Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre-based Prospective Study

the Japan Public Health Centre-based Prospective Study Group

Research output: Contribution to journalArticle

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Abstract

Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes (MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40–69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated using a Cox regression model adjusted for potential confounders. Smoking was marginally associated with an increased risk of MDS among men, with a HR for current smokers relative to never smokers of 2·11 (95% CI: 0·91–4·89). In contrast, alcohol consumption was associated with a dose-dependent decrease in the risk of MDS among men (nondrinkers: reference, occasional drinkers: HR = 0·48, 0·16–1·41; 0–299 g/week: HR = 0·37, 0·19–0·73; ≥300 g/week: HR = 0·49, 0·22–1·08, P for trend = 0·010). This study showed that alcohol has a significant protective effect on the risk of MDS. In addition, this study might indicate that smoking increases the risk of MDS among Japanese population, as it does in Western populations.

Original languageEnglish
Pages (from-to)747-755
Number of pages9
JournalBritish Journal of Haematology
Volume178
Issue number5
DOIs
Publication statusPublished - 01-09-2017

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Myelodysplastic Syndromes
Japan
Public Health
Smoking
Alcohols
Prospective Studies
Alcohol Drinking
Confidence Intervals
Population
Proportional Hazards Models
Epidemiologic Studies
Cohort Studies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

@article{3bc323c13ed44101917e887b1662505a,
title = "Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan: the Japan Public Health Centre-based Prospective Study",
abstract = "Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes (MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40–69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up. Hazard ratios (HRs) and 95{\%} confidence intervals (95{\%} CI) were estimated using a Cox regression model adjusted for potential confounders. Smoking was marginally associated with an increased risk of MDS among men, with a HR for current smokers relative to never smokers of 2·11 (95{\%} CI: 0·91–4·89). In contrast, alcohol consumption was associated with a dose-dependent decrease in the risk of MDS among men (nondrinkers: reference, occasional drinkers: HR = 0·48, 0·16–1·41; 0–299 g/week: HR = 0·37, 0·19–0·73; ≥300 g/week: HR = 0·49, 0·22–1·08, P for trend = 0·010). This study showed that alcohol has a significant protective effect on the risk of MDS. In addition, this study might indicate that smoking increases the risk of MDS among Japanese population, as it does in Western populations.",
author = "{the Japan Public Health Centre-based Prospective Study Group} and Tomotaka Ugai and Keitaro Matsuo and Norie Sawada and Motoki Iwasaki and Taiki Yamaji and Taichi Shimazu and Shizuka Sasazuki and Manami Inoue and Yoshinobu Kanda and Shoichiro Tsugane and T. Hanaoka and J. Ogata and S. Baba and T. Mannami and A. Okayama and Y. Kokubo and K. Miyakawa and F. Saito and A. Koizumi and Y. Sano and I. Hashimoto and T. Ikuta and Y. Tanaba and H. Sato and Y. Roppongi and T. Takashima and H. Suzuki and Y. Miyajima and N. Suzuki and S. Nagasawa and Y. Furusugi and N. Nagai and Y. Ito and S. Komatsu and T. Minamizono and H. Sanada and Y. Hatayama and F. Kobayashi and H. Uchino and Y. Shirai and T. Kondo and R. Sasaki and Y. Watanabe and Y. Miyagawa and Y. Kobayashi and M. Machida and K. Kobayashi and M. Tsukada and Y. Kishimoto and Koji Suzuki",
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Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan : the Japan Public Health Centre-based Prospective Study. / the Japan Public Health Centre-based Prospective Study Group.

In: British Journal of Haematology, Vol. 178, No. 5, 01.09.2017, p. 747-755.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking and alcohol and subsequent risk of myelodysplastic syndromes in Japan

T2 - the Japan Public Health Centre-based Prospective Study

AU - the Japan Public Health Centre-based Prospective Study Group

AU - Ugai, Tomotaka

AU - Matsuo, Keitaro

AU - Sawada, Norie

AU - Iwasaki, Motoki

AU - Yamaji, Taiki

AU - Shimazu, Taichi

AU - Sasazuki, Shizuka

AU - Inoue, Manami

AU - Kanda, Yoshinobu

AU - Tsugane, Shoichiro

AU - Hanaoka, T.

AU - Ogata, J.

AU - Baba, S.

AU - Mannami, T.

AU - Okayama, A.

AU - Kokubo, Y.

AU - Miyakawa, K.

AU - Saito, F.

AU - Koizumi, A.

AU - Sano, Y.

AU - Hashimoto, I.

AU - Ikuta, T.

AU - Tanaba, Y.

AU - Sato, H.

AU - Roppongi, Y.

AU - Takashima, T.

AU - Suzuki, H.

AU - Miyajima, Y.

AU - Suzuki, N.

AU - Nagasawa, S.

AU - Furusugi, Y.

AU - Nagai, N.

AU - Ito, Y.

AU - Komatsu, S.

AU - Minamizono, T.

AU - Sanada, H.

AU - Hatayama, Y.

AU - Kobayashi, F.

AU - Uchino, H.

AU - Shirai, Y.

AU - Kondo, T.

AU - Sasaki, R.

AU - Watanabe, Y.

AU - Miyagawa, Y.

AU - Kobayashi, Y.

AU - Machida, M.

AU - Kobayashi, K.

AU - Tsukada, M.

AU - Kishimoto, Y.

AU - Suzuki, Koji

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes (MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40–69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated using a Cox regression model adjusted for potential confounders. Smoking was marginally associated with an increased risk of MDS among men, with a HR for current smokers relative to never smokers of 2·11 (95% CI: 0·91–4·89). In contrast, alcohol consumption was associated with a dose-dependent decrease in the risk of MDS among men (nondrinkers: reference, occasional drinkers: HR = 0·48, 0·16–1·41; 0–299 g/week: HR = 0·37, 0·19–0·73; ≥300 g/week: HR = 0·49, 0·22–1·08, P for trend = 0·010). This study showed that alcohol has a significant protective effect on the risk of MDS. In addition, this study might indicate that smoking increases the risk of MDS among Japanese population, as it does in Western populations.

AB - Smoking and alcohol are important modifiable risk factors for human cancers. However, few epidemiological studies have investigated their association with the risk of myelodysplastic syndromes (MDS). Here, we investigated the association of smoking and alcohol consumption and the risk of MDS in a large-scale population-based cohort study in Japan. We included 95 510 Japanese subjects (45 451 men and 50 059 women; age 40–69 years at baseline) and identified 70 MDS cases (50 men and 20 women) during 18·3 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated using a Cox regression model adjusted for potential confounders. Smoking was marginally associated with an increased risk of MDS among men, with a HR for current smokers relative to never smokers of 2·11 (95% CI: 0·91–4·89). In contrast, alcohol consumption was associated with a dose-dependent decrease in the risk of MDS among men (nondrinkers: reference, occasional drinkers: HR = 0·48, 0·16–1·41; 0–299 g/week: HR = 0·37, 0·19–0·73; ≥300 g/week: HR = 0·49, 0·22–1·08, P for trend = 0·010). This study showed that alcohol has a significant protective effect on the risk of MDS. In addition, this study might indicate that smoking increases the risk of MDS among Japanese population, as it does in Western populations.

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DO - 10.1111/bjh.14749

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JF - British Journal of Haematology

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