Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

Lucian Hritcu, Alin Ciobica, Marius Stefan, Marius Mihasan, Lavinia Palamiuc, Toshitaka Nabeshima

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalNeuroscience Research
Volume71
Issue number1
DOIs
Publication statusPublished - 01-09-2011
Externally publishedYes

Fingerprint

Oxidopamine
Memory Disorders
Parkinson Disease
Lipopolysaccharides
Rodentia
Oxidative Stress
Immune System
Substantia Nigra
Spatial Memory
Wistar Rats
Control Groups
Injections
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hritcu, Lucian ; Ciobica, Alin ; Stefan, Marius ; Mihasan, Marius ; Palamiuc, Lavinia ; Nabeshima, Toshitaka. / Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease. In: Neuroscience Research. 2011 ; Vol. 71, No. 1. pp. 35-43.
@article{6e92a6f1291940a78a6eb41670975fc0,
title = "Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease",
abstract = "Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.",
author = "Lucian Hritcu and Alin Ciobica and Marius Stefan and Marius Mihasan and Lavinia Palamiuc and Toshitaka Nabeshima",
year = "2011",
month = "9",
day = "1",
doi = "10.1016/j.neures.2011.05.016",
language = "English",
volume = "71",
pages = "35--43",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease. / Hritcu, Lucian; Ciobica, Alin; Stefan, Marius; Mihasan, Marius; Palamiuc, Lavinia; Nabeshima, Toshitaka.

In: Neuroscience Research, Vol. 71, No. 1, 01.09.2011, p. 35-43.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

AU - Hritcu, Lucian

AU - Ciobica, Alin

AU - Stefan, Marius

AU - Mihasan, Marius

AU - Palamiuc, Lavinia

AU - Nabeshima, Toshitaka

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.

AB - Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2μg/μl saline; 5μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.

UR - http://www.scopus.com/inward/record.url?scp=79960925337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960925337&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2011.05.016

DO - 10.1016/j.neures.2011.05.016

M3 - Article

VL - 71

SP - 35

EP - 43

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 1

ER -