TY - JOUR
T1 - Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects
AU - Kaniwa, Nahoko
AU - Sugiyama, Emiko
AU - Saito, Yoshiro
AU - Kurose, Kouichi
AU - Maekawa, Keiko
AU - Hasegawa, Ryuichi
AU - Furuya, Hirokazu
AU - Ikeda, Hiroko
AU - Takahashi, Yukitoshi
AU - Muramatsu, Masaaki
AU - Tohkin, Masahiro
AU - Ozeki, Takeshi
AU - Mushiroda, Taisei
AU - Kubo, Michiaki
AU - Kamatani, Naoyuki
AU - Abe, Masamichi
AU - Yagami, Akiko
AU - Ueta, Mayumi
AU - Sotozono, Chie
AU - Kinoshita, Shigeru
AU - Ikezawa, Zenro
AU - Matsunaga, Kayoko
AU - Aihara, Michiko
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - This preliminary study investigated genomic biomarkers for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide, phenobarbital and phenytoin. Patients & methods: HLA class I and HLA-DRB1 loci were genotyped for Japanese patients with zonisamide-, phenobarbital- or phenytoin-induced SJS/TEN (n = 12, 8 and 9, respectively) and for healthy Japanese volunteers (n = 2878). Results: Carrier frequencies of HLA-A*02:07 in patients with zonisamide-induced SJS/TEN and in the general Japanese population were 41.7 and 6.81%, respectively. Carrier frequencies of HLA-B*51:01 in patients with phenobarbital- and phenytoin-induced SJS/TEN and in controls were 75.0, 55.6 and 15.2%, respectively. HLA-A*02:07 and HLA-B*51:01, in a dominant model, were significantly associated with zonisamide- and phenobarbital-induced SJS/TEN, respectively (Pc = 0.0176 and 0.0042, respectively). Conclusion: Our data suggest that HLA-A*02:07 and HLA-B*51:01 are potential biomarkers for zonisamide- and phenobarbital-induced SJS/TEN, respectively, in Japanese individuals.
AB - This preliminary study investigated genomic biomarkers for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide, phenobarbital and phenytoin. Patients & methods: HLA class I and HLA-DRB1 loci were genotyped for Japanese patients with zonisamide-, phenobarbital- or phenytoin-induced SJS/TEN (n = 12, 8 and 9, respectively) and for healthy Japanese volunteers (n = 2878). Results: Carrier frequencies of HLA-A*02:07 in patients with zonisamide-induced SJS/TEN and in the general Japanese population were 41.7 and 6.81%, respectively. Carrier frequencies of HLA-B*51:01 in patients with phenobarbital- and phenytoin-induced SJS/TEN and in controls were 75.0, 55.6 and 15.2%, respectively. HLA-A*02:07 and HLA-B*51:01, in a dominant model, were significantly associated with zonisamide- and phenobarbital-induced SJS/TEN, respectively (Pc = 0.0176 and 0.0042, respectively). Conclusion: Our data suggest that HLA-A*02:07 and HLA-B*51:01 are potential biomarkers for zonisamide- and phenobarbital-induced SJS/TEN, respectively, in Japanese individuals.
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U2 - 10.2217/PGS.13.180
DO - 10.2217/PGS.13.180
M3 - Article
C2 - 24236482
AN - SCOPUS:84893344987
VL - 14
SP - 1821
EP - 1831
JO - Pharmacogenomics
JF - Pharmacogenomics
SN - 1462-2416
IS - 15
ER -