Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse

Gen Kawa, Shizuko Nagao, Akitsugu Yamamoto, Koichiro Omori, Yosuke Komatz, Hisahide Takahashi, Yutaka Tashiro

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Recently, it has been reported that Na,K-ATPase in the renal epithelia of human autosomal dominant polycystic kidney disease and cpk mouse, a murine model of autosomal recessive polycystic kidney disease, mislocates to apical plasma membrane and that mislocated Na,K-ATPase causes the cyst formation. Whether the DBA/2FG-pcy mice, which are presumably a suitable model for autosomal dominant polycystic kidney disease, also exhibit the reversal polarity of Na,K-ATPase localization was examined. Kidneys of newborn DBA/2FG-PCY mice, and those at early and late stages of cyst development were examined by immunohistochemical techniques. At any stage, abnormal distribution of Na,K-ATPase on the apical membranes of tubular epithelial cells could not be detected. It is suggested that cysts can be formed without reversed polarity of Na,K-ATPase distribution in pcy mice.

Original languageEnglish
Pages (from-to)2040-2049
Number of pages10
JournalJournal of the American Society of Nephrology
Volume4
Issue number12
Publication statusPublished - 06-1994

All Science Journal Classification (ASJC) codes

  • Nephrology

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