Species and cell types difference in tryptophan metabolism

Yuki Murakami, Kuniaki Saito

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

L-Tryptophan (L-TRP) is a nutritionally essential amino acid and the kynurenine (KYN) pathway is the major route of L-TRP catabolism. Besides being synthesized for proteins, L-TRP and its metabolites have critical roles for the functions of nervous and immune systems. Many researches show that optimal amounts of L-TRP in diets depend on species, developmental stages, environmental factors and health status. We have shown that KYN pathway-related enzyme activities vary among species, tissue and cell types in physiological conditions. Furthermore, the response of these enzyme activities to systemic and/or central nervous system immune activation and inflammation depends on species and cell types. Thus, it is very important to choose appropriate animal species and cell types in which to evaluate the physiologic and pathologic effects of increased KYN pathway metabolism. We believe that understanding L-TRP metabolism among species and cell types provides a better idea for analysis of human pathological condition.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalInternational Journal of Tryptophan Research
Volume6
Issue numberSUPPL.1
DOIs
Publication statusPublished - 27-08-2013
Externally publishedYes

Fingerprint

Metabolism
Tryptophan
Kynurenine
Enzyme activity
Neurology
Essential Amino Acids
Environmental Health
Immune system
Enzymes
Nutrition
Metabolites
Nervous System
Health Status
Immune System
Animals
Central Nervous System
Chemical activation
Health
Tissue
Diet

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

@article{4253b298e3c545068d0e99bad916513f,
title = "Species and cell types difference in tryptophan metabolism",
abstract = "L-Tryptophan (L-TRP) is a nutritionally essential amino acid and the kynurenine (KYN) pathway is the major route of L-TRP catabolism. Besides being synthesized for proteins, L-TRP and its metabolites have critical roles for the functions of nervous and immune systems. Many researches show that optimal amounts of L-TRP in diets depend on species, developmental stages, environmental factors and health status. We have shown that KYN pathway-related enzyme activities vary among species, tissue and cell types in physiological conditions. Furthermore, the response of these enzyme activities to systemic and/or central nervous system immune activation and inflammation depends on species and cell types. Thus, it is very important to choose appropriate animal species and cell types in which to evaluate the physiologic and pathologic effects of increased KYN pathway metabolism. We believe that understanding L-TRP metabolism among species and cell types provides a better idea for analysis of human pathological condition.",
author = "Yuki Murakami and Kuniaki Saito",
year = "2013",
month = "8",
day = "27",
doi = "10.4137/IJTR.S11558",
language = "English",
volume = "6",
pages = "47--54",
journal = "International Journal of Tryptophan Research",
issn = "1178-6469",
publisher = "Libertas Academica Ltd.",
number = "SUPPL.1",

}

Species and cell types difference in tryptophan metabolism. / Murakami, Yuki; Saito, Kuniaki.

In: International Journal of Tryptophan Research, Vol. 6, No. SUPPL.1, 27.08.2013, p. 47-54.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Species and cell types difference in tryptophan metabolism

AU - Murakami, Yuki

AU - Saito, Kuniaki

PY - 2013/8/27

Y1 - 2013/8/27

N2 - L-Tryptophan (L-TRP) is a nutritionally essential amino acid and the kynurenine (KYN) pathway is the major route of L-TRP catabolism. Besides being synthesized for proteins, L-TRP and its metabolites have critical roles for the functions of nervous and immune systems. Many researches show that optimal amounts of L-TRP in diets depend on species, developmental stages, environmental factors and health status. We have shown that KYN pathway-related enzyme activities vary among species, tissue and cell types in physiological conditions. Furthermore, the response of these enzyme activities to systemic and/or central nervous system immune activation and inflammation depends on species and cell types. Thus, it is very important to choose appropriate animal species and cell types in which to evaluate the physiologic and pathologic effects of increased KYN pathway metabolism. We believe that understanding L-TRP metabolism among species and cell types provides a better idea for analysis of human pathological condition.

AB - L-Tryptophan (L-TRP) is a nutritionally essential amino acid and the kynurenine (KYN) pathway is the major route of L-TRP catabolism. Besides being synthesized for proteins, L-TRP and its metabolites have critical roles for the functions of nervous and immune systems. Many researches show that optimal amounts of L-TRP in diets depend on species, developmental stages, environmental factors and health status. We have shown that KYN pathway-related enzyme activities vary among species, tissue and cell types in physiological conditions. Furthermore, the response of these enzyme activities to systemic and/or central nervous system immune activation and inflammation depends on species and cell types. Thus, it is very important to choose appropriate animal species and cell types in which to evaluate the physiologic and pathologic effects of increased KYN pathway metabolism. We believe that understanding L-TRP metabolism among species and cell types provides a better idea for analysis of human pathological condition.

UR - http://www.scopus.com/inward/record.url?scp=84882633181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882633181&partnerID=8YFLogxK

U2 - 10.4137/IJTR.S11558

DO - 10.4137/IJTR.S11558

M3 - Review article

VL - 6

SP - 47

EP - 54

JO - International Journal of Tryptophan Research

JF - International Journal of Tryptophan Research

SN - 1178-6469

IS - SUPPL.1

ER -