SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

Asako Aoki, Kouichi Ozaki, Hiroshi Sato, Atsushi Takahashi, Michiaki Kubo, Yasuhiko Sakata, Yoshihiro Onouchi, Takahisa Kawaguchi, Tsung Hsien Lin, Hitoshi Takano, Masahiro Yasutake, Po Chao Hsu, Shiro Ikegawa, Naoyuki Kamatani, Tatsuhiko Tsunoda, Suh Hang H. Juo, Masatsugu Hori, Issei Komuro, Kyoichi Mizuno, Yusuke NakamuraToshihiro Tanaka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalJournal of Human Genetics
Volume56
Issue number1
DOIs
Publication statusPublished - 01-01-2011

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Single Nucleotide Polymorphism
Chromosomes
Myocardial Infarction
Population
Genome-Wide Association Study
Linkage Disequilibrium
Gene Frequency
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Aoki, Asako ; Ozaki, Kouichi ; Sato, Hiroshi ; Takahashi, Atsushi ; Kubo, Michiaki ; Sakata, Yasuhiko ; Onouchi, Yoshihiro ; Kawaguchi, Takahisa ; Lin, Tsung Hsien ; Takano, Hitoshi ; Yasutake, Masahiro ; Hsu, Po Chao ; Ikegawa, Shiro ; Kamatani, Naoyuki ; Tsunoda, Tatsuhiko ; Juo, Suh Hang H. ; Hori, Masatsugu ; Komuro, Issei ; Mizuno, Kyoichi ; Nakamura, Yusuke ; Tanaka, Toshihiro. / SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. In: Journal of Human Genetics. 2011 ; Vol. 56, No. 1. pp. 47-51.
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Aoki, A, Ozaki, K, Sato, H, Takahashi, A, Kubo, M, Sakata, Y, Onouchi, Y, Kawaguchi, T, Lin, TH, Takano, H, Yasutake, M, Hsu, PC, Ikegawa, S, Kamatani, N, Tsunoda, T, Juo, SHH, Hori, M, Komuro, I, Mizuno, K, Nakamura, Y & Tanaka, T 2011, 'SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population', Journal of Human Genetics, vol. 56, no. 1, pp. 47-51. https://doi.org/10.1038/jhg.2010.141

SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. / Aoki, Asako; Ozaki, Kouichi; Sato, Hiroshi; Takahashi, Atsushi; Kubo, Michiaki; Sakata, Yasuhiko; Onouchi, Yoshihiro; Kawaguchi, Takahisa; Lin, Tsung Hsien; Takano, Hitoshi; Yasutake, Masahiro; Hsu, Po Chao; Ikegawa, Shiro; Kamatani, Naoyuki; Tsunoda, Tatsuhiko; Juo, Suh Hang H.; Hori, Masatsugu; Komuro, Issei; Mizuno, Kyoichi; Nakamura, Yusuke; Tanaka, Toshihiro.

In: Journal of Human Genetics, Vol. 56, No. 1, 01.01.2011, p. 47-51.

Research output: Contribution to journalArticle

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T1 - SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

AU - Aoki, Asako

AU - Ozaki, Kouichi

AU - Sato, Hiroshi

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Sakata, Yasuhiko

AU - Onouchi, Yoshihiro

AU - Kawaguchi, Takahisa

AU - Lin, Tsung Hsien

AU - Takano, Hitoshi

AU - Yasutake, Masahiro

AU - Hsu, Po Chao

AU - Ikegawa, Shiro

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Juo, Suh Hang H.

AU - Hori, Masatsugu

AU - Komuro, Issei

AU - Mizuno, Kyoichi

AU - Nakamura, Yusuke

AU - Tanaka, Toshihiro

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

AB - Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

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