Size, functional group effects and inhibition mode of graphene oxide for IMP-1 metallo-β-lactamase

Ayumu Kobayashi; Yoshihiro Yamaguchi; Sakura Maruki; Sunnam Kim; Yoshichika Arakawa; Seiji Kurihara

doi:10.1016/j.matlet.2022.131901

Size, functional group effects and inhibition mode of graphene oxide for IMP-1 metallo-β-lactamase

Ayumu Kobayashi, Yoshihiro Yamaguchi, Sakura Maruki, Sunnam Kim, Yoshichika Arakawa, Seiji Kurihara

Research output: Contribution to journal › Article › peer-review

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Abstract

Metallo-β-lactamase (MBL) is one of the zinc (II) enzymes that catalyzes hydrolysis of almost all the β-lactam antibiotics for clinical use. In this study, we have focused on enzyme inhibition by graphene oxides (GOs). We prepared GOs with different sizes, oxidation degrees and functional group positions, and investigated the enzyme inhibition for IMP-1 of MBL using four types of GOs: conventional GO, nano-sized GO (nGO), reduced GO (RGO), and reduced nGO (RnGO). It was demonstrated that reducing the size and oxidation degree of GOs can improve their inhibitory capacities and change their inhibition modes. The results of this study will lead to expand the range of applications of GOs and contribute to further development of MBL inhibitors in the future.

Original language	English
Article number	131901
Journal	Materials Letters
Volume	315
DOIs	https://doi.org/10.1016/j.matlet.2022.131901
Publication status	Published - 15-05-2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2022.131901

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title = "Size, functional group effects and inhibition mode of graphene oxide for IMP-1 metallo-β-lactamase",

abstract = "Metallo-β-lactamase (MBL) is one of the zinc (II) enzymes that catalyzes hydrolysis of almost all the β-lactam antibiotics for clinical use. In this study, we have focused on enzyme inhibition by graphene oxides (GOs). We prepared GOs with different sizes, oxidation degrees and functional group positions, and investigated the enzyme inhibition for IMP-1 of MBL using four types of GOs: conventional GO, nano-sized GO (nGO), reduced GO (RGO), and reduced nGO (RnGO). It was demonstrated that reducing the size and oxidation degree of GOs can improve their inhibitory capacities and change their inhibition modes. The results of this study will lead to expand the range of applications of GOs and contribute to further development of MBL inhibitors in the future.",

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T1 - Size, functional group effects and inhibition mode of graphene oxide for IMP-1 metallo-β-lactamase

AU - Kobayashi, Ayumu

AU - Yamaguchi, Yoshihiro

AU - Maruki, Sakura

AU - Kim, Sunnam

AU - Arakawa, Yoshichika

AU - Kurihara, Seiji

PY - 2022/5/15

Y1 - 2022/5/15

N2 - Metallo-β-lactamase (MBL) is one of the zinc (II) enzymes that catalyzes hydrolysis of almost all the β-lactam antibiotics for clinical use. In this study, we have focused on enzyme inhibition by graphene oxides (GOs). We prepared GOs with different sizes, oxidation degrees and functional group positions, and investigated the enzyme inhibition for IMP-1 of MBL using four types of GOs: conventional GO, nano-sized GO (nGO), reduced GO (RGO), and reduced nGO (RnGO). It was demonstrated that reducing the size and oxidation degree of GOs can improve their inhibitory capacities and change their inhibition modes. The results of this study will lead to expand the range of applications of GOs and contribute to further development of MBL inhibitors in the future.

AB - Metallo-β-lactamase (MBL) is one of the zinc (II) enzymes that catalyzes hydrolysis of almost all the β-lactam antibiotics for clinical use. In this study, we have focused on enzyme inhibition by graphene oxides (GOs). We prepared GOs with different sizes, oxidation degrees and functional group positions, and investigated the enzyme inhibition for IMP-1 of MBL using four types of GOs: conventional GO, nano-sized GO (nGO), reduced GO (RGO), and reduced nGO (RnGO). It was demonstrated that reducing the size and oxidation degree of GOs can improve their inhibitory capacities and change their inhibition modes. The results of this study will lead to expand the range of applications of GOs and contribute to further development of MBL inhibitors in the future.

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Size, functional group effects and inhibition mode of graphene oxide for IMP-1 metallo-β-lactamase

Abstract

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