Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma

Vinod Kumar, Paulisally Hau Yi Lo, Hiromi Sawai, Naoya Kato, Atsushi Takahashi, Zhenzhong Deng, Yuji Urabe, Hamdi Mbarek, Katsushi Tokunaga, Yasuhito Tanaka, Masaya Sugiyama, Masashi Mizokami, Ryosuke Muroyama, Ryosuke Tateishi, Masao Omata, Kazuhiko Koike, Chizu Tanikawa, Naoyuki Kamatani, Michiaki Kubo, Yusuke NakamuraKoichi Matsuda

Research output: Contribution to journalArticle

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Abstract

MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.

Original languageEnglish
Article numbere44743
JournalPloS one
Volume7
Issue number9
DOIs
Publication statusPublished - 14-09-2012

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Hepatitis B virus
Biomarkers
hepatoma
Viruses
Hepatocellular Carcinoma
biomarkers
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
Virus Diseases
Serum
Alleles
Association reactions
alleles
Hepatitis C virus
Genetic Promoter Regions
Hepacivirus
infection
Liver

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kumar, V., Yi Lo, P. H., Sawai, H., Kato, N., Takahashi, A., Deng, Z., ... Matsuda, K. (2012). Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma. PloS one, 7(9), [e44743]. https://doi.org/10.1371/journal.pone.0044743
Kumar, Vinod ; Yi Lo, Paulisally Hau ; Sawai, Hiromi ; Kato, Naoya ; Takahashi, Atsushi ; Deng, Zhenzhong ; Urabe, Yuji ; Mbarek, Hamdi ; Tokunaga, Katsushi ; Tanaka, Yasuhito ; Sugiyama, Masaya ; Mizokami, Masashi ; Muroyama, Ryosuke ; Tateishi, Ryosuke ; Omata, Masao ; Koike, Kazuhiko ; Tanikawa, Chizu ; Kamatani, Naoyuki ; Kubo, Michiaki ; Nakamura, Yusuke ; Matsuda, Koichi. / Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma. In: PloS one. 2012 ; Vol. 7, No. 9.
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Kumar, V, Yi Lo, PH, Sawai, H, Kato, N, Takahashi, A, Deng, Z, Urabe, Y, Mbarek, H, Tokunaga, K, Tanaka, Y, Sugiyama, M, Mizokami, M, Muroyama, R, Tateishi, R, Omata, M, Koike, K, Tanikawa, C, Kamatani, N, Kubo, M, Nakamura, Y & Matsuda, K 2012, 'Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma', PloS one, vol. 7, no. 9, e44743. https://doi.org/10.1371/journal.pone.0044743

Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma. / Kumar, Vinod; Yi Lo, Paulisally Hau; Sawai, Hiromi; Kato, Naoya; Takahashi, Atsushi; Deng, Zhenzhong; Urabe, Yuji; Mbarek, Hamdi; Tokunaga, Katsushi; Tanaka, Yasuhito; Sugiyama, Masaya; Mizokami, Masashi; Muroyama, Ryosuke; Tateishi, Ryosuke; Omata, Masao; Koike, Kazuhiko; Tanikawa, Chizu; Kamatani, Naoyuki; Kubo, Michiaki; Nakamura, Yusuke; Matsuda, Koichi.

In: PloS one, Vol. 7, No. 9, e44743, 14.09.2012.

Research output: Contribution to journalArticle

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T1 - Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma

AU - Kumar, Vinod

AU - Yi Lo, Paulisally Hau

AU - Sawai, Hiromi

AU - Kato, Naoya

AU - Takahashi, Atsushi

AU - Deng, Zhenzhong

AU - Urabe, Yuji

AU - Mbarek, Hamdi

AU - Tokunaga, Katsushi

AU - Tanaka, Yasuhito

AU - Sugiyama, Masaya

AU - Mizokami, Masashi

AU - Muroyama, Ryosuke

AU - Tateishi, Ryosuke

AU - Omata, Masao

AU - Koike, Kazuhiko

AU - Tanikawa, Chizu

AU - Kamatani, Naoyuki

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Matsuda, Koichi

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Y1 - 2012/9/14

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