Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers

Kosaku Uchida, Masaaki Nagatake, Hirotaka Osada, Yasushi Yatabe, Masashi Kondo, Tetsuva Mitsudomi, Akira Masuda, Toshitada Takahashi, Takashi Takahashi

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135 Citations (Scopus)

Abstract

The chromosome region 18q21 is frequently deleted in lung cancers. Recent identification of JV18-1 at this locus led us to examine whether or not it might also be altered in long cancers, as is the case for the closely related DPC4 tumor suppressor gene. A missense somatic mutation and a 9-bp in-frame deletion were detected in the highly conserved region of JV18-1 among 57 lung cancer specimens taken directly from patients. The total alterations in JV18-1 and DPC4, however, are not sufficient to account for all 18q21 deletions in lung cancers. These findings suggest that although JV18-1 and DPC4 may play roles in a limited fraction of lung cancers, another tumor suppressor gene may also exist in this chromosome region.

Original languageEnglish
Pages (from-to)5583-5585
Number of pages3
JournalCancer Research
Volume56
Issue number24
Publication statusPublished - 15-12-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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