SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

Asako Aoki; Kouichi Ozaki; Hiroshi Sato; Atsushi Takahashi; Michiaki Kubo; Yasuhiko Sakata; Yoshihiro Onouchi; Takahisa Kawaguchi; Tsung Hsien Lin; Hitoshi Takano; Masahiro Yasutake; Po Chao Hsu; Shiro Ikegawa; Naoyuki Kamatani; Tatsuhiko Tsunoda; Suh Hang H. Juo; Masatsugu Hori; Issei Komuro; Kyoichi Mizuno; Yusuke Nakamura; Toshihiro Tanaka

doi:10.1038/jhg.2010.141

SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

Asako Aoki, Kouichi Ozaki, Hiroshi Sato, Atsushi Takahashi, Michiaki Kubo, Yasuhiko Sakata, Yoshihiro Onouchi, Takahisa Kawaguchi, Tsung Hsien Lin, Hitoshi Takano, Masahiro Yasutake, Po Chao Hsu, Shiro Ikegawa, Naoyuki Kamatani, Tatsuhiko Tsunoda, Suh Hang H. Juo, Masatsugu Hori, Issei Komuro, Kyoichi Mizuno, Yusuke NakamuraToshihiro Tanaka

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 ^-13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Journal of Human Genetics
Volume	56
Issue number	1
DOIs	https://doi.org/10.1038/jhg.2010.141
Publication status	Published - 01-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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Aoki, A., Ozaki, K., Sato, H., Takahashi, A., Kubo, M., Sakata, Y., Onouchi, Y., Kawaguchi, T., Lin, T. H., Takano, H., Yasutake, M., Hsu, P. C., Ikegawa, S., Kamatani, N., Tsunoda, T., Juo, S. H. H., Hori, M., Komuro, I., Mizuno, K., ... Tanaka, T. (2011). SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. Journal of Human Genetics, 56(1), 47-51. https://doi.org/10.1038/jhg.2010.141

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title = "SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population",

abstract = "Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.",

author = "Asako Aoki and Kouichi Ozaki and Hiroshi Sato and Atsushi Takahashi and Michiaki Kubo and Yasuhiko Sakata and Yoshihiro Onouchi and Takahisa Kawaguchi and Lin, {Tsung Hsien} and Hitoshi Takano and Masahiro Yasutake and Hsu, {Po Chao} and Shiro Ikegawa and Naoyuki Kamatani and Tatsuhiko Tsunoda and Juo, {Suh Hang H.} and Masatsugu Hori and Issei Komuro and Kyoichi Mizuno and Yusuke Nakamura and Toshihiro Tanaka",

year = "2011",

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doi = "10.1038/jhg.2010.141",

language = "English",

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Aoki, A, Ozaki, K, Sato, H, Takahashi, A, Kubo, M, Sakata, Y, Onouchi, Y, Kawaguchi, T, Lin, TH, Takano, H, Yasutake, M, Hsu, PC, Ikegawa, S, Kamatani, N, Tsunoda, T, Juo, SHH, Hori, M, Komuro, I, Mizuno, K, Nakamura, Y & Tanaka, T 2011, 'SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population', Journal of Human Genetics, vol. 56, no. 1, pp. 47-51. https://doi.org/10.1038/jhg.2010.141

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T1 - SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

AU - Aoki, Asako

AU - Ozaki, Kouichi

AU - Sato, Hiroshi

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Sakata, Yasuhiko

AU - Onouchi, Yoshihiro

AU - Kawaguchi, Takahisa

AU - Lin, Tsung Hsien

AU - Takano, Hitoshi

AU - Yasutake, Masahiro

AU - Hsu, Po Chao

AU - Ikegawa, Shiro

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Juo, Suh Hang H.

AU - Hori, Masatsugu

AU - Komuro, Issei

AU - Mizuno, Kyoichi

AU - Nakamura, Yusuke

AU - Tanaka, Toshihiro

PY - 2011/1

Y1 - 2011/1

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AB - Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

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JO - Journal of Human Genetics

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SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

Abstract

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