SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system

Hiroyuki Kamei, Tsutomu Kameyama, Toshitaka Nabeshima

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10 Citations (Scopus)


Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. This stress-induced motor suppression was dose dependently attenuated by (±)-SKF-10,047, a σ receptor agonist, but not by its (-)-optical isomer ((-)-SKF-10,047) and the σ receptor ligands (+)-pentazocine and 1,3-di(2-tolyl)guanidine. This effect of (±)-SKf-10,047 was antagonized by BMY-14802, a σ receptor antagonist, and by pimozide, a dopamine receptor antagonist. When dopaminergic neurons were destroyed by pretreatment with 6-hydroxydopamine, the effect of (±)-SKF-10,047 on the stress response was also attenuated. Furthermore, (±)-SKF-10,047 dose dependently reversed the decrease in striatal dopamine turnover in the conditioned suppression group. These results suggest that stress-induced motor suppression is restored by (±)-SKF-10,047 acting through σ receptors, which are closely linked to the dopaminergic neuronal system.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - 21-07-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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