Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse

Gen Kawa, Shizuko Nagao, Akitsugu Yamamoto, Koichiro Omori, Yosuke Komatz, Hisahide Takahashi, Yutaka Tashiro

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recently, it has been reported that Na,K-ATPase in the renal epithelia of human autosomal dominant polycystic kidney disease and cpk mouse, a murine model of autosomal recessive polycystic kidney disease, mislocates to apical plasma membrane and that mislocated Na,K-ATPase causes the cyst formation. Whether the DBA/2FG-pcy mice, which are presumably a suitable model for autosomal dominant polycystic kidney disease, also exhibit the reversal polarity of Na,K-ATPase localization was examined. Kidneys of newborn DBA/2FG-PCY mice, and those at early and late stages of cyst development were examined by immunohistochemical techniques. At any stage, abnormal distribution of Na,K-ATPase on the apical membranes of tubular epithelial cells could not be detected. It is suggested that cysts can be formed without reversed polarity of Na,K-ATPase distribution in pcy mice.

Original languageEnglish
Pages (from-to)2040-2049
Number of pages10
JournalJournal of the American Society of Nephrology
Volume4
Issue number12
Publication statusPublished - 01-06-1994

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Sodium-Potassium-Exchanging ATPase
Polycystic Kidney Diseases
Autosomal Dominant Polycystic Kidney
Cysts
Autosomal Recessive Polycystic Kidney
Kidney
Epithelium
Epithelial Cells
Cell Membrane
sodium-translocating ATPase
Membranes

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kawa, G., Nagao, S., Yamamoto, A., Omori, K., Komatz, Y., Takahashi, H., & Tashiro, Y. (1994). Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse. Journal of the American Society of Nephrology, 4(12), 2040-2049.
Kawa, Gen ; Nagao, Shizuko ; Yamamoto, Akitsugu ; Omori, Koichiro ; Komatz, Yosuke ; Takahashi, Hisahide ; Tashiro, Yutaka. / Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse. In: Journal of the American Society of Nephrology. 1994 ; Vol. 4, No. 12. pp. 2040-2049.
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Kawa, G, Nagao, S, Yamamoto, A, Omori, K, Komatz, Y, Takahashi, H & Tashiro, Y 1994, 'Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse', Journal of the American Society of Nephrology, vol. 4, no. 12, pp. 2040-2049.

Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse. / Kawa, Gen; Nagao, Shizuko; Yamamoto, Akitsugu; Omori, Koichiro; Komatz, Yosuke; Takahashi, Hisahide; Tashiro, Yutaka.

In: Journal of the American Society of Nephrology, Vol. 4, No. 12, 01.06.1994, p. 2040-2049.

Research output: Contribution to journalArticle

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