TY - JOUR
T1 - Six cases of acute hepatitis type B with arthritis as the initial symptom
AU - Fukuda, Yoshihiho
AU - Takechi, Hajime
AU - Nakabou, Yukiharu
AU - Kokuryu, Hiroyuki
AU - Sakai, Yuuji
AU - Hiraiwa, Nozomu
AU - Hase, Kanji
AU - Himeno, Yasuo
AU - Seko, Shuuji
AU - Kohigashi, Katsuji
AU - Nagaoka, Kengo
AU - Ueno, Masao
AU - Imura, Hiroo
PY - 1988
Y1 - 1988
N2 - We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.
AB - We present six patients with severe joint pain who were found to have hepatitis B virus (HBV) infection and the pathogenesis is discussed in this paper. The sera from five patients in the acute phase of their joint symptoms were obtained, so we determined the circulating immune complexes (IC) which had been thought to be the pathogenesis of arthritis. IC were detected in 2 out of 5 patients (40%) by using C1q solid phase enzyme immunoassay but were not detected in all patients by Raji cell enzyme immunoassay. Alternatively, HBs antigen · antibody IC by polyethleneglycol-trypsinization method were detected in 4 out 5 patients (80%). The levels of C3 and C4 were depressed in 2 (40%) and 3 patients (60%) respectively. These results suggest that circulating IC may not be related closely to arthritis occuring in prodrome of acute hepatitis type B. Therefore, it is also important to investigate the local deposition of IC or HBV replication in joints as one of the extrahepatic menifestations.
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U2 - 10.2957/kanzo.29.1502
DO - 10.2957/kanzo.29.1502
M3 - Article
AN - SCOPUS:0024253690
SN - 0451-4203
VL - 29
SP - 1502
EP - 1508
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
IS - 11
ER -