Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Shota Kurotsu; Taketaro Sadahiro; Ryo Fujita; Hidenori Tani; Hiroyuki Yamakawa; Fumiya Tamura; Mari Isomi; Hidenori Kojima; Yu Yamada; Yuto Abe; Yoshiko Murakata; Tatsuya Akiyama; Naoto Muraoka; Ichiro Harada; Takeshi Suzuki; Keiichi Fukuda; Masaki Ieda

doi:10.1016/j.stemcr.2020.07.022

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Shota Kurotsu
, Taketaro Sadahiro
, Ryo Fujita
, Hidenori Tani
, Hiroyuki Yamakawa
, Fumiya Tamura
, Mari Isomi
, Hidenori Kojima
, Yu Yamada
, Yuto Abe
, Yoshiko Murakata
, Tatsuya Akiyama
, Naoto Muraoka
, Ichiro Harada
, Takeshi Suzuki
, Keiichi Fukuda
, Masaki Ieda

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.

Original language	English
Pages (from-to)	612-628
Number of pages	17
Journal	Stem Cell Reports
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2020.07.022
Publication status	Published - 08-09-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Genetics
Developmental Biology
Cell Biology

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10.1016/j.stemcr.2020.07.022

Cite this

Kurotsu, S., Sadahiro, T., Fujita, R., Tani, H., Yamakawa, H., Tamura, F., Isomi, M., Kojima, H., Yamada, Y., Abe, Y., Murakata, Y., Akiyama, T., Muraoka, N., Harada, I., Suzuki, T., Fukuda, K., & Ieda, M. (2020). Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures. Stem Cell Reports, 15(3), 612-628. https://doi.org/10.1016/j.stemcr.2020.07.022

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title = "Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures",

abstract = "In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.",

keywords = "cardiac reprogramming, mechanotransduction, myocardium, soft matrix, YAP/TAZ",

author = "Shota Kurotsu and Taketaro Sadahiro and Ryo Fujita and Hidenori Tani and Hiroyuki Yamakawa and Fumiya Tamura and Mari Isomi and Hidenori Kojima and Yu Yamada and Yuto Abe and Yoshiko Murakata and Tatsuya Akiyama and Naoto Muraoka and Ichiro Harada and Takeshi Suzuki and Keiichi Fukuda and Masaki Ieda",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = sep,

day = "8",

doi = "10.1016/j.stemcr.2020.07.022",

language = "English",

volume = "15",

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journal = "Stem Cell Reports",

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Kurotsu, S, Sadahiro, T, Fujita, R, Tani, H, Yamakawa, H, Tamura, F, Isomi, M, Kojima, H, Yamada, Y, Abe, Y, Murakata, Y, Akiyama, T, Muraoka, N, Harada, I, Suzuki, T, Fukuda, K & Ieda, M 2020, 'Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures', Stem Cell Reports, vol. 15, no. 3, pp. 612-628. https://doi.org/10.1016/j.stemcr.2020.07.022

TY - JOUR

T1 - Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

AU - Kurotsu, Shota

AU - Sadahiro, Taketaro

AU - Fujita, Ryo

AU - Tani, Hidenori

AU - Yamakawa, Hiroyuki

AU - Tamura, Fumiya

AU - Isomi, Mari

AU - Kojima, Hidenori

AU - Yamada, Yu

AU - Abe, Yuto

AU - Murakata, Yoshiko

AU - Akiyama, Tatsuya

AU - Muraoka, Naoto

AU - Harada, Ichiro

AU - Suzuki, Takeshi

AU - Fukuda, Keiichi

AU - Ieda, Masaki

PY - 2020/9/8

Y1 - 2020/9/8

N2 - In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.

AB - In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.

KW - cardiac reprogramming

KW - mechanotransduction

KW - myocardium

KW - soft matrix

KW - YAP/TAZ

UR - https://www.scopus.com/pages/publications/85090146441

UR - https://www.scopus.com/pages/publications/85090146441#tab=citedBy

U2 - 10.1016/j.stemcr.2020.07.022

DO - 10.1016/j.stemcr.2020.07.022

M3 - Article

C2 - 32857980

AN - SCOPUS:85090146441

SN - 2213-6711

VL - 15

SP - 612

EP - 628

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Abstract

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