TY - JOUR
T1 - Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease
AU - Hritcu, Lucian
AU - Ciobica, Alin
AU - Stefan, Marius
AU - Mihasan, Marius
AU - Palamiuc, Lavinia
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This work was supported by CNCSIS–UEFISCSU , Impact of bacterial superantigens on the animal organism physiological status project number 1073/2009, PNII–IDEI code 85/2008, Romania.
PY - 2011/9
Y1 - 2011/9
N2 - Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.
AB - Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.
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U2 - 10.1016/j.neures.2011.05.016
DO - 10.1016/j.neures.2011.05.016
M3 - Article
C2 - 21663772
AN - SCOPUS:79960925337
SN - 0168-0102
VL - 71
SP - 35
EP - 43
JO - Neuroscience Research
JF - Neuroscience Research
IS - 1
ER -