SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

Asako Aoki, Kouichi Ozaki, Hiroshi Sato, Atsushi Takahashi, Michiaki Kubo, Yasuhiko Sakata, Yoshihiro Onouchi, Takahisa Kawaguchi, Tsung Hsien Lin, Hitoshi Takano, Masahiro Yasutake, Po Chao Hsu, Shiro Ikegawa, Naoyuki Kamatani, Tatsuhiko Tsunoda, Suh Hang H. Juo, Masatsugu Hori, Issei Komuro, Kyoichi Mizuno, Yusuke NakamuraToshihiro Tanaka

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Abstract

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10 -13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalJournal of Human Genetics
Volume56
Issue number1
DOIs
Publication statusPublished - 01-01-2011

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Aoki, A., Ozaki, K., Sato, H., Takahashi, A., Kubo, M., Sakata, Y., Onouchi, Y., Kawaguchi, T., Lin, T. H., Takano, H., Yasutake, M., Hsu, P. C., Ikegawa, S., Kamatani, N., Tsunoda, T., Juo, S. H. H., Hori, M., Komuro, I., Mizuno, K., ... Tanaka, T. (2011). SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. Journal of Human Genetics, 56(1), 47-51. https://doi.org/10.1038/jhg.2010.141