Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi, Katsuki Tsuritani, Yusuke Kuwahara, Hiroyuki Kamei, Taku Nagai, Yukio Yoneda, Toshitaka Nabeshima, Kiyofumi Yamada

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Experiences during brain development may influence the pathogenesis of developmental disorders. Thus, social isolation (SI) rearing after weaning is a useful animal model for studying the pathological mechanisms of such psychiatric diseases. In this study, we examined the effect of SI on neurogenesis in the hippocampal dentate gyrus (DG) relating to memory and emotion-related behaviors. When newly divided cells were labeled with 5-bromo-2′-deoxyuridine (BrdU) before SI, the number of BrdU-positive cells and the rate of differentiation into neurons were significantly decreased after 4-week SI compared with those in group-housed mice. Repeated treatment of fluoxetine prevented the SI-induced impairment of survival of newly divided cells and ameliorated spatial memory impairment and part of aggression in SI mice. Furthermore, we investigated the changes in gene expression in the DG of SI mice by using DNA microarray and real-time PCR. We finally found that SI reduced the expression of development-related genes Nurr1 and Npas4. These findings suggest that communication in juvenile is important in the survival and differentiation of newly divided cells, which may be associated with memory and aggression, and raise the possibility that the reduced expression of Nurr1 and/or Npas4 may contribute to the impairment of neurogenesis and memory and aggression induced by SI.

Original languageEnglish
Pages (from-to)921-932
Number of pages12
JournalJournal of Neurochemistry
Volume105
Issue number3
DOIs
Publication statusPublished - 01-05-2008
Externally publishedYes

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Social Isolation
Neurogenesis
Emotions
Data storage equipment
Bromodeoxyuridine
Aggression
Fluoxetine
Microarrays
Dentate Gyrus
Gene expression
Neurons
Brain
Animals
Genes
Cells
Spatial Memory
DNA
Communication
Parahippocampal Gyrus
Weaning

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Ibi, Daisuke ; Takuma, Kazuhiro ; Koike, Hiroyuki ; Mizoguchi, Hiroyuki ; Tsuritani, Katsuki ; Kuwahara, Yusuke ; Kamei, Hiroyuki ; Nagai, Taku ; Yoneda, Yukio ; Nabeshima, Toshitaka ; Yamada, Kiyofumi. / Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. In: Journal of Neurochemistry. 2008 ; Vol. 105, No. 3. pp. 921-932.
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Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. / Ibi, Daisuke; Takuma, Kazuhiro; Koike, Hiroyuki; Mizoguchi, Hiroyuki; Tsuritani, Katsuki; Kuwahara, Yusuke; Kamei, Hiroyuki; Nagai, Taku; Yoneda, Yukio; Nabeshima, Toshitaka; Yamada, Kiyofumi.

In: Journal of Neurochemistry, Vol. 105, No. 3, 01.05.2008, p. 921-932.

Research output: Contribution to journalArticle

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AU - Ibi, Daisuke

AU - Takuma, Kazuhiro

AU - Koike, Hiroyuki

AU - Mizoguchi, Hiroyuki

AU - Tsuritani, Katsuki

AU - Kuwahara, Yusuke

AU - Kamei, Hiroyuki

AU - Nagai, Taku

AU - Yoneda, Yukio

AU - Nabeshima, Toshitaka

AU - Yamada, Kiyofumi

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