Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers

Kosaku Uchida, Masaaki Nagatake, Hirotaka Osada, Yasushi Yatabe, Masashi Kondo, Tetsuva Mitsudomi, Akira Masuda, Toshitada Takahashi, Takashi Takahashi

Research output: Contribution to journalArticle

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Abstract

The chromosome region 18q21 is frequently deleted in lung cancers. Recent identification of JV18-1 at this locus led us to examine whether or not it might also be altered in long cancers, as is the case for the closely related DPC4 tumor suppressor gene. A missense somatic mutation and a 9-bp in-frame deletion were detected in the highly conserved region of JV18-1 among 57 lung cancer specimens taken directly from patients. The total alterations in JV18-1 and DPC4, however, are not sufficient to account for all 18q21 deletions in lung cancers. These findings suggest that although JV18-1 and DPC4 may play roles in a limited fraction of lung cancers, another tumor suppressor gene may also exist in this chromosome region.

Original languageEnglish
Pages (from-to)5583-5585
Number of pages3
JournalCancer Research
Volume56
Issue number24
Publication statusPublished - 15-12-1996

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Lung Neoplasms
Tumor Suppressor Genes
Genes
Chromosomes
Missense Mutation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Uchida, K., Nagatake, M., Osada, H., Yatabe, Y., Kondo, M., Mitsudomi, T., ... Takahashi, T. (1996). Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Research, 56(24), 5583-5585.
Uchida, Kosaku ; Nagatake, Masaaki ; Osada, Hirotaka ; Yatabe, Yasushi ; Kondo, Masashi ; Mitsudomi, Tetsuva ; Masuda, Akira ; Takahashi, Toshitada ; Takahashi, Takashi. / Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. In: Cancer Research. 1996 ; Vol. 56, No. 24. pp. 5583-5585.
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Uchida, K, Nagatake, M, Osada, H, Yatabe, Y, Kondo, M, Mitsudomi, T, Masuda, A, Takahashi, T & Takahashi, T 1996, 'Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers', Cancer Research, vol. 56, no. 24, pp. 5583-5585.

Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. / Uchida, Kosaku; Nagatake, Masaaki; Osada, Hirotaka; Yatabe, Yasushi; Kondo, Masashi; Mitsudomi, Tetsuva; Masuda, Akira; Takahashi, Toshitada; Takahashi, Takashi.

In: Cancer Research, Vol. 56, No. 24, 15.12.1996, p. 5583-5585.

Research output: Contribution to journalArticle

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AU - Nagatake, Masaaki

AU - Osada, Hirotaka

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AU - Kondo, Masashi

AU - Mitsudomi, Tetsuva

AU - Masuda, Akira

AU - Takahashi, Toshitada

AU - Takahashi, Takashi

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AB - The chromosome region 18q21 is frequently deleted in lung cancers. Recent identification of JV18-1 at this locus led us to examine whether or not it might also be altered in long cancers, as is the case for the closely related DPC4 tumor suppressor gene. A missense somatic mutation and a 9-bp in-frame deletion were detected in the highly conserved region of JV18-1 among 57 lung cancer specimens taken directly from patients. The total alterations in JV18-1 and DPC4, however, are not sufficient to account for all 18q21 deletions in lung cancers. These findings suggest that although JV18-1 and DPC4 may play roles in a limited fraction of lung cancers, another tumor suppressor gene may also exist in this chromosome region.

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Uchida K, Nagatake M, Osada H, Yatabe Y, Kondo M, Mitsudomi T et al. Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Research. 1996 Dec 15;56(24):5583-5585.