Specific cell-mediated immunity in fish

T. Nakanishi; K. Aoyagi; C. Xia; J. M. Dijkstra; M. Ototake

doi:10.1016/S0165-2427(99)00122-1

Specific cell-mediated immunity in fish

T. Nakanishi, K. Aoyagi, C. Xia, J. M. Dijkstra, M. Ototake

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

This review describes the fish immune system, focusing on specific cell- mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.

Original language	English
Pages (from-to)	101-109
Number of pages	9
Journal	Veterinary Immunology and Immunopathology
Volume	72
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-2427(99)00122-1
Publication status	Published - 15-12-1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology
General Veterinary

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10.1016/S0165-2427(99)00122-1

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AU - Nakanishi, T.

AU - Aoyagi, K.

AU - Xia, C.

AU - Dijkstra, J. M.

AU - Ototake, M.

PY - 1999/12/15

Y1 - 1999/12/15

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AB - This review describes the fish immune system, focusing on specific cell- mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.

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JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 1-2

ER -

Specific cell-mediated immunity in fish

Abstract

All Science Journal Classification (ASJC) codes

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