Size control of lipid-based drug carrier by drug loading

Tatsuya Murakami, Kunihiro Tsuchida, Mitsuru Hashida, Hiroshi Imahori

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A phospholipid-protein hybrid nanostructure was found to reveal various hydrodynamic diameters dependent on the amount of the drugs incorporated, which could be over 10 times larger than that of the starting nanostructure. This observation was likely related to the thermal stabilization of the nanostructure during incorporation of the drugs by using the increased amount of phospholipids for the preparation. Furthermore, hydrophobicity or molecular weight of drugs is at least needed for size control.

Original languageEnglish
Pages (from-to)789-791
Number of pages3
JournalMolecular BioSystems
Volume6
Issue number5
DOIs
Publication statusPublished - 21-05-2010

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Drug Carriers
Nanostructures
Lipids
Phospholipids
Pharmaceutical Preparations
Hydrodynamics
Hydrophobic and Hydrophilic Interactions
Hot Temperature
Molecular Weight
Proteins

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology

Cite this

Murakami, Tatsuya ; Tsuchida, Kunihiro ; Hashida, Mitsuru ; Imahori, Hiroshi. / Size control of lipid-based drug carrier by drug loading. In: Molecular BioSystems. 2010 ; Vol. 6, No. 5. pp. 789-791.
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Size control of lipid-based drug carrier by drug loading. / Murakami, Tatsuya; Tsuchida, Kunihiro; Hashida, Mitsuru; Imahori, Hiroshi.

In: Molecular BioSystems, Vol. 6, No. 5, 21.05.2010, p. 789-791.

Research output: Contribution to journalArticle

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