Size control of lipid-based drug carrier by drug loading

Tatsuya Murakami, Kunihiro Tsuchida, Mitsuru Hashida, Hiroshi Imahori

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A phospholipid-protein hybrid nanostructure was found to reveal various hydrodynamic diameters dependent on the amount of the drugs incorporated, which could be over 10 times larger than that of the starting nanostructure. This observation was likely related to the thermal stabilization of the nanostructure during incorporation of the drugs by using the increased amount of phospholipids for the preparation. Furthermore, hydrophobicity or molecular weight of drugs is at least needed for size control.

Original languageEnglish
Pages (from-to)789-791
Number of pages3
JournalMolecular BioSystems
Volume6
Issue number5
DOIs
Publication statusPublished - 21-05-2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology

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