TY - JOUR
T1 - Smoking cessation and COPD mortality among Japanese men and women
T2 - The JACC study
AU - Li, Yuanying
AU - Yamagishi, Kazumasa
AU - Yatsuya, Hiroshi
AU - Tamakoshi, Akiko
AU - Iso, Hiroyasu
N1 - Funding Information:
The JACC Study has been supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan ( 61010076 , 62010074 , 63010074 , 1010068 , 2151065 , 3151064 , 4151063 , 5151069 , 6279102 , and 11181101 ).
PY - 2012/12
Y1 - 2012/12
N2 - Objective: To investigate an effect of smoking cessation on chronic obstructive pulmonary disease (COPD) mortality in Asians. Methods: The data was obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 41465 Japanese men and 52662 Japanese women aged 40-79. years who had no history of COPD, asthma, other chronic lung diseases, cardiovascular disease or cancer were followed between 1988 and 2008. Results: During median 18-year of follow-up, there were 285 (251 men and 34 women) documented deaths from COPD. Multivariable-adjusted hazard ratios with 95% confidence intervals of COPD death were 4.46 (2.72-7.29) and 9.26 (4.19-20.5), respectively for current male and female smokers when compared to never smokers. Compared with current smokers, the multivariable HRs for 5-9. years and 10. years or more smoking cessation prior to baseline were 0.44 (0.22-0.87) and 0.36 (0.22-0.58) in men, respectively while the HR for never smokers was 0.30 (0.16-0.57). There were an insufficient number of COPD deaths in women to clarify this association. Conclusion: Smoking cessation for ten years or more prior to enrollment reverses the excess risk of COPD mortality to a level similar to that observed among never smokers in men.
AB - Objective: To investigate an effect of smoking cessation on chronic obstructive pulmonary disease (COPD) mortality in Asians. Methods: The data was obtained from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). A total of 41465 Japanese men and 52662 Japanese women aged 40-79. years who had no history of COPD, asthma, other chronic lung diseases, cardiovascular disease or cancer were followed between 1988 and 2008. Results: During median 18-year of follow-up, there were 285 (251 men and 34 women) documented deaths from COPD. Multivariable-adjusted hazard ratios with 95% confidence intervals of COPD death were 4.46 (2.72-7.29) and 9.26 (4.19-20.5), respectively for current male and female smokers when compared to never smokers. Compared with current smokers, the multivariable HRs for 5-9. years and 10. years or more smoking cessation prior to baseline were 0.44 (0.22-0.87) and 0.36 (0.22-0.58) in men, respectively while the HR for never smokers was 0.30 (0.16-0.57). There were an insufficient number of COPD deaths in women to clarify this association. Conclusion: Smoking cessation for ten years or more prior to enrollment reverses the excess risk of COPD mortality to a level similar to that observed among never smokers in men.
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U2 - 10.1016/j.ypmed.2012.09.006
DO - 10.1016/j.ypmed.2012.09.006
M3 - Article
C2 - 22982769
AN - SCOPUS:84872424086
SN - 0091-7435
VL - 55
SP - 639
EP - 643
JO - Preventive Medicine
JF - Preventive Medicine
IS - 6
ER -
