo

AU - Seko, Shuuji

AU - Kohigashi, Katsuji

AU - Nagaoka, Kengo

AU - Ueno, Masao

AU - Imura, Hiroo

PY - 1988

Y1 - 1988

N2 - We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.

AB - We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.

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DO - 10.2957/kanzo.29.1502

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EP - 1508

JO - Kanzo

JF - Kanzo

IS - 11

ER -

Six cases of acute hepatitis type B with arthritis as the initial symptom

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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