Smoking results in accumulation of ectopic fat in the liver

Ayako Kato, Yuanying Li, Atsuhiko Ota, Hisao Naito, Hiroya Yamada, Takashi Nihashi, Yo Hotta, Chifa Chiang, Yoshihisa Hirakawa, Atsuko Aoyama, Koji Tamakoshi, Hiroshi Yatsuya

Research output: Contribution to journalArticle

Abstract

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume12
DOIs
Publication statusPublished - 01-01-2019

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Smoking
Fats
Adiponectin
Liver
Triglycerides
Magnetic Resonance Spectroscopy
Alcohols
Exercise
Adipocytes
Fasting
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Pharmacology

Cite this

Kato, Ayako ; Li, Yuanying ; Ota, Atsuhiko ; Naito, Hisao ; Yamada, Hiroya ; Nihashi, Takashi ; Hotta, Yo ; Chiang, Chifa ; Hirakawa, Yoshihisa ; Aoyama, Atsuko ; Tamakoshi, Koji ; Yatsuya, Hiroshi. / Smoking results in accumulation of ectopic fat in the liver. In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019 ; Vol. 12. pp. 1075-1080.
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abstract = "Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.",
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Kato, A, Li, Y, Ota, A, Naito, H, Yamada, H, Nihashi, T, Hotta, Y, Chiang, C, Hirakawa, Y, Aoyama, A, Tamakoshi, K & Yatsuya, H 2019, 'Smoking results in accumulation of ectopic fat in the liver', Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 12, pp. 1075-1080. https://doi.org/10.2147/DMSO.S212495

Smoking results in accumulation of ectopic fat in the liver. / Kato, Ayako; Li, Yuanying; Ota, Atsuhiko; Naito, Hisao; Yamada, Hiroya; Nihashi, Takashi; Hotta, Yo; Chiang, Chifa; Hirakawa, Yoshihisa; Aoyama, Atsuko; Tamakoshi, Koji; Yatsuya, Hiroshi.

In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. 12, 01.01.2019, p. 1075-1080.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking results in accumulation of ectopic fat in the liver

AU - Kato, Ayako

AU - Li, Yuanying

AU - Ota, Atsuhiko

AU - Naito, Hisao

AU - Yamada, Hiroya

AU - Nihashi, Takashi

AU - Hotta, Yo

AU - Chiang, Chifa

AU - Hirakawa, Yoshihisa

AU - Aoyama, Atsuko

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

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