TY - JOUR
T1 - Smoking increases the treatment failure for Helicobacter pylori eradication
AU - Suzuki, Takeshi
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Sawaki, Akira
AU - Hirose, Kaoru
AU - Wakai, Kenji
AU - Sato, Shigeki
AU - Nakamura, Tsuneya
AU - Yamao, Kenji
AU - Ueda, Ryuzo
AU - Tajima, Kazuo
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Cancer Research (17-1) from the Ministry of Health, Labour and Welfare, Tokyo, Japan.
PY - 2006/3
Y1 - 2006/3
N2 - PURPOSE: Treatment failure for Helicobacter pylori (H. pylori) eradication is encountered in approximately 10-20% of patients, and many studies have pointed to a link with smoking. To investigate the effects of smoking on eradication outcome, we performed a meta-analysis. METHODS: A PubMed search was performed to retrieve articles published up to August 2005. Pooled odds ratio (OR) and differences rate for H. pylori eradication failure in smokers compared with nonsmokers were used as summary statistics. Meta-regression was used for examining the source of heterogeneity. RESULTS: Twenty-two published studies (5538 patients), which provided information on eradication failure according to smoking status, were included in the analysis. The summary OR for eradication failure among smokers relative to nonsmokers was 1.95 (95% confidence interval [CI]: 1.55-2.45; P <.01). It corresponds with the differences in eradication rates between smokers and nonsmokers (8.4% [95% CI: 3.3-13.5%, P <.01]). Meta-regression analysis demonstrated that a high proportion of nonulcer dyspepsia patients in studies revealed a higher failure rate among smokers, compared with a low proportion of nonulcer dyspepsia. CONCLUSIONS: Our meta-analysis demonstrated that smoking increases the treatment failure rate for H. pylori eradication.
AB - PURPOSE: Treatment failure for Helicobacter pylori (H. pylori) eradication is encountered in approximately 10-20% of patients, and many studies have pointed to a link with smoking. To investigate the effects of smoking on eradication outcome, we performed a meta-analysis. METHODS: A PubMed search was performed to retrieve articles published up to August 2005. Pooled odds ratio (OR) and differences rate for H. pylori eradication failure in smokers compared with nonsmokers were used as summary statistics. Meta-regression was used for examining the source of heterogeneity. RESULTS: Twenty-two published studies (5538 patients), which provided information on eradication failure according to smoking status, were included in the analysis. The summary OR for eradication failure among smokers relative to nonsmokers was 1.95 (95% confidence interval [CI]: 1.55-2.45; P <.01). It corresponds with the differences in eradication rates between smokers and nonsmokers (8.4% [95% CI: 3.3-13.5%, P <.01]). Meta-regression analysis demonstrated that a high proportion of nonulcer dyspepsia patients in studies revealed a higher failure rate among smokers, compared with a low proportion of nonulcer dyspepsia. CONCLUSIONS: Our meta-analysis demonstrated that smoking increases the treatment failure rate for H. pylori eradication.
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U2 - 10.1016/j.amjmed.2005.10.003
DO - 10.1016/j.amjmed.2005.10.003
M3 - Review article
C2 - 16490464
AN - SCOPUS:32844461824
SN - 0002-9343
VL - 119
SP - 217
EP - 224
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 3
ER -