Smoking and serum CA19-9 levels according to Lewis and secretor genotypes

Sayo Kawai, Koji Suzuki, Kazuko Nishio, Yoshiko Ishida, Rieko Okada, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Yoshinori Ito, Nobuyuki Hamajima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

CA19-9, a marker for cancers of biliary tract, pancreas and colorectum, is not synthesized in those with no enzyme activity genotype (le/le) of Lewis (Le) gene. No enzyme activity genotype (se/se) of secretor (Se) gene is known to have an association with high serum CA19-9 levels. There are also variations in serum CA19-9 levels independent of the genotypes. This study aimed to examine the associations of serum CA19-9 levels with smoking, alcohol drinking and body mass index (BMI; kg/m2), after the adjustments of Le and Se genotypes. Subjects were 486 health check-up examinees (158 males and 328 females) aged from 39 to 90 years in Hokkaido, Japan. Genotyping was conducted for 3 polymorphisms; Le T59G (59T for Le allele and 59G for le allele), Se A385T (385A for Se allele and 385T for sej allele), and Se pseudogene (se5 allele). The genotypes of Le and Se were deterministic factors of serum CA19-9. Those with Le/Le & se/se had the highest mean, while CA19-9 was not detected or very low in those with le/le. Although no associations were observed with alcohol drinking and BMI, a significant association was observed with smoking. Among those with Le/Le, the geometric mean of CA19-9 was significantly lower for current smokers than for noncurrent smokers (p = 0.011 in 4-way ANOVA with age, sex and Se genotype). When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9.

Original languageEnglish
Pages (from-to)2880-2884
Number of pages5
JournalInternational Journal of Cancer
Volume123
Issue number12
DOIs
Publication statusPublished - 15-12-2008

Fingerprint

Smoking
Genotype
Alleles
Serum
Alcohol Drinking
Biliary Tract Neoplasms
Social Adjustment
Pseudogenes
Enzymes
Smoke
Tobacco Products
Genes
Pancreas
Analysis of Variance
Japan
Hemoglobins
Body Mass Index
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kawai, S., Suzuki, K., Nishio, K., Ishida, Y., Okada, R., Goto, Y., ... Hamajima, N. (2008). Smoking and serum CA19-9 levels according to Lewis and secretor genotypes. International Journal of Cancer, 123(12), 2880-2884. https://doi.org/10.1002/ijc.23907
Kawai, Sayo ; Suzuki, Koji ; Nishio, Kazuko ; Ishida, Yoshiko ; Okada, Rieko ; Goto, Yasuyuki ; Naito, Mariko ; Wakai, Kenji ; Ito, Yoshinori ; Hamajima, Nobuyuki. / Smoking and serum CA19-9 levels according to Lewis and secretor genotypes. In: International Journal of Cancer. 2008 ; Vol. 123, No. 12. pp. 2880-2884.
@article{935cdeceb29b4a73b3ff5e9d9c280416,
title = "Smoking and serum CA19-9 levels according to Lewis and secretor genotypes",
abstract = "CA19-9, a marker for cancers of biliary tract, pancreas and colorectum, is not synthesized in those with no enzyme activity genotype (le/le) of Lewis (Le) gene. No enzyme activity genotype (se/se) of secretor (Se) gene is known to have an association with high serum CA19-9 levels. There are also variations in serum CA19-9 levels independent of the genotypes. This study aimed to examine the associations of serum CA19-9 levels with smoking, alcohol drinking and body mass index (BMI; kg/m2), after the adjustments of Le and Se genotypes. Subjects were 486 health check-up examinees (158 males and 328 females) aged from 39 to 90 years in Hokkaido, Japan. Genotyping was conducted for 3 polymorphisms; Le T59G (59T for Le allele and 59G for le allele), Se A385T (385A for Se allele and 385T for sej allele), and Se pseudogene (se5 allele). The genotypes of Le and Se were deterministic factors of serum CA19-9. Those with Le/Le & se/se had the highest mean, while CA19-9 was not detected or very low in those with le/le. Although no associations were observed with alcohol drinking and BMI, a significant association was observed with smoking. Among those with Le/Le, the geometric mean of CA19-9 was significantly lower for current smokers than for noncurrent smokers (p = 0.011 in 4-way ANOVA with age, sex and Se genotype). When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9.",
author = "Sayo Kawai and Koji Suzuki and Kazuko Nishio and Yoshiko Ishida and Rieko Okada and Yasuyuki Goto and Mariko Naito and Kenji Wakai and Yoshinori Ito and Nobuyuki Hamajima",
year = "2008",
month = "12",
day = "15",
doi = "10.1002/ijc.23907",
language = "English",
volume = "123",
pages = "2880--2884",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",

}

Kawai, S, Suzuki, K, Nishio, K, Ishida, Y, Okada, R, Goto, Y, Naito, M, Wakai, K, Ito, Y & Hamajima, N 2008, 'Smoking and serum CA19-9 levels according to Lewis and secretor genotypes', International Journal of Cancer, vol. 123, no. 12, pp. 2880-2884. https://doi.org/10.1002/ijc.23907

Smoking and serum CA19-9 levels according to Lewis and secretor genotypes. / Kawai, Sayo; Suzuki, Koji; Nishio, Kazuko; Ishida, Yoshiko; Okada, Rieko; Goto, Yasuyuki; Naito, Mariko; Wakai, Kenji; Ito, Yoshinori; Hamajima, Nobuyuki.

In: International Journal of Cancer, Vol. 123, No. 12, 15.12.2008, p. 2880-2884.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking and serum CA19-9 levels according to Lewis and secretor genotypes

AU - Kawai, Sayo

AU - Suzuki, Koji

AU - Nishio, Kazuko

AU - Ishida, Yoshiko

AU - Okada, Rieko

AU - Goto, Yasuyuki

AU - Naito, Mariko

AU - Wakai, Kenji

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

PY - 2008/12/15

Y1 - 2008/12/15

N2 - CA19-9, a marker for cancers of biliary tract, pancreas and colorectum, is not synthesized in those with no enzyme activity genotype (le/le) of Lewis (Le) gene. No enzyme activity genotype (se/se) of secretor (Se) gene is known to have an association with high serum CA19-9 levels. There are also variations in serum CA19-9 levels independent of the genotypes. This study aimed to examine the associations of serum CA19-9 levels with smoking, alcohol drinking and body mass index (BMI; kg/m2), after the adjustments of Le and Se genotypes. Subjects were 486 health check-up examinees (158 males and 328 females) aged from 39 to 90 years in Hokkaido, Japan. Genotyping was conducted for 3 polymorphisms; Le T59G (59T for Le allele and 59G for le allele), Se A385T (385A for Se allele and 385T for sej allele), and Se pseudogene (se5 allele). The genotypes of Le and Se were deterministic factors of serum CA19-9. Those with Le/Le & se/se had the highest mean, while CA19-9 was not detected or very low in those with le/le. Although no associations were observed with alcohol drinking and BMI, a significant association was observed with smoking. Among those with Le/Le, the geometric mean of CA19-9 was significantly lower for current smokers than for noncurrent smokers (p = 0.011 in 4-way ANOVA with age, sex and Se genotype). When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9.

AB - CA19-9, a marker for cancers of biliary tract, pancreas and colorectum, is not synthesized in those with no enzyme activity genotype (le/le) of Lewis (Le) gene. No enzyme activity genotype (se/se) of secretor (Se) gene is known to have an association with high serum CA19-9 levels. There are also variations in serum CA19-9 levels independent of the genotypes. This study aimed to examine the associations of serum CA19-9 levels with smoking, alcohol drinking and body mass index (BMI; kg/m2), after the adjustments of Le and Se genotypes. Subjects were 486 health check-up examinees (158 males and 328 females) aged from 39 to 90 years in Hokkaido, Japan. Genotyping was conducted for 3 polymorphisms; Le T59G (59T for Le allele and 59G for le allele), Se A385T (385A for Se allele and 385T for sej allele), and Se pseudogene (se5 allele). The genotypes of Le and Se were deterministic factors of serum CA19-9. Those with Le/Le & se/se had the highest mean, while CA19-9 was not detected or very low in those with le/le. Although no associations were observed with alcohol drinking and BMI, a significant association was observed with smoking. Among those with Le/Le, the geometric mean of CA19-9 was significantly lower for current smokers than for noncurrent smokers (p = 0.011 in 4-way ANOVA with age, sex and Se genotype). When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9.

UR - http://www.scopus.com/inward/record.url?scp=57349159445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57349159445&partnerID=8YFLogxK

U2 - 10.1002/ijc.23907

DO - 10.1002/ijc.23907

M3 - Article

C2 - 18803289

AN - SCOPUS:57349159445

VL - 123

SP - 2880

EP - 2884

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 12

ER -